PMID- 37172120
OWN - NLM
STAT- MEDLINE
DCOM- 20230821
LR  - 20231003
IS  - 1600-065X (Electronic)
IS  - 0105-2896 (Print)
IS  - 0105-2896 (Linking)
VI  - 317
IP  - 1
DP  - 2023 Aug
TI  - Lipid metabolism in dendritic cell biology.
PG  - 137-151
LID - 10.1111/imr.13215 [doi]
AB  - Dendritic cells (DCs) are innate immune cells that detect and process 
      environmental signals and communicate them with T cells to bridge innate and 
      adaptive immunity. Immune signals and microenvironmental cues shape the function 
      of DC subsets in different contexts, which is associated with reprogramming of 
      cellular metabolic pathways. In addition to integrating these extracellular cues 
      to meet bioenergetic and biosynthetic demands, cellular metabolism interplays 
      with immune signaling to shape DC-dependent immune responses. Emerging evidence 
      indicates that lipid metabolism serves as a key regulator of DC responses. Here, 
      we summarize the roles of fatty acid and cholesterol metabolism, as well as 
      selective metabolites, in orchestrating the functions of DCs. Specifically, we 
      highlight how different lipid metabolic programs, including de novo fatty acid 
      synthesis, fatty acid beta oxidation, lipid storage, and cholesterol efflux, 
      influence DC function in different contexts. Further, we discuss how 
      dysregulation of lipid metabolism shapes DC intracellular signaling and 
      contributes to the impaired DC function in the tumor microenvironment. Finally, 
      we conclude with a discussion on key future directions for the regulation of DC 
      biology by lipid metabolism. Insights into the connections between lipid 
      metabolism and DC functional specialization may facilitate the development of new 
      therapeutic strategies for human diseases.
CI  - (c) 2023 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.
FAU - You, Zhiyuan
AU  - You Z
AUID- ORCID: 0000-0001-9833-7485
AD  - Department of Immunology, St. Jude Children's Research Hospital, Memphis, 
      Tennessee, USA.
FAU - Chi, Hongbo
AU  - Chi H
AUID- ORCID: 0000-0002-9997-2496
AD  - Department of Immunology, St. Jude Children's Research Hospital, Memphis, 
      Tennessee, USA.
LA  - eng
GR  - R01 AI131703/AI/NIAID NIH HHS/United States
GR  - R01 AI150514/AI/NIAID NIH HHS/United States
GR  - R37 AI105887/AI/NIAID NIH HHS/United States
GR  - R35 CA253188/CA/NCI NIH HHS/United States
GR  - R01 AI150241/AI/NIAID NIH HHS/United States
GR  - R01 AI140761/AI/NIAID NIH HHS/United States
GR  - R01 AI105887/AI/NIAID NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20230512
PL  - England
TA  - Immunol Rev
JT  - Immunological reviews
JID - 7702118
RN  - 0 (Fatty Acids)
RN  - 97C5T2UQ7J (Cholesterol)
SB  - IM
MH  - Humans
MH  - *Lipid Metabolism
MH  - *Dendritic Cells
MH  - Fatty Acids/metabolism
MH  - Cholesterol/metabolism
MH  - Biology
PMC - PMC10523915
MID - NIHMS1896611
OTO - NOTNLM
OT  - cholesterol
OT  - dendritic cells
OT  - fatty acid
OT  - innate immunity
OT  - lipid metabolism
OT  - lipid metabolites
EDAT- 2023/05/12 19:07
MHDA- 2023/08/21 06:42
PMCR- 2024/08/01
CRDT- 2023/05/12 14:22
PHST- 2024/08/01 00:00 [pmc-release]
PHST- 2023/08/21 06:42 [medline]
PHST- 2023/05/12 19:07 [pubmed]
PHST- 2023/05/12 14:22 [entrez]
AID - 10.1111/imr.13215 [doi]
PST - ppublish
SO  - Immunol Rev. 2023 Aug;317(1):137-151. doi: 10.1111/imr.13215. Epub 2023 May 12.