PMID- 37183941
OWN - NLM
STAT- MEDLINE
DCOM- 20230516
LR  - 20230516
IS  - 1607-8454 (Electronic)
IS  - 1024-5332 (Linking)
VI  - 28
IP  - 1
DP  - 2023 Dec
TI  - Polymorphisms of inflammation-related genes and susceptibility to childhood 
      leukemia: evidence from a meta-analysis of 16 published studies.
PG  - 2210905
LID - 10.1080/16078454.2023.2210905 [doi]
AB  - OBJECTIVE: This study was to comprehensively clarify the associations between 
      single nucleotide polymorphisms (SNPs) in inflammatory genes and the 
      susceptibility to childhood leukemia. METHODS: Eligible articles were collected 
      from the databases of PubMed, EMBASE, Cochrane Library, CNKI and Wan Fang. The 
      pooled odds ratios (ORs) and 95% con fi dence intervals (95% CIs) were calculated to 
      estimate the association strength by using the STATA 15.0 software. RESULTS: 
      Sixteen studies were enrolled. These studies mainly evaluated SNPs in 13 genes, 
      including C-X-C motif chemokine ligand 12 (CXCL12), toll-like receptor (TLR)-4, 
      TLR6, TLR9, CD14, interleukin (IL)-1beta, NLR family pyrin domain containing 3, 
      IL-4, interleukin 4 receptor, IL-10, IL-13, macrophage migration inhibitory 
      factor (MIF) and tumor necrosis factor-alpha. The meta-analysis indicated that CXCL12 
      rs1801157 (AG vs GG: OR = 1.99; 95%CI = 1.20-3.30; p = 0.008; AA + AG vs GG: 
      OR = 1.92; 95%CI = 1.18-3.12; p = 0.009), TLR6 rs5743810 (TC vs TT: OR = 0.58; 
      95%CI = 0.39-0.85; p = 0.005), IL-10 rs1800871 (TC vs CC: OR = 1.19; 
      95%CI = 1.01-1.41; p = 0.044), rs1800872 (AC vs AA: OR = 1.53; 95%CI = 1.22-1.92; 
      p < 0.001) and MIF rs755622 (CG versus GG: OR = 1.33; 95%CI = 1.07-1.67; 
      p = 0.012) polymorphisms were associated with the risk of childhood leukemia. No 
      significant correlations were found between SNPs in other genes and the childhood 
      leukemia risk. Subgroup analyses of rs1800871 and rs1800872 confirmed the 
      conclusions obtained in their overall meta-analytical processes. CONCLUSION: 
      CXCL12 rs1801157, TLR6 rs5743810, IL-10 rs1800871, rs1800872 and MIF rs755622 
      polymorphisms may represent candidate biomarkers for the risk prediction of 
      childhood leukemia.
FAU - Zeng, Qiuping
AU  - Zeng Q
AD  - Department of Pediatric Hematology and Rheumatology, Zhuhai Center for Maternal 
      and Child Health Care, Zhuhai, People's Republic of China.
FAU - Ren, Haoyan
AU  - Ren H
AD  - Department of Pediatric Hematology and Rheumatology, Zhuhai Center for Maternal 
      and Child Health Care, Zhuhai, People's Republic of China.
FAU - Liu, Cui
AU  - Liu C
AD  - Department of Pediatrics, Qingdao Huangdao District Central Hospital, Qingdao, 
      People's Republic of China.
FAU - Liu, Ting
AU  - Liu T
AD  - Department of Pediatric Hematology and Rheumatology, Zhuhai Center for Maternal 
      and Child Health Care, Zhuhai, People's Republic of China.
FAU - Xie, Yongwu
AU  - Xie Y
AD  - Department of Pediatric Hematology and Rheumatology, Zhuhai Center for Maternal 
      and Child Health Care, Zhuhai, People's Republic of China.
FAU - Tang, Xiufu
AU  - Tang X
AD  - Department of Pediatric Hematology and Rheumatology, Zhuhai Center for Maternal 
      and Child Health Care, Zhuhai, People's Republic of China.
LA  - eng
PT  - Journal Article
PT  - Meta-Analysis
PT  - Review
PL  - England
TA  - Hematology
JT  - Hematology (Amsterdam, Netherlands)
JID - 9708388
RN  - 130068-27-8 (Interleukin-10)
RN  - 0 (Toll-Like Receptor 6)
SB  - IM
MH  - Humans
MH  - *Interleukin-10/genetics
MH  - *Toll-Like Receptor 6/genetics
MH  - Genetic Predisposition to Disease
MH  - Polymorphism, Single Nucleotide
MH  - Inflammation
OTO - NOTNLM
OT  - Childhood leukemia
OT  - IL-10
OT  - inflammation
OT  - meta-analysis
OT  - polymorphism
EDAT- 2023/05/15 13:05
MHDA- 2023/05/16 06:42
CRDT- 2023/05/15 06:44
PHST- 2023/05/16 06:42 [medline]
PHST- 2023/05/15 13:05 [pubmed]
PHST- 2023/05/15 06:44 [entrez]
AID - 10.1080/16078454.2023.2210905 [doi]
PST - ppublish
SO  - Hematology. 2023 Dec;28(1):2210905. doi: 10.1080/16078454.2023.2210905.