PMID- 37185565
OWN - NLM
STAT- MEDLINE
DCOM- 20230517
LR  - 20230728
IS  - 2079-6374 (Electronic)
IS  - 2079-6374 (Linking)
VI  - 13
IP  - 4
DP  - 2023 Apr 19
TI  - An Electrochemical Screen-Printed Sensor Based on Gold-Nanoparticle-Decorated 
      Reduced Graphene Oxide-Carbon Nanotubes Composites for the Determination of 17-beta 
      Estradiol.
LID - 10.3390/bios13040491 [doi]
LID - 491
AB  - In this study, a screen-printed electrode (SPE) modified with 
      gold-nanoparticle-decorated reduced graphene oxide-carbon nanotubes 
      (rGO-AuNPs/CNT/SPE) was used for the determination of estradiol (E2). The AuNPs 
      were produced through an eco-friendly method utilising plant extract, eliminating 
      the need for severe chemicals, and remove the requirements of sophisticated 
      fabrication methods and tedious procedures. In addition, rGO-AuNP serves as a 
      dispersant for the CNT to improve the dispersion stability of CNTs. The composite 
      material, rGO-AuNPs/CNT, underwent characterisation through scanning electron 
      microscopy (SEM), ultraviolet-visible absorption spectroscopy (UV-vis), 
      Fourier-transform infrared (FTIR) spectroscopy, and atomic force microscopy 
      (AFM). The electrochemical performance of the modified SPE for estradiol 
      oxidation was characterised using cyclic voltammetry (CV) and differential pulse 
      voltammetry (DPV) techniques. The rGO-AuNPs/CNT/SPE exhibited a notable 
      improvement compared to bare/SPE and GO-CNT/SPE, as evidenced by the relative 
      peak currents. Additionally, we employed a baseline correction algorithm to 
      accurately adjust the sensor response while eliminating extraneous background 
      components that are typically present in voltammetric experiments. The optimised 
      estradiol sensor offers linear sensitivity from 0.05-1.00 microM, with a detection 
      limit of 3 nM based on three times the standard deviation (3delta). Notably, this 
      sensing approach yields stable, repeatable, and reproducible outcomes. Assessment 
      of drinking water samples indicated an average recovery rate of 97.5% for samples 
      enriched with E2 at concentrations as low as 0.5 microM%, accompanied by only a 
      modest coefficient of variation (%CV) value of 2.7%.
FAU - Musa, Auwal M
AU  - Musa AM
AD  - Institute of Bio-Sensing Technology (IBST), University of the West of England, 
      Bristol BS16 1QY, UK.
FAU - Kiely, Janice
AU  - Kiely J
AD  - Centre for Research in Biosciences (CRIB), School of Applied Sciences, University 
      of the West of England, Bristol BS16 1QY, UK.
FAU - Luxton, Richard
AU  - Luxton R
AD  - Centre for Research in Biosciences (CRIB), School of Applied Sciences, University 
      of the West of England, Bristol BS16 1QY, UK.
FAU - Honeychurch, Kevin C
AU  - Honeychurch KC
AUID- ORCID: 0000-0002-6363-7178
AD  - Institute of Bio-Sensing Technology (IBST), University of the West of England, 
      Bristol BS16 1QY, UK.
AD  - Centre for Research in Biosciences (CRIB), School of Applied Sciences, University 
      of the West of England, Bristol BS16 1QY, UK.
LA  - eng
PT  - Journal Article
DEP - 20230419
PL  - Switzerland
TA  - Biosensors (Basel)
JT  - Biosensors
JID - 101609191
RN  - 0 (Nanotubes, Carbon)
RN  - 0 (graphene oxide)
RN  - 7440-57-5 (Gold)
RN  - 4TI98Z838E (Estradiol)
RN  - 7782-42-5 (Graphite)
SB  - IM
EIN - Biosensors (Basel). 2023 Jul 24;13(7):. PMID: 37504155
MH  - *Nanotubes, Carbon/chemistry
MH  - Gold/chemistry
MH  - *Metal Nanoparticles/chemistry
MH  - Estradiol
MH  - *Graphite/chemistry
MH  - Electrodes
MH  - Electrochemical Techniques/methods
PMC - PMC10136424
OTO - NOTNLM
OT  - carbon nanotubes
OT  - disposable screen-printed electrodes
OT  - estradiol
OT  - gold nanoparticles
OT  - graphene oxide
COIS- The authors declare no conflict of interest.
EDAT- 2023/05/15 19:12
MHDA- 2023/05/17 06:42
PMCR- 2023/04/19
CRDT- 2023/05/15 13:38
PHST- 2023/03/14 00:00 [received]
PHST- 2023/04/07 00:00 [revised]
PHST- 2023/04/10 00:00 [accepted]
PHST- 2023/05/17 06:42 [medline]
PHST- 2023/05/15 19:12 [pubmed]
PHST- 2023/05/15 13:38 [entrez]
PHST- 2023/04/19 00:00 [pmc-release]
AID - bios13040491 [pii]
AID - biosensors-13-00491 [pii]
AID - 10.3390/bios13040491 [doi]
PST - epublish
SO  - Biosensors (Basel). 2023 Apr 19;13(4):491. doi: 10.3390/bios13040491.