PMID- 37172619 OWN - NLM STAT- MEDLINE DCOM- 20230707 LR - 20240423 IS - 1872-9738 (Electronic) IS - 0892-0362 (Print) IS - 0892-0362 (Linking) VI - 98 DP - 2023 Jul-Aug TI - Associations of prenatal exposure to per- and polyfluoroalkyl substances (PFAS) with measures of cognition in 7.5-month-old infants: An exploratory study. PG - 107182 LID - S0892-0362(23)00032-6 [pii] LID - 10.1016/j.ntt.2023.107182 [doi] AB - BACKGROUND: Prenatal exposure to per- and polyfluoroalkyl substances (PFAS) has been linked to a wide array of adverse maternal and child health outcomes. However, studies examining PFAS in relation to offspring cognition have been inconclusive. OBJECTIVE: We examined whether prenatal exposure to a mixture of PFAS was related to cognition in 7.5-month-old infants. METHODS: Our analytic sample included participants enrolled in the Chemicals in Our Bodies (CIOB) and Illinois Kids Development Study (IKIDS) cohorts (N = 163). Seven PFAS were measured in 2nd trimester maternal serum samples and were detected in >65% of participants. Infant cognition was measured with a visual recognition memory task using an infrared eye tracker when infants were 7.5 months old. This task included familiarization trials where each infant was shown two identical faces and test trials where each infant was shown the familiar face paired with a novel face. In familiarization, we assessed average run duration (time looking at familiarization stimuli before looking away) as a measure of information processing speed, in addition to time to familiarization (time to reach 20 s of looking at stimuli) and shift rate (the number of times infants looked between stimuli), both as measures of attention. In test trials, we assessed novelty preference (proportion of time looking to the novel face) to measure recognition memory. Linear regression was used to estimate associations of individual PFAS with cognitive outcomes, while Bayesian kernel machine regression (BKMR) was used to estimate mixture effects. RESULTS: In adjusted single-PFAS linear regression models, an interquartile range increase in PFNA, PFOA, PFOS, PFHxS, PFDeA, and PFUdA was associated with an increase in shift rate, reflecting better visual attention. Using BKMR, increasing quartiles of the PFAS mixture was similarly associated with a modest increase in shift rate. There were no significant associations between PFAS exposure and time to reach familiarization (another measure of attention), average run duration (information processing speed), or novelty preference (visual recognition memory). CONCLUSION: In our study population, prenatal PFAS exposure was modestly associated with an increase in shift rate and was not strongly associated with any adverse cognitive outcomes in 7.5-month-old infants. CI - Copyright (c) 2023 Elsevier Inc. All rights reserved. FAU - Enright, Elizabeth A AU - Enright EA AD - Department of Psychology, St. Mary's College of Maryland, St. Mary's City, MD, USA. Electronic address: eaenright@smcm.edu. FAU - Eick, Stephanie M AU - Eick SM AD - Gangarosa Department of Environmental Health, Rollins School of Public Health, Emory University, Atlanta, GA, USA. Electronic address: stephanie.marie.eick@emory.edu. FAU - Morello-Frosch, Rachel AU - Morello-Frosch R AD - Department of Environmental Science, Policy and Management and School of Public Health, University of California, Berkeley, Berkeley, CA, USA; Program on Reproductive Health and the Environment, Department of Obstetrics, Gynecology and Reproductive Sciences, University of California, San Francisco, San Francisco, CA, USA. FAU - Aguiar, Andrea AU - Aguiar A AD - Beckman Institute for Advanced Science and Technology, University of Illinois at Urbana-Champaign, Champaign, IL, USA; Department of Comparative Biosciences, University of Illinois at Urbana-Champaign, Champaign, IL, USA. FAU - Woodbury, Megan L AU - Woodbury ML AD - Beckman Institute for Advanced Science and Technology, University of Illinois at Urbana-Champaign, Champaign, IL, USA; College of Engineering, Northeastern University, Boston, MA, USA. FAU - Sprowles, Jenna L N AU - Sprowles JLN AD - Beckman Institute for Advanced Science and Technology, University of Illinois at Urbana-Champaign, Champaign, IL, USA; ICF, Durham, NC, USA. FAU - Geiger, Sarah Dee AU - Geiger SD AD - Beckman Institute for Advanced Science and Technology, University of Illinois at Urbana-Champaign, Champaign, IL, USA; Department of Kinesiology and Community Health, University of Illinois at Urbana-Champaign, Champaign, IL, USA. FAU - Trowbridge, Jessica AU - Trowbridge J AD - Program on Reproductive Health and the Environment, Department of Obstetrics, Gynecology and Reproductive Sciences, University of California, San Francisco, San Francisco, CA, USA. FAU - Andrade, Aileen AU - Andrade A AD - Program on Reproductive Health and the Environment, Department of Obstetrics, Gynecology and Reproductive Sciences, University of California, San Francisco, San Francisco, CA, USA. FAU - Smith, Sabrina AU - Smith S AD - Environmental Chemistry Laboratory, Department of Toxic Substances Control, California Environmental Protection Agency, Berkeley, CA, USA. FAU - Park, June-Soo AU - Park JS AD - Program on Reproductive Health and the Environment, Department of Obstetrics, Gynecology and Reproductive Sciences, University of California, San Francisco, San Francisco, CA, USA; Environmental Chemistry Laboratory, Department of Toxic Substances Control, California Environmental Protection Agency, Berkeley, CA, USA. FAU - DeMicco, Erin AU - DeMicco E AD - Program on Reproductive Health and the Environment, Department of Obstetrics, Gynecology and Reproductive Sciences, University of California, San Francisco, San Francisco, CA, USA. FAU - Padula, Amy M AU - Padula AM AD - Program on Reproductive Health and the Environment, Department of Obstetrics, Gynecology and Reproductive Sciences, University of California, San Francisco, San Francisco, CA, USA. FAU - Woodruff, Tracey J AU - Woodruff TJ AD - Program on Reproductive Health and the Environment, Department of Obstetrics, Gynecology and Reproductive Sciences, University of California, San Francisco, San Francisco, CA, USA. FAU - Schantz, Susan L AU - Schantz SL AD - Beckman Institute for Advanced Science and Technology, University of Illinois at Urbana-Champaign, Champaign, IL, USA; Department of Comparative Biosciences, University of Illinois at Urbana-Champaign, Champaign, IL, USA. LA - eng GR - P01 ES022841/ES/NIEHS NIH HHS/United States GR - U2C OD023375/OD/NIH HHS/United States GR - UG3 OD023272/OD/NIH HHS/United States GR - P30 ES030284/ES/NIEHS NIH HHS/United States GR - P30 ES019776/ES/NIEHS NIH HHS/United States GR - T32 ES007326/ES/NIEHS NIH HHS/United States GR - R01 ES027051/ES/NIEHS NIH HHS/United States GR - P01 ES022848/ES/NIEHS NIH HHS/United States GR - UH3 OD023272/OD/NIH HHS/United States PT - Journal Article PT - Research Support, N.I.H., Extramural PT - Research Support, Non-U.S. Gov't PT - Research Support, U.S. Gov't, Non-P.H.S. DEP - 20230510 PL - United States TA - Neurotoxicol Teratol JT - Neurotoxicology and teratology JID - 8709538 RN - 0 (Fluorocarbons) RN - 0 (Environmental Pollutants) SB - IM MH - Child MH - Female MH - Pregnancy MH - Humans MH - Infant MH - *Prenatal Exposure Delayed Effects/chemically induced MH - Bayes Theorem MH - *Fluorocarbons/toxicity MH - Cognition MH - Processing Speed MH - *Environmental Pollutants PMC - PMC10762627 MID - NIHMS1952064 OTO - NOTNLM OT - Infant cognition OT - PFAS OT - Per- and polyfluoroalkyl substances OT - Visual recognition memory COIS- Declaration of Competing Interest The authors declare the following financial interests/personal relationships which may be considered as potential competing interests: This work was supported by grants RD83543301 and RD83543401 from the United States Environmental Protection Agency Children's Environmental Health and Disease Prevention Research Center, P30 ES019776, P30 ES030284, P01 ES022841P01 ES022848 and R01ES02705 from the National Institute of Environmental Health Sciences, and UG3OD023272, UH3OD023272, and 5U2COD023375-05 from the National Institutes of Health Environmental influences on Child Health Outcomes (ECHO) program. Stephanie Eick's participation was partially supported by the JPB Environmental Health Fellowship. EDAT- 2023/05/13 15:13 MHDA- 2023/07/07 06:42 PMCR- 2024/07/01 CRDT- 2023/05/12 19:23 PHST- 2022/12/21 00:00 [received] PHST- 2023/04/07 00:00 [revised] PHST- 2023/05/09 00:00 [accepted] PHST- 2024/07/01 00:00 [pmc-release] PHST- 2023/07/07 06:42 [medline] PHST- 2023/05/13 15:13 [pubmed] PHST- 2023/05/12 19:23 [entrez] AID - S0892-0362(23)00032-6 [pii] AID - 10.1016/j.ntt.2023.107182 [doi] PST - ppublish SO - Neurotoxicol Teratol. 2023 Jul-Aug;98:107182. doi: 10.1016/j.ntt.2023.107182. Epub 2023 May 10.