PMID- 37173309
OWN - NLM
STAT- MEDLINE
DCOM- 20230515
LR  - 20230515
IS  - 2041-4889 (Electronic)
VI  - 14
IP  - 5
DP  - 2023 May 12
TI  - Clinical-grade human umbilical cord-derived mesenchymal stem cells improved 
      skeletal muscle dysfunction in age-associated sarcopenia mice.
PG  - 321
LID - 10.1038/s41419-023-05843-8 [doi]
LID - 321
AB  - With the expansion of the aging population, age-associated sarcopenia (AAS) has 
      become a severe clinical disease of the elderly and a key challenge for healthy 
      aging. Regrettably, no approved therapies currently exist for treating AAS. In 
      this study, clinical-grade human umbilical cord-derived mesenchymal stem cells 
      (hUC-MSCs) were administrated to two classic mouse models (SAMP8 mice and 
      D-galactose-induced aging mice), and their effects on skeletal muscle mass and 
      function were investigated by behavioral tests, immunostaining, and western 
      blotting. Core data results showed that hUC-MSCs significantly restored skeletal 
      muscle strength and performance in both mouse models via mechanisms including 
      raising the expression of crucial extracellular matrix proteins, activating 
      satellite cells, enhancing autophagy, and impeding cellular aging. For the first 
      time, the study comprehensively evaluates and demonstrates the preclinical 
      efficacy of clinical-grade hUC-MSCs for AAS in two mouse models, which not only 
      provides a novel model for AAS, but also highlights a promising strategy to 
      improve and treat AAS and other age-associated muscle diseases. This study 
      comprehensively evaluates the preclinical efficacy of clinical-grade hUC-MSCs in 
      treating age-associated sarcopenia (AAS), and demonstrates that hUC-MSCs restore 
      skeletal muscle strength and performance in two AAS mouse models via raising the 
      expression of extracellular matrix proteins, activating satellite cells, 
      enhancing autophagy, and impeding cellular aging, which highlights a promising 
      strategy for AAS and other age-associated muscle diseases.
CI  - (c) 2023. The Author(s).
FAU - Wang, Chao
AU  - Wang C
AD  - Stem Cell and Regenerative Medicine Lab, Beijing Institute of Radiation Medicine, 
      Beijing, 100850, China.
FAU - Zhao, Bichun
AU  - Zhao B
AD  - Stem Cell and Regenerative Medicine Lab, Beijing Institute of Radiation Medicine, 
      Beijing, 100850, China.
FAU - Zhai, Jinglei
AU  - Zhai J
AD  - State Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, 
      Chinese Academy of Sciences, Beijing, 100101, China.
FAU - Wang, Ailin
AU  - Wang A
AUID- ORCID: 0000-0003-4657-4301
AD  - Stem Cell and Regenerative Medicine Lab, Beijing Institute of Radiation Medicine, 
      Beijing, 100850, China.
FAU - Cao, Ning
AU  - Cao N
AD  - 920th Hospital of Joint Logistics Support Force, Kunming, 650032, China.
FAU - Liao, Tuling
AU  - Liao T
AD  - Stem Cell and Regenerative Medicine Lab, Beijing Institute of Radiation Medicine, 
      Beijing, 100850, China.
FAU - Su, Ruyu
AU  - Su R
AD  - South China Institute of Biomedicine, Guangzhou, 510005, China.
FAU - He, Lijuan
AU  - He L
AD  - Stem Cell and Regenerative Medicine Lab, Beijing Institute of Radiation Medicine, 
      Beijing, 100850, China.
AD  - South China Institute of Biomedicine, Guangzhou, 510005, China.
FAU - Li, Yanhua
AU  - Li Y
AD  - Stem Cell and Regenerative Medicine Lab, Beijing Institute of Radiation Medicine, 
      Beijing, 100850, China.
AD  - South China Institute of Biomedicine, Guangzhou, 510005, China.
FAU - Pei, Xuetao
AU  - Pei X
AUID- ORCID: 0000-0001-7717-3434
AD  - Stem Cell and Regenerative Medicine Lab, Beijing Institute of Radiation Medicine, 
      Beijing, 100850, China. peixt@nic.bmi.ac.cn.
AD  - South China Institute of Biomedicine, Guangzhou, 510005, China. 
      peixt@nic.bmi.ac.cn.
FAU - Jia, Yali
AU  - Jia Y
AUID- ORCID: 0000-0002-2896-6021
AD  - Stem Cell and Regenerative Medicine Lab, Beijing Institute of Radiation Medicine, 
      Beijing, 100850, China. jiayali2016@hotmail.com.
AD  - South China Institute of Biomedicine, Guangzhou, 510005, China. 
      jiayali2016@hotmail.com.
FAU - Yue, Wen
AU  - Yue W
AD  - Stem Cell and Regenerative Medicine Lab, Beijing Institute of Radiation Medicine, 
      Beijing, 100850, China. yuewen0206@126.com.
AD  - South China Institute of Biomedicine, Guangzhou, 510005, China. 
      yuewen0206@126.com.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20230512
PL  - England
TA  - Cell Death Dis
JT  - Cell death & disease
JID - 101524092
RN  - 0 (Extracellular Matrix Proteins)
SB  - IM
MH  - Humans
MH  - Mice
MH  - Animals
MH  - Aged
MH  - Cell Differentiation
MH  - *Sarcopenia/therapy
MH  - Muscle, Skeletal
MH  - *Mesenchymal Stem Cells/metabolism
MH  - Extracellular Matrix Proteins/metabolism
MH  - *Mesenchymal Stem Cell Transplantation/methods
MH  - Umbilical Cord
PMC - PMC10182022
COIS- The authors declare no competing interests.
EDAT- 2023/05/13 15:13
MHDA- 2023/05/15 06:42
PMCR- 2023/05/12
CRDT- 2023/05/12 23:15
PHST- 2022/09/26 00:00 [received]
PHST- 2023/04/28 00:00 [accepted]
PHST- 2023/04/23 00:00 [revised]
PHST- 2023/05/15 06:42 [medline]
PHST- 2023/05/13 15:13 [pubmed]
PHST- 2023/05/12 23:15 [entrez]
PHST- 2023/05/12 00:00 [pmc-release]
AID - 10.1038/s41419-023-05843-8 [pii]
AID - 5843 [pii]
AID - 10.1038/s41419-023-05843-8 [doi]
PST - epublish
SO  - Cell Death Dis. 2023 May 12;14(5):321. doi: 10.1038/s41419-023-05843-8.