PMID- 37182441
OWN - NLM
STAT- MEDLINE
DCOM- 20230529
LR  - 20230530
IS  - 1872-9142 (Electronic)
IS  - 0161-5890 (Linking)
VI  - 158
DP  - 2023 Jun
TI  - Analysis of type I hypersensitivity-induced inflammatory response in children of 
      different age groups with acute appendicitis.
PG  - 103-106
LID - S0161-5890(23)00097-4 [pii]
LID - 10.1016/j.molimm.2023.05.002 [doi]
AB  - OBJECTIVE: To explore the differences in type I hypersensitivity-induced 
      inflammatory response among children of different age groups with acute 
      appendicitis. METHODS: We selected children diagnosed with "acute appendicitis" 
      who underwent surgery in the Department of General Surgery of Anhui Provincial 
      Children's Hospital from January 2022 to June 2022 and collected their basic 
      data. We divided them into two groups according to age: the infant group (less 
      than 3 years old) and the pediatric group (3-14 years old). The gender, age, 
      onset time, hospital stay, preoperative white blood cells, percentage of 
      neutrophils, C-reactive protein (CRP), and enzyme-linked immunosorbent assay 
      (ELISA) were collected to determine the levels of immunoglobulin E (IgE), 
      interleukin-4 (IL-4), interleukin-5 (IL-5), interleukin-6 (IL-6), and 
      interleukin-9 (IL-9) in appendicular lavage fluid, and the differences between 
      the two groups were compared. RESULTS: There were 15 children in the infant group 
      and 15 in the pediatric group. There was no significant difference between the 
      two groups with respect to onset time and gender. The hospitalization time in the 
      pediatric group was (5.7 +/- 2.1) d, the preoperative white blood cells were 
      (14.3 +/- 3.7) x 10;9/mL, neutrophil percentage was (84.5 +/- 6.3)%, and CRP was 
      (20.0 +/- 17.9) mg/mL. The hospitalization time of the infant group was (8.0 +/- 3.1) 
      d, the preoperative white blood cells were (19.0 +/- 3.8) x 10;9/mL, neutrophil 
      percentage was (77.8 +/- 10.4)%, and CRP was (42.5 +/- 25.0) mg/mL. The differences 
      between the two groups were significant. There was no significant difference in 
      IL-5 concentration between the two groups in the appendicular lavage fluid. IgE 
      (610.74 +/- 72.56) ng/mL, IL-4 (30.80 +/- 12.04) ng/mL, IL-6 (118.09 +/- 14.29) ng/mL, 
      IL-9 (133.94 +/- 16.00) ng/mL were found in the infant group, and IgE 
      (495.61 +/- 95.09) ng/mL, IL-4 (22.68 +/- 7.05) ng/mL, IL-6 (98.22 +/- 22.18) ng/mL and 
      IL-9 (107.86 +/- 27.34) ng/mL were found in the pediatric group, and the 
      differences between the two groups were statistically significant. CONCLUSIONS: 
      The inflammatory response in children with acute appendicitis was associated with 
      type I hypersensitivity-induced inflammatory responses, and the type I 
      hypersensitivity was more intense in children in the lower age group.
CI  - Copyright (c) 2023 The Authors. Published by Elsevier Ltd.. All rights reserved.
FAU - Pan, Zhu-Bin
AU  - Pan ZB
AD  - Department of General Surgery, Anhui Provincial Children's Hospital, Children's 
      Hospital of Fudan University Anhui Hospital, Children's Hospital of Anhui Medical 
      University, Hefei 230000, China. Electronic address: panzhubinpzb9@126.com.
FAU - Zhang, Tao
AU  - Zhang T
AD  - Department of General Surgery, Anhui Provincial Children's Hospital, Children's 
      Hospital of Fudan University Anhui Hospital, Children's Hospital of Anhui Medical 
      University, Hefei 230000, China.
FAU - Yuan Cheng, M M
AU  - Yuan Cheng MM
AD  - Department of General Surgery, Anhui Provincial Children's Hospital, Children's 
      Hospital of Fudan University Anhui Hospital, Children's Hospital of Anhui Medical 
      University, Hefei 230000, China.
FAU - Yu-Liang Zhou, M M
AU  - Yu-Liang Zhou MM
AD  - Department of General Surgery, Anhui Provincial Children's Hospital, Children's 
      Hospital of Fudan University Anhui Hospital, Children's Hospital of Anhui Medical 
      University, Hefei 230000, China.
FAU - Zhen-Qiang Zhang, M M
AU  - Zhen-Qiang Zhang MM
AD  - Department of General Surgery, Anhui Provincial Children's Hospital, Children's 
      Hospital of Fudan University Anhui Hospital, Children's Hospital of Anhui Medical 
      University, Hefei 230000, China.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20230512
PL  - England
TA  - Mol Immunol
JT  - Molecular immunology
JID - 7905289
RN  - 207137-56-2 (Interleukin-4)
RN  - 0 (Interleukin-9)
RN  - 0 (Interleukin-5)
RN  - 0 (Interleukin-6)
RN  - 9007-41-4 (C-Reactive Protein)
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
MH  - Infant
MH  - Humans
MH  - Child
MH  - Child, Preschool
MH  - Adolescent
MH  - Interleukin-4
MH  - Interleukin-9
MH  - Interleukin-5
MH  - Interleukin-6
MH  - *Appendicitis/surgery/diagnosis
MH  - C-Reactive Protein/metabolism
MH  - *Hypersensitivity
MH  - Acute Disease
MH  - *Hypersensitivity, Immediate
MH  - Immunoglobulin E
OTO - NOTNLM
OT  - Appendicitis
OT  - Childhood
OT  - IgE
OT  - Immunohistochemistry
OT  - Pathology
OT  - Type I hypersensitivity
COIS- Competing interests The authors declare that they have no competing interests.
EDAT- 2023/05/15 00:42
MHDA- 2023/05/29 06:42
CRDT- 2023/05/14 18:08
PHST- 2023/02/23 00:00 [received]
PHST- 2023/04/23 00:00 [revised]
PHST- 2023/05/04 00:00 [accepted]
PHST- 2023/05/29 06:42 [medline]
PHST- 2023/05/15 00:42 [pubmed]
PHST- 2023/05/14 18:08 [entrez]
AID - S0161-5890(23)00097-4 [pii]
AID - 10.1016/j.molimm.2023.05.002 [doi]
PST - ppublish
SO  - Mol Immunol. 2023 Jun;158:103-106. doi: 10.1016/j.molimm.2023.05.002. Epub 2023 
      May 12.