PMID- 37182299
OWN - NLM
STAT- MEDLINE
DCOM- 20230605
LR  - 20230605
IS  - 1090-2414 (Electronic)
IS  - 0147-6513 (Linking)
VI  - 259
DP  - 2023 Jul 1
TI  - Association between urinary metal concentrations and abnormal estimated 
      glomerular filtration rate in Chinese community-dwelling elderly: Exploring the 
      mediating effect of triglycerides.
PG  - 114966
LID - S0147-6513(23)00470-0 [pii]
LID - 10.1016/j.ecoenv.2023.114966 [doi]
AB  - BACKGROUND: Environmental metal exposure is associated with elevated 
      triglycerides (TG) and the development of chronic kidney disease (CKD). However, 
      the relationship between metal exposure and glomerular filtration rate (GFR) 
      remains uncertain, and the mediating effect of TG between the two is unclear. 
      METHODS: This study measured the concentrations of 14 metals in urine samples 
      from 3752 elderly people in the community. The most relevant metals were screened 
      by least absolute shrinkage and selection operator (LASSO) regression. The 
      relationship between combined exposure to multiple metals and abnormal estimated 
      glomerular filtration rate (eGFR) was explored using multivariate logistic 
      regression analysis and Bayesian kernel machine regression (BKMR) analysis. 
      Generalized linear regression models and the Karlson-Holm-Breen (KHB) method were 
      used to assess the mediating effects of TG. RESULTS: In the single-metal model, 
      calcium (Ca), iron (Fe), selenium (Se), strontium (Sr), and thallium (Tl) showed 
      significant negative correlations with the prevalence of abnormal eGFR (all 
      P < 0.05). In the multi-metals model, Ca, Se, and Tl continued to show 
      significant negative correlations, while vanadium (V) and zinc (Zn) showed 
      significant positive correlations with abnormal eGFR (all P < 0.05). The BKMR 
      model showed a negative joint effect of the mixture of Ca, V, Zn, Se, and Tl on 
      the prevalence of abnormal eGFR. The generalized linear regression model showed a 
      significant positive correlation between the concentrations of Ca (beta = 0.07), Zn 
      (beta = 0.07), Se (beta = 0.09), and TG levels (all P < 0.05). In the mediation 
      analysis, TG masked a 4.30% and 5.21% correlation between Ca and Se and the 
      prevalence of eGFR abnormalities, respectively. CONCLUSIONS: Urinary 
      concentration of multiple metals is significantly associated with eGFR 
      abnormalities, and Ca, and Se may be among the potential protective factors. TG 
      masked some of the protective effects of Ca and Se.
CI  - Copyright (c) 2023 The Authors. Published by Elsevier Inc. All rights reserved.
FAU - Shen, Zhuoheng
AU  - Shen Z
AD  - School of Public Health, Ningxia Medical University, Yinchuan Ningxia 750004, 
      P.R. China; Key Laboratory of Environmental Factors and Chronic Disease Control, 
      Yinchuan Ningxia 750004, P.R. China.
FAU - Wang, Rui
AU  - Wang R
AD  - School of Public Health, Ningxia Medical University, Yinchuan Ningxia 750004, 
      P.R. China; Key Laboratory of Environmental Factors and Chronic Disease Control, 
      Yinchuan Ningxia 750004, P.R. China.
FAU - He, Pei
AU  - He P
AD  - School of Public Health, Ningxia Medical University, Yinchuan Ningxia 750004, 
      P.R. China; Key Laboratory of Environmental Factors and Chronic Disease Control, 
      Yinchuan Ningxia 750004, P.R. China.
FAU - Zhang, Zhongyuan
AU  - Zhang Z
AD  - School of Public Health, Ningxia Medical University, Yinchuan Ningxia 750004, 
      P.R. China; Key Laboratory of Environmental Factors and Chronic Disease Control, 
      Yinchuan Ningxia 750004, P.R. China.
FAU - Dai, Yuqing
AU  - Dai Y
AD  - School of Public Health, Ningxia Medical University, Yinchuan Ningxia 750004, 
      P.R. China; Key Laboratory of Environmental Factors and Chronic Disease Control, 
      Yinchuan Ningxia 750004, P.R. China.
FAU - Li, Meiyan
AU  - Li M
AD  - School of Public Health, Ningxia Medical University, Yinchuan Ningxia 750004, 
      P.R. China; Key Laboratory of Environmental Factors and Chronic Disease Control, 
      Yinchuan Ningxia 750004, P.R. China.
FAU - Liu, Zhihong
AU  - Liu Z
AD  - School of Public Health, Ningxia Medical University, Yinchuan Ningxia 750004, 
      P.R. China; Key Laboratory of Environmental Factors and Chronic Disease Control, 
      Yinchuan Ningxia 750004, P.R. China.
FAU - Yang, Huifang
AU  - Yang H
AD  - School of Public Health, Ningxia Medical University, Yinchuan Ningxia 750004, 
      P.R. China; Key Laboratory of Environmental Factors and Chronic Disease Control, 
      Yinchuan Ningxia 750004, P.R. China.
FAU - Guan, Suzhen
AU  - Guan S
AD  - School of Public Health, Ningxia Medical University, Yinchuan Ningxia 750004, 
      P.R. China; Key Laboratory of Environmental Factors and Chronic Disease Control, 
      Yinchuan Ningxia 750004, P.R. China. Electronic address: guansz_nx2017@sina.com.
FAU - Sun, Jian
AU  - Sun J
AD  - School of Public Health, Ningxia Medical University, Yinchuan Ningxia 750004, 
      P.R. China; Key Laboratory of Environmental Factors and Chronic Disease Control, 
      Yinchuan Ningxia 750004, P.R. China. Electronic address: 20180016@nxmu.edu.cn.
LA  - eng
PT  - Journal Article
DEP - 20230512
PL  - Netherlands
TA  - Ecotoxicol Environ Saf
JT  - Ecotoxicology and environmental safety
JID - 7805381
RN  - SY7Q814VUP (Calcium)
RN  - H6241UJ22B (Selenium)
RN  - 0 (Triglycerides)
RN  - J41CSQ7QDS (Zinc)
RN  - 0 (Metals)
SB  - IM
MH  - Aged
MH  - Humans
MH  - Bayes Theorem
MH  - Calcium
MH  - East Asian People
MH  - *Glomerular Filtration Rate
MH  - Independent Living
MH  - Selenium
MH  - *Triglycerides
MH  - Zinc
MH  - *Metals/urine
OTO - NOTNLM
OT  - Cross-sectional study
OT  - Estimated glomerular filtration rate
OT  - Mediating effect
OT  - Triglycerides
OT  - Urine metals
COIS- Declaration of Competing Interest The authors declare that they have no known 
      competing financial interests or personal relationships that could have appeared 
      to influence the work reported in this paper.
EDAT- 2023/05/15 00:42
MHDA- 2023/06/05 06:42
CRDT- 2023/05/14 18:02
PHST- 2023/02/12 00:00 [received]
PHST- 2023/04/26 00:00 [revised]
PHST- 2023/04/27 00:00 [accepted]
PHST- 2023/06/05 06:42 [medline]
PHST- 2023/05/15 00:42 [pubmed]
PHST- 2023/05/14 18:02 [entrez]
AID - S0147-6513(23)00470-0 [pii]
AID - 10.1016/j.ecoenv.2023.114966 [doi]
PST - ppublish
SO  - Ecotoxicol Environ Saf. 2023 Jul 1;259:114966. doi: 10.1016/j.ecoenv.2023.114966. 
      Epub 2023 May 12.