PMID- 37181481
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20230920
IS  - 2189-8448 (Print)
IS  - 2189-8448 (Electronic)
IS  - 2189-8448 (Linking)
VI  - 26
IP  - 1
DP  - 2023
TI  - Exertional Desaturation Is More Severe in Idiopathic Pulmonary Fibrosis Than in 
      Other Interstitial Lung Diseases.
PG  - 32-37
LID - 10.1298/ptr.E10218 [doi]
AB  - OBJECTIVE: Interstitial lung disease (ILD) is classified into several disease 
      groups. Among them, idiopathic pulmonary fibrosis (IPF) has higher incidence and 
      poor prognosis; therefore, it is important to characterize specific IPF symptoms. 
      Exercise desaturation is a strong factor related to mortality in patients with 
      ILD. Thus, the purpose of this study was to compare the degree of oxygen 
      desaturation between IPF and other ILD (non-IPF ILD) patients during exercise, 
      using the 6-minute walk test (6MWT). METHODS: This retrospective study included 
      126 stable patients with ILD who underwent 6MWT in our outpatient department. The 
      6MWT was used to assess desaturation during exercise, 6-minute walk distance 
      (6MWD), and dyspnea at the end of exercise. In addition, patient characteristics 
      and pulmonary function test results were recorded. RESULTS: Study subjects were 
      divided into 51 IPF patients and 75 non-IPF ILD patients. The IPF group had 
      significantly lower nadir oxygen saturation determined by pulse oximetry (SpO(2)) 
      during 6MWT than the non-IPF ILD group (IPF, 86.5 +/- 4.6%; non-IPF ILD, 88.7 +/- 
      5.3%; p = 0.02). The significant association between the nadir SpO(2) and IPF or 
      non-IPF ILD grouping remained even after adjusting for gender, age, body mass 
      index, lung function, 6MWD, and dyspnea (beta = -1.62; p <0.05). CONCLUSION: Even 
      after adjusting for confounding factors, IPF patients had lower nadir SpO(2) 
      during 6MWT. Early assessment of exercise desaturation using the 6MWT may be more 
      important in patients with IPF compared with patients with other ILDs.
CI  - (c)2023 Japanese Society of Physical Therapy.
FAU - Otake, Kohei
AU  - Otake K
AD  - Department of Rehabilitation, Kobe City Medical Center West Hospital, Japan.
FAU - Misu, Shogo
AU  - Misu S
AD  - Department of Physical Therapy, Faculty of Nursing and Rehabilitation, Konan 
      Women's University, Japan.
FAU - Fujikawa, Takashi
AU  - Fujikawa T
AD  - Department of Rehabilitation, Kobe City Medical Center West Hospital, Japan.
FAU - Sakai, Hideki
AU  - Sakai H
AD  - Department of Rehabilitation, Kobe City Medical Center General Hospital, Japan.
FAU - Tomioka, Hiromi
AU  - Tomioka H
AD  - Department of Respiratory Medicine, Kobe City Medical Center West Hospital, 
      Japan.
LA  - eng
PT  - Journal Article
DEP - 20230214
PL  - Japan
TA  - Phys Ther Res
JT  - Physical therapy research
JID - 101700769
PMC - PMC10169312
OTO - NOTNLM
OT  - 6-minute walk test
OT  - Idiopathic pulmonary fibrosis
OT  - Interstitial lung disease
OT  - Oxygen desaturation
COIS- There is no conflict of interest to disclose.
EDAT- 2023/05/14 19:13
MHDA- 2023/05/14 19:14
PMCR- 2023/02/14
CRDT- 2023/05/14 12:19
PHST- 2022/08/30 00:00 [received]
PHST- 2023/01/10 00:00 [accepted]
PHST- 2023/05/14 19:13 [pubmed]
PHST- 2023/05/14 19:14 [medline]
PHST- 2023/05/14 12:19 [entrez]
PHST- 2023/02/14 00:00 [pmc-release]
AID - ptr.E10218 [pii]
AID - 10.1298/ptr.E10218 [doi]
PST - ppublish
SO  - Phys Ther Res. 2023;26(1):32-37. doi: 10.1298/ptr.E10218. Epub 2023 Feb 14.