PMID- 37173926
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20230515
IS  - 2072-6694 (Print)
IS  - 2072-6694 (Electronic)
IS  - 2072-6694 (Linking)
VI  - 15
IP  - 9
DP  - 2023 Apr 25
TI  - CD44, PDL1, and ATG7 Expression in Laryngeal Squamous Cell Carcinomas with Tissue 
      Microarray (TMA) Technique: Evaluation of the Potential Prognostic and Predictive 
      Roles.
LID - 10.3390/cancers15092461 [doi]
LID - 2461
AB  - We focus on the new prognostic and predictive factors CD44, PDL1, and ATG7 in our 
      study of surgical samples of patients with laryngeal squamous cell carcinoma 
      (LSCC) using tissue microarray (TMA). Thirty-nine previously untreated patients 
      affected by laryngeal carcinoma who then underwent surgical treatment were 
      considered in this retrospective study. All surgical specimens were sampled, 
      embedded in paraffin blocks, and stained with hematoxylin and eosin. A 
      representative sample of the tumor was chosen and transferred into a new block of 
      paraffin, the recipient block, to perform immunohistochemical analysis with the 
      primary antibodies anti-CD44, PD-L1, and ATG7. At follow-up, 5-year disease-free 
      survival (DFS) for negative and positive tumors was determined as 85.71% and 36% 
      for CD44, 60% and 33.33% for PDL1, and 58.06% and 37.50% for ATG7, respectively. 
      Multivariate analysis revealed that CD44 expression is an independent predictive 
      factor of low-grade tumors (p = 0.008), lymph node metastasis at the time of 
      diagnosis, and AGT7 negativity. Thus, CD44 expression is a potential marker for 
      more aggressive forms of laryngeal cancer.
FAU - Puzzo, Lidia
AU  - Puzzo L
AUID- ORCID: 0000-0002-0466-1389
AD  - Department "G.F. Ingrassia", Section of Anatomic Pathology, University of 
      Catania, 95123 Catania, Italy.
FAU - Bianco, Maria Rita
AU  - Bianco MR
AD  - Department of Medical and Surgical Sciences, Otolaryngology, University of 
      Catanzaro, 88100 Catanzaro, Italy.
FAU - Salvatorelli, Lucia
AU  - Salvatorelli L
AD  - Department "G.F. Ingrassia", Section of Anatomic Pathology, University of 
      Catania, 95123 Catania, Italy.
FAU - Tinnirello, Giordana
AU  - Tinnirello G
AUID- ORCID: 0009-0005-2680-1804
AD  - Department "G.F. Ingrassia", Section of Anatomic Pathology, University of 
      Catania, 95123 Catania, Italy.
FAU - Occhiuzzi, Federico
AU  - Occhiuzzi F
AD  - Department of Health Science, Otolaryngology, University of Catanzaro, 88100 
      Catanzaro, Italy.
FAU - Latella, Daniele
AU  - Latella D
AD  - Department of Health Science, Otolaryngology, University of Catanzaro, 88100 
      Catanzaro, Italy.
FAU - Allegra, Eugenia
AU  - Allegra E
AUID- ORCID: 0000-0002-5202-4333
AD  - Department of Health Science, Otolaryngology, University of Catanzaro, 88100 
      Catanzaro, Italy.
LA  - eng
PT  - Journal Article
DEP - 20230425
PL  - Switzerland
TA  - Cancers (Basel)
JT  - Cancers
JID - 101526829
PMC - PMC10177409
OTO - NOTNLM
OT  - ATG7
OT  - CD44
OT  - PDL1
OT  - biomarkers
OT  - laryngeal cancer
OT  - prognosis
COIS- The authors declare no conflict of interest.
EDAT- 2023/05/13 15:13
MHDA- 2023/05/13 15:14
PMCR- 2023/04/25
CRDT- 2023/05/13 01:18
PHST- 2023/03/11 00:00 [received]
PHST- 2023/04/10 00:00 [revised]
PHST- 2023/04/17 00:00 [accepted]
PHST- 2023/05/13 15:14 [medline]
PHST- 2023/05/13 15:13 [pubmed]
PHST- 2023/05/13 01:18 [entrez]
PHST- 2023/04/25 00:00 [pmc-release]
AID - cancers15092461 [pii]
AID - cancers-15-02461 [pii]
AID - 10.3390/cancers15092461 [doi]
PST - epublish
SO  - Cancers (Basel). 2023 Apr 25;15(9):2461. doi: 10.3390/cancers15092461.