PMID- 37178299 OWN - NLM STAT- MEDLINE DCOM- 20230614 LR - 20230614 IS - 1614-7499 (Electronic) IS - 0944-1344 (Linking) VI - 30 IP - 28 DP - 2023 Jun TI - Association between air pollutants with calcaneus ultrasound T-score change in a large Taiwanese population follow-up study. PG - 72607-72616 LID - 10.1007/s11356-023-27368-5 [doi] AB - Exposure to ambient air pollution has been associated with increased rates of mortality and morbidity and a shorter life expectancy. Few studies have evaluated the associations between air pollution and change in calcaneus ultrasound T-score (∆T-score). Therefore, in this longitudinal study, we explored these associations in a large group of Taiwanese participants. We used data from the Taiwan Biobank database and Taiwan Air Quality Monitoring Database, which contains detailed daily data on air pollution. We identified 27,033 participants in the Taiwan Biobank database who had both baseline and follow-up data. The median follow-up period was 4 years. The studied ambient air pollutants included particulates of 2.5 mum or less (PM(2.5)), particulates of 10 mum or less (PM(10)), ozone (O(3)), carbon monoxide (CO), sulfur dioxide (SO(2)), nitric oxide (NO), nitrogen dioxide (NO(2)), and nitrogen oxide (NO(x)). Multivariable analysis showed that PM(2.5) (beta, -0.003; 95% confidence interval (CI), -0.004 to -0.001; p < 0.001), PM(10) (beta, -0.005; 95% CI, -0.006 to -0.004, p < 0.001), O(3) (beta, -0.008; 95% CI, -0.011 to -0.004; p < 0.001), and SO(2) (beta, -0.036; 95% CI, -0.052 to -0.020; p < 0.001) were negatively associated with ∆T-score, and that CO (beta, 0.344; 95% CI, 0.254, 0.433; p < 0.001), NO (beta, 0.011; 95% CI, 0.008 to 0.015; p < 0.001), NO(2) (beta, 0.011; 95% CI, 0.008 to 0.014; p < 0.001), and NO(x) (beta, 0.007; 95% CI, 0.005 to 0.009; p < 0.001) were positively significantly associated with ∆T-score. Furthermore, PM(2.5) and SO(2) (beta, -0.014; 95% CI, -0.016 to -0.013; p < 0.001) and PM(10) and SO(2) (beta, -0.008; 95% CI, -0.009 to -0.007; p < 0.001) had synergistic negative effects on ∆T-score. In conclusion, we found that high PM(2.5), PM(10), O(3), and SO(2) were associated with a rapid decline in T-score, whereas high CO, NO, NO(2), and NO(x) were associated with a slow decline in T-score. Furthermore, PM(2.5) and SO(2) and PM(10) and SO(2) had synergistic negative effects on ∆T-score, causing an acceleration in T-score decline. These findings may be helpful when developing policies on air pollution regulation. CI - (c) 2023. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature. FAU - Su, Wei-Yu AU - Su WY AD - Department of General Medicine, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, 807, Taiwan. FAU - Wu, Da-Wei AU - Wu DW AD - Department of Internal Medicine, Kaohsiung Municipal Siaogang Hospital, Kaohsiung Medical University, Kaohsiung, 812, Taiwan. AD - Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, 807, Taiwan. FAU - Chen, Szu-Chia AU - Chen SC AUID- ORCID: 0000-0002-1610-4184 AD - Department of Internal Medicine, Kaohsiung Municipal Siaogang Hospital, Kaohsiung Medical University, Kaohsiung, 812, Taiwan. scarchenone@yahoo.com.tw. AD - Division of Nephrology, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, 807, Taiwan. scarchenone@yahoo.com.tw. AD - Faculty of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, 807, Taiwan. scarchenone@yahoo.com.tw. AD - Research Center for Precision Environmental Medicine, Kaohsiung Medical University, Kaohsiung, 807, Taiwan. scarchenone@yahoo.com.tw. FAU - Hung, Chih-Hsing AU - Hung CH AD - Research Center for Precision Environmental Medicine, Kaohsiung Medical University, Kaohsiung, 807, Taiwan. AD - Department of Pediatrics, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, 807, Taiwan. AD - Department of Pediatrics, Kaohsiung Municipal Siaogang Hospital, Kaohsiung Medical University, Kaohsiung, 812, Taiwan. FAU - Kuo, Chao-Hung AU - Kuo CH AD - Department of Internal Medicine, Kaohsiung Municipal Siaogang Hospital, Kaohsiung Medical University, Kaohsiung, 812, Taiwan. AD - Faculty of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, 807, Taiwan. AD - Division of Gastroenterology, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, 807, Taiwan. LA - eng GR - KMU-TC111A01/the Ministry of Education (MOE) in Taiwan and by Kaohsiung Medical University Research Center/ GR - KMUTC111IFSP01/the Ministry of Education (MOE) in Taiwan and by Kaohsiung Medical University Research Center/ PT - Journal Article DEP - 20230513 PL - Germany TA - Environ Sci Pollut Res Int JT - Environmental science and pollution research international JID - 9441769 RN - 0 (Air Pollutants) RN - S7G510RUBH (Nitrogen Dioxide) RN - 0UZA3422Q4 (Sulfur Dioxide) RN - 66H7ZZK23N (Ozone) RN - 31C4KY9ESH (Nitric Oxide) RN - 0 (Dust) RN - 0 (Particulate Matter) SB - IM MH - Humans MH - *Air Pollutants/analysis MH - Follow-Up Studies MH - Nitrogen Dioxide/analysis MH - Longitudinal Studies MH - *Calcaneus/chemistry MH - *Air Pollution/analysis MH - Sulfur Dioxide/analysis MH - *Ozone/analysis MH - Nitric Oxide MH - Dust MH - Particulate Matter/analysis MH - Environmental Exposure/analysis OTO - NOTNLM OT - Air pollutants OT - Follow-up OT - Osteoporosis OT - T-score OT - Taiwan Biobank EDAT- 2023/05/14 01:07 MHDA- 2023/06/14 06:42 CRDT- 2023/05/13 15:03 PHST- 2023/01/16 00:00 [received] PHST- 2023/04/27 00:00 [accepted] PHST- 2023/06/14 06:42 [medline] PHST- 2023/05/14 01:07 [pubmed] PHST- 2023/05/13 15:03 [entrez] AID - 10.1007/s11356-023-27368-5 [pii] AID - 10.1007/s11356-023-27368-5 [doi] PST - ppublish SO - Environ Sci Pollut Res Int. 2023 Jun;30(28):72607-72616. doi: 10.1007/s11356-023-27368-5. Epub 2023 May 13.