PMID- 37184982
OWN - NLM
STAT- MEDLINE
DCOM- 20230531
LR  - 20230601
IS  - 1520-5851 (Electronic)
IS  - 0013-936X (Linking)
VI  - 57
IP  - 21
DP  - 2023 May 30
TI  - PM(2.5) Increases Systemic Inflammatory Cells and Associated Disease Risks by 
      Inducing NRF2-Dependent Myeloid-Biased Hematopoiesis in Adult Male Mice.
PG  - 7924-7937
LID - 10.1021/acs.est.2c09024 [doi]
AB  - Although PM(2.5) (fine particles with aerodynamic diameter <2.5 mum) exposure 
      shows the potential to impact normal hematopoiesis, the detailed alterations in 
      systemic hematopoiesis and the underlying mechanisms remain unclear. For 
      hematopoiesis under steady-state or stress conditions, nuclear factor erythroid 
      2-related factor 2 (NRF2) is essential for regulating hematopoietic processes to 
      maintain blood homeostasis. Herein, we characterized changes in the populations 
      of hematopoietic stem progenitor cells and committed hematopoietic progenitors in 
      the lungs and bone marrow (BM) of wild-type and Nrf2(-/-) C57BL/6J male mice. 
      PM(2.5)-induced NRF2-dependent biased hematopoiesis toward myeloid lineage in the 
      lungs and BM generates excessive numbers of various inflammatory immune cells, 
      including neutrophils, monocytes, and platelets. The increased population of 
      these immune cells in the lungs, BM, and peripheral blood has been associated 
      with observed pulmonary fibrosis and high disease risks in an NRF2-dependent 
      manner. Therefore, although NRF2 is a protective factor against stressors, upon 
      PM(2.5) exposure, NRF2 is involved in stress myelopoiesis and enhanced PM(2.5) 
      toxicity in pulmonary injury, even leading to systemic inflammation.
FAU - Wang, Yuanyuan
AU  - Wang Y
AD  - State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research 
      Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing 
      100085, China.
AD  - College of Resources and Environment, University of Chinese Academy of Sciences, 
      Beijing 100049, China.
FAU - Jin, Xiaoting
AU  - Jin X
AD  - School of Public Health, Qingdao University, Qingdao 266071, China.
FAU - Li, Min
AU  - Li M
AD  - State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research 
      Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing 
      100085, China.
AD  - Research Center for Analytical Sciences, Department of Chemistry, College of 
      Sciences, Northeastern University, Shenyang 110819, China.
FAU - Gao, Jie
AU  - Gao J
AD  - State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research 
      Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing 
      100085, China.
AD  - School of Environmental, Hangzhou Institute for Advanced Study, UCAS, Hangzhou 
      310000, China.
FAU - Zhao, Xingchen
AU  - Zhao X
AUID- ORCID: 0000-0001-6441-9394
AD  - State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research 
      Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing 
      100085, China.
FAU - Ma, Juan
AU  - Ma J
AD  - State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research 
      Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing 
      100085, China.
AD  - College of Resources and Environment, University of Chinese Academy of Sciences, 
      Beijing 100049, China.
FAU - Shi, Chunzhen
AU  - Shi C
AD  - State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research 
      Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing 
      100085, China.
AD  - College of Ecology and Environment, Beijing Technology and Business University, 
      Beijing 100048, China.
FAU - He, Bin
AU  - He B
AUID- ORCID: 0000-0002-7071-7563
AD  - State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research 
      Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing 
      100085, China.
AD  - School of Environmental, Hangzhou Institute for Advanced Study, UCAS, Hangzhou 
      310000, China.
AD  - College of Resources and Environment, University of Chinese Academy of Sciences, 
      Beijing 100049, China.
FAU - Hu, Ligang
AU  - Hu L
AUID- ORCID: 0000-0002-6213-4720
AD  - State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research 
      Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing 
      100085, China.
AD  - School of Environmental, Hangzhou Institute for Advanced Study, UCAS, Hangzhou 
      310000, China.
AD  - College of Resources and Environment, University of Chinese Academy of Sciences, 
      Beijing 100049, China.
AD  - Institute of Environment and Health, Jianghan University, Wuhan 430056, China.
FAU - Shi, Jianbo
AU  - Shi J
AUID- ORCID: 0000-0003-2637-1929
AD  - State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research 
      Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing 
      100085, China.
AD  - School of Environmental, Hangzhou Institute for Advanced Study, UCAS, Hangzhou 
      310000, China.
AD  - College of Resources and Environment, University of Chinese Academy of Sciences, 
      Beijing 100049, China.
AD  - Institute of Environment and Health, Jianghan University, Wuhan 430056, China.
FAU - Liu, Guoliang
AU  - Liu G
AD  - Department of Pulmonary and Critical Care Medicine, National Center of 
      Respiratory Medicine, China-Japan Friendship Hospital, Beijing 100029, China.
AD  - Institute of Respiratory Medicine, National Clinical Research Center for 
      Respiratory Diseases, Chinese Academy of Medical Sciences, Beijing 100029, China.
FAU - Qu, Guangbo
AU  - Qu G
AUID- ORCID: 0000-0002-5220-7009
AD  - State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research 
      Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing 
      100085, China.
AD  - School of Environmental, Hangzhou Institute for Advanced Study, UCAS, Hangzhou 
      310000, China.
AD  - College of Resources and Environment, University of Chinese Academy of Sciences, 
      Beijing 100049, China.
AD  - Institute of Environment and Health, Jianghan University, Wuhan 430056, China.
FAU - Zheng, Yuxin
AU  - Zheng Y
AD  - School of Public Health, Qingdao University, Qingdao 266071, China.
FAU - Jiang, Guibin
AU  - Jiang G
AUID- ORCID: 0000-0002-6335-3917
AD  - State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research 
      Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing 
      100085, China.
AD  - School of Environmental, Hangzhou Institute for Advanced Study, UCAS, Hangzhou 
      310000, China.
AD  - College of Resources and Environment, University of Chinese Academy of Sciences, 
      Beijing 100049, China.
AD  - Institute of Environment and Health, Jianghan University, Wuhan 430056, China.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20230515
PL  - United States
TA  - Environ Sci Technol
JT  - Environmental science & technology
JID - 0213155
RN  - 0 (NF-E2-Related Factor 2)
RN  - 0 (Particulate Matter)
SB  - IM
MH  - Mice
MH  - Male
MH  - Animals
MH  - *NF-E2-Related Factor 2
MH  - Mice, Inbred C57BL
MH  - *Hematopoiesis/physiology
MH  - Hematopoietic Stem Cells
MH  - Particulate Matter/toxicity
OTO - NOTNLM
OT  - NRF2
OT  - PM2.5
OT  - hematopoiesis
OT  - immune system
OT  - lung
EDAT- 2023/05/15 19:12
MHDA- 2023/05/31 06:42
CRDT- 2023/05/15 12:23
PHST- 2023/05/31 06:42 [medline]
PHST- 2023/05/15 19:12 [pubmed]
PHST- 2023/05/15 12:23 [entrez]
AID - 10.1021/acs.est.2c09024 [doi]
PST - ppublish
SO  - Environ Sci Technol. 2023 May 30;57(21):7924-7937. doi: 10.1021/acs.est.2c09024. 
      Epub 2023 May 15.