PMID- 37173419
OWN - NLM
STAT- MEDLINE
DCOM- 20230515
LR  - 20230606
IS  - 2045-2322 (Electronic)
IS  - 2045-2322 (Linking)
VI  - 13
IP  - 1
DP  - 2023 May 12
TI  - Egyptian propolis extract for functionalization of cellulose nanofiber/poly(vinyl 
      alcohol) porous hydrogel along with characterization and biological applications.
PG  - 7739
LID - 10.1038/s41598-023-34901-6 [doi]
LID - 7739
AB  - Bee propolis is one of the most common natural extracts and has gained 
      significant interest in biomedicine due to its high content of phenolic acids and 
      flavonoids, which are responsible for the antioxidant activity of natural 
      products. The present study report that the propolis extract (PE) was produced by 
      ethanol in the surrounding environment. The obtained PE was added at different 
      concentrations to cellulose nanofiber (CNF)/poly(vinyl alcohol) (PVA), and 
      subjected to freezing thawing and freeze drying methods to develop porous 
      bioactive matrices. Scanning electron microscope (SEM) observations displayed 
      that the prepared samples had an interconnected porous structure with pore sizes 
      in the range of 10-100 mum. The high performance liquid chromatography (HPLC) 
      results of PE showed around 18 polyphenol compounds, with the highest amounts of 
      hesperetin (183.7 microg/mL), chlorogenic acid (96.9 microg/mL) and caffeic acid 
      (90.2 microg/mL). The antibacterial activity results indicated that both PE and 
      PE-functionalized hydrogels exhibited a potential antimicrobial effects against 
      Escherichia coli, Salmonella typhimurium, Streptococcus mutans, and Candida 
      albicans. The in vitro test cell culture experiments indicated that the cells on 
      the PE-functionalized hydrogels had the greatest viability, adhesion, and 
      spreading of cells. Altogether, these data highlight the interesting effect of 
      propolis bio-functionalization to enhance the biological features of CNF/PVA 
      hydrogel as a functional matrix for biomedical applications.
CI  - (c) 2023. The Author(s).
FAU - Saleh, Safaa
AU  - Saleh S
AD  - Department of Physics, Faculty of Science, Al-Azhar University, (Girls Branch), 
      P.O Box 11884, Cairo, Egypt.
FAU - Salama, Ahmed
AU  - Salama A
AD  - Cellulose and Paper Department, National Research Centre, 33 El-Bohouth St., 
      Dokki, P.O. 12622, Giza, Egypt.
FAU - Ali, Amira M
AU  - Ali AM
AD  - Department of Physics, Faculty of Science, Al-Azhar University, (Girls Branch), 
      P.O Box 11884, Cairo, Egypt.
FAU - Saleh, Ahmed K
AU  - Saleh AK
AD  - Cellulose and Paper Department, National Research Centre, 33 El-Bohouth St., 
      Dokki, P.O. 12622, Giza, Egypt. asrk_saleh@yahoo.com.
FAU - Elhady, Bothaina Abd
AU  - Elhady BA
AD  - Polymers and Pigments Department, National Research Centre, 33 El-Bohouth St., 
      Dokki, P.O. 12622, Giza, Egypt.
FAU - Tolba, Emad
AU  - Tolba E
AD  - Polymers and Pigments Department, National Research Centre, 33 El-Bohouth St., 
      Dokki, P.O. 12622, Giza, Egypt.
LA  - eng
PT  - Journal Article
DEP - 20230512
PL  - England
TA  - Sci Rep
JT  - Scientific reports
JID - 101563288
RN  - 9009-62-5 (Propolis)
RN  - 9002-89-5 (Polyvinyl Alcohol)
RN  - 9004-34-6 (Cellulose)
RN  - 0 (Plant Extracts)
RN  - 0 (Hydrogels)
SB  - IM
MH  - *Propolis/pharmacology/chemistry
MH  - Polyvinyl Alcohol/chemistry
MH  - Cellulose
MH  - Egypt
MH  - *Nanofibers
MH  - Porosity
MH  - Plant Extracts/chemistry
MH  - Hydrogels/chemistry
PMC - PMC10182032
COIS- The authors declare no competing interests.
EDAT- 2023/05/13 15:13
MHDA- 2023/05/15 06:42
PMCR- 2023/05/12
CRDT- 2023/05/12 23:21
PHST- 2022/12/07 00:00 [received]
PHST- 2023/05/09 00:00 [accepted]
PHST- 2023/05/15 06:42 [medline]
PHST- 2023/05/13 15:13 [pubmed]
PHST- 2023/05/12 23:21 [entrez]
PHST- 2023/05/12 00:00 [pmc-release]
AID - 10.1038/s41598-023-34901-6 [pii]
AID - 34901 [pii]
AID - 10.1038/s41598-023-34901-6 [doi]
PST - epublish
SO  - Sci Rep. 2023 May 12;13(1):7739. doi: 10.1038/s41598-023-34901-6.