PMID- 37169822
OWN - NLM
STAT- MEDLINE
DCOM- 20230714
LR  - 20230718
IS  - 1759-5037 (Electronic)
IS  - 1759-5029 (Linking)
VI  - 19
IP  - 8
DP  - 2023 Aug
TI  - Prioritization of genes associated with type 2 diabetes mellitus for functional 
      studies.
PG  - 477-486
LID - 10.1038/s41574-023-00836-1 [doi]
AB  - Existing therapies for type 2 diabetes mellitus (T2DM) show limited efficacy or 
      have adverse effects. Numerous genetic variants associated with T2DM have been 
      identified, but progress in translating these findings into potential drug 
      targets has been limited. Here, we describe the tools and platforms available to 
      identify effector genes from T2DM-associated coding and non-coding variants and 
      prioritize them for functional studies. We discuss QSER1 and SLC12A8 as examples 
      of genes that have been identified as possible T2DM candidate genes using these 
      tools and platforms. We suggest further approaches, including the use of 
      sequencing data with increased sample size and ethnic diversity, single-cell 
      omics data for analyses, glycaemic trait associations to predict gene function 
      and, potentially, human induced pluripotent stem cell 'village' cultures, to 
      strengthen current gene functionalization workflows. Effective prioritization of 
      T2DM-associated genes for experimental validation could expedite our 
      understanding of the genetic mechanisms responsible for T2DM to facilitate the 
      use of precision medicine in its treatment.
CI  - (c) 2023. Springer Nature Limited.
FAU - Tan, Wei Xuan
AU  - Tan WX
AD  - Stem Cells and Diabetes Laboratory, Institute of Molecular and Cell Biology 
      (IMCB), Agency for Science, Technology and Research (A*STAR), Singapore, 
      Singapore.
AD  - Department of Medicine, Yong Loo Lin School of Medicine, National University of 
      Singapore, Singapore, Singapore.
FAU - Sim, Xueling
AU  - Sim X
AD  - Saw Swee Hock School of Public Health, National University of Singapore and 
      National University Health System, Singapore, Singapore.
FAU - Khoo, Chin Meng
AU  - Khoo CM
AD  - Department of Medicine, Yong Loo Lin School of Medicine, National University of 
      Singapore, Singapore, Singapore.
FAU - Teo, Adrian K K
AU  - Teo AKK
AUID- ORCID: 0000-0001-5901-7075
AD  - Stem Cells and Diabetes Laboratory, Institute of Molecular and Cell Biology 
      (IMCB), Agency for Science, Technology and Research (A*STAR), Singapore, 
      Singapore. ateo@imcb.a-star.edu.sg.
AD  - Department of Medicine, Yong Loo Lin School of Medicine, National University of 
      Singapore, Singapore, Singapore. ateo@imcb.a-star.edu.sg.
AD  - Precision Medicine Translational Research Programme, Yong Loo Lin School of 
      Medicine, National University of Singapore, Singapore, Singapore. 
      ateo@imcb.a-star.edu.sg.
AD  - Department of Biochemistry, Yong Loo Lin School of Medicine, National University 
      of Singapore, Singapore, Singapore. ateo@imcb.a-star.edu.sg.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20230511
PL  - England
TA  - Nat Rev Endocrinol
JT  - Nature reviews. Endocrinology
JID - 101500078
SB  - IM
MH  - Humans
MH  - *Diabetes Mellitus, Type 2/genetics
MH  - *Induced Pluripotent Stem Cells
MH  - Phenotype
EDAT- 2023/05/12 01:07
MHDA- 2023/07/14 13:08
CRDT- 2023/05/11 23:19
PHST- 2023/03/28 00:00 [accepted]
PHST- 2023/07/14 13:08 [medline]
PHST- 2023/05/12 01:07 [pubmed]
PHST- 2023/05/11 23:19 [entrez]
AID - 10.1038/s41574-023-00836-1 [pii]
AID - 10.1038/s41574-023-00836-1 [doi]
PST - ppublish
SO  - Nat Rev Endocrinol. 2023 Aug;19(8):477-486. doi: 10.1038/s41574-023-00836-1. Epub 
      2023 May 11.