PMID- 37186333 OWN - NLM STAT- MEDLINE DCOM- 20230517 LR - 20240403 IS - 1399-3038 (Electronic) IS - 0905-6157 (Linking) VI - 34 Suppl 28 DP - 2023 Mar TI - EAACI Molecular Allergology User's Guide 2.0. PG - e13854 LID - 10.1111/pai.13854 [doi] AB - Since the discovery of immunoglobulin E (IgE) as a mediator of allergic diseases in 1967, our knowledge about the immunological mechanisms of IgE-mediated allergies has remarkably increased. In addition to understanding the immune response and clinical symptoms, allergy diagnosis and management depend strongly on the precise identification of the elicitors of the IgE-mediated allergic reaction. In the past four decades, innovations in bioscience and technology have facilitated the identification and production of well-defined, highly pure molecules for component-resolved diagnosis (CRD), allowing a personalized diagnosis and management of the allergic disease for individual patients. The first edition of the "EAACI Molecular Allergology User's Guide" (MAUG) in 2016 rapidly became a key reference for clinicians, scientists, and interested readers with a background in allergology, immunology, biology, and medicine. Nevertheless, the field of molecular allergology is moving fast, and after 6 years, a new EAACI Taskforce was established to provide an updated document. The Molecular Allergology User's Guide 2.0 summarizes state-of-the-art information on allergen molecules, their clinical relevance, and their application in diagnostic algorithms for clinical practice. It is designed for both, clinicians and scientists, guiding health care professionals through the overwhelming list of different allergen molecules available for testing. Further, it provides diagnostic algorithms on the clinical relevance of allergenic molecules and gives an overview of their biology, the basic mechanisms of test formats, and the application of tests to measure allergen exposure. CI - (c) 2023 The Authors. Pediatric Allergy and Immunology published by European Academy of Allergy and Clinical Immunology and John Wiley & Sons Ltd. FAU - Dramburg, Stephanie AU - Dramburg S AUID- ORCID: 0000-0002-9303-3260 AD - Department of Pediatric Respiratory Medicine, Immunology and Critical Care Medicine, Charite Universitatsmedizin Berlin, Berlin, Germany. FAU - Hilger, Christiane AU - Hilger C AUID- ORCID: 0000-0001-9455-5442 AD - Department of Infection and Immunity, Luxembourg Institute of Health, Esch-sur-Alzette, Luxembourg. FAU - Santos, Alexandra F AU - Santos AF AUID- ORCID: 0000-0002-7805-1436 AD - Department of Women and Children's Health (Pediatric Allergy), School of Life Course Sciences, Faculty of Life Sciences and Medicine, King's College London, London, United Kingdom. AD - Peter Gorer Department of Immunobiology, School of Immunology and Microbial Sciences, King's College London, London, United Kingdom. AD - Children's Allergy Service, Evelina London, Guy's and St Thomas' Hospital, London, United Kingdom. FAU - de Las Vecillas, Leticia AU - de Las Vecillas L AUID- ORCID: 0000-0003-4969-5678 AD - Department of Allergy, La Paz University Hospital, IdiPAZ, Madrid, Spain. FAU - Aalberse, Rob C AU - Aalberse RC AUID- ORCID: 0000-0002-3902-6596 AD - Sanquin Research, Dept Immunopathology, University of Amsterdam, Amsterdam, The Netherlands. AD - Landsteiner Laboratory, Academic Medical Centre, University of Amsterdam, Amsterdam, The Netherlands. FAU - Acevedo, Nathalie AU - Acevedo N AUID- ORCID: 0000-0002-5154-2964 AD - Institute for Immunological Research, University of Cartagena, Cartagena de Indias, Colombia, Colombia. FAU - Aglas, Lorenz AU - Aglas L AUID- ORCID: 0000-0002-1236-5934 AD - Department of Biosciences and Medical Biology, Paris Lodron University Salzburg, Salzburg, Austria. FAU - Altmann, Friedrich AU - Altmann F AUID- ORCID: 0000-0002-0112-7877 AD - Department of Chemistry, University of Natural Resources and Life Sciences, Vienna, Austria. FAU - Arruda, Karla L AU - Arruda KL AUID- ORCID: 0000-0002-7505-210X AD - Department of Medicine, Ribeirao Preto Medical School, University of Sao Paulo, Ribeirao Preto, Sao Paulo, Brasil, Brazil. FAU - Asero, Riccardo AU - Asero R AUID- ORCID: 0000-0002-8277-1700 AD - Ambulatorio di Allergologia, Clinica San Carlo, Paderno Dugnano, Italy. FAU - Ballmer-Weber, Barbara AU - Ballmer-Weber B AUID- ORCID: 0000-0002-4136-5036 AD - Klinik fur Dermatologie und Allergologie, Kantonsspital St. Gallen, St. Gallen, Switzerland. AD - Department of Dermatology, University Hospital Zurich, Zurich, Switzerland. FAU - Barber, Domingo AU - Barber D AUID- ORCID: 0000-0002-5488-5700 AD - Institute of Applied Molecular Medicine Nemesio Diez (IMMAND), Department of Basic Medical Sciences, Facultad de Medicina, Universidad San Pablo CEU, CEU Universities, Madrid, Spain. AD - RETIC ARADyAL and RICORS Enfermedades Inflamatorias (REI), Madrid, Spain. FAU - Beyer, Kirsten AU - Beyer K AUID- ORCID: 0000-0003-1859-0419 AD - Department of Pediatric Respiratory Medicine, Immunology and Critical Care Medicine, Charite Universitatsmedizin Berlin, Berlin, Germany. FAU - Biedermann, Tilo AU - Biedermann T AUID- ORCID: 0000-0002-5352-5105 AD - Department of Dermatology and Allergy Biederstein, School of Medicine, Technical University Munich, Munich, Germany. FAU - Bilo, Maria Beatrice AU - Bilo MB AUID- ORCID: 0000-0002-9324-6039 AD - Department of Clinical and Molecular Sciences, Universita Politecnica delle Marche, Ancona, Italy. AD - Allergy Unit Department of Internal Medicine, University Hospital Ospedali Riuniti di Ancona, Torrette, Italy. FAU - Blank, Simon AU - Blank S AUID- ORCID: 0000-0002-5649-1078 AD - Center of Allergy and Environment (ZAUM), Technical University of Munich, School of Medicine and Helmholtz Center Munich, German Research Center for Environmental Health, Munich, Germany. FAU - Bosshard, Philipp P AU - Bosshard PP AUID- ORCID: 0000-0002-1154-2281 AD - Department of Dermatology, University Hospital Zurich, Zurich, Switzerland. FAU - Breiteneder, Heimo AU - Breiteneder H AUID- ORCID: 0000-0003-2022-8689 AD - Department of Pathophysiology and Allergy Research, Medical University of Vienna, Vienna, Austria. FAU - Brough, Helen A AU - Brough HA AUID- ORCID: 0000-0001-7203-0813 AD - Department of Women and Children's Health (Pediatric Allergy), School of Life Course Sciences, Faculty of Life Sciences and Medicine, King's College London, London, United Kingdom. AD - Children's Allergy Service, Evelina London, Guy's and St Thomas' Hospital, London, United Kingdom. FAU - Bublin, Merima AU - Bublin M AUID- ORCID: 0000-0002-7191-9431 AD - Department of Pathophysiology and Allergy Research, Medical University of Vienna, Vienna, Austria. FAU - Campbell, Dianne AU - Campbell D AUID- ORCID: 0000-0002-0907-6963 AD - Department of Allergy and Immunology, Children's Hospital at Westmead, Sydney Children's Hospitals Network, Sydney, New South Wales, Australia. AD - Child and Adolescent Health, Faculty of Medicine and Health, University of Sydney, Sydney, New South Wales, Australia. FAU - Caraballo, Luis AU - Caraballo L AUID- ORCID: 0000-0002-5204-1109 AD - Institute for Immunological Research, University of Cartagena, Cartagena de Indias, Colombia, Colombia. FAU - Caubet, Jean Christoph AU - Caubet JC AUID- ORCID: 0000-0001-5006-5724 AD - Pediatric Allergy Unit, Department of Child and Adolescent, University Hospitals of Geneva, Geneva, Switzerland. FAU - Celi, Giorgio AU - Celi G AD - Centro DH Allergologia e Immunologia Clinica ASST- MANTOVA (MN), Mantova, Italy. FAU - Chapman, Martin D AU - Chapman MD AUID- ORCID: 0000-0002-0845-3632 AD - InBio, Charlottesville, Virginia, USA. FAU - Chruszcz, Maksymilian AU - Chruszcz M AUID- ORCID: 0000-0001-7521-5485 AD - Department of Chemistry and Biochemistry, University of South Carolina, Columbia, South Carolina, USA. FAU - Custovic, Adnan AU - Custovic A AUID- ORCID: 0000-0001-5218-7071 AD - National Heart and Lung Institute, Imperial College London, London, UK. FAU - Czolk, Rebecca AU - Czolk R AUID- ORCID: 0000-0003-4296-3051 AD - Department of Infection and Immunity, Luxembourg Institute of Health, Esch-sur-Alzette, Luxembourg. AD - Faculty of Science, Technology and Medicine, University of Luxembourg, Esch-sur-Alzette, Luxembourg. FAU - Davies, Janet AU - Davies J AUID- ORCID: 0000-0002-6378-4119 AD - Queensland University of Technology, Centre for Immunology and Infection Control, School of Biomedical Sciences, Herston, Queensland, Australia. AD - Metro North Hospital and Health Service, Emergency Operations Centre, Herston, Queensland, Australia. FAU - Douladiris, Nikolaos AU - Douladiris N AUID- ORCID: 0000-0003-4037-4421 AD - Allergy Department, 2nd Paediatric Clinic, National and Kapodistrian University of Athens, Athens, Greece. FAU - Eberlein, Bernadette AU - Eberlein B AUID- ORCID: 0000-0003-4509-6491 AD - Department of Dermatology and Allergy Biederstein, School of Medicine, Technical University Munich, Munich, Germany. FAU - Ebisawa, Motohiro AU - Ebisawa M AUID- ORCID: 0000-0003-4117-558X AD - Clinical Research Center for Allergy and Rheumatology, National Hospital Organization, Sagamihara National Hospital, Kanagawa, Japan. FAU - Ehlers, Anna AU - Ehlers A AUID- ORCID: 0000-0001-7833-2900 AD - Chemical Biology and Drug Discovery, Utrecht University, Utrecht, The Netherlands. AD - Center for Translational Immunology, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands. AD - Department of Immunology and Dermatology/ Allergology, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands. FAU - Eigenmann, Philippe AU - Eigenmann P AUID- ORCID: 0000-0003-1738-1826 AD - Pediatric Allergy Unit, Department of Child and Adolescent, University Hospitals of Geneva, Geneva, Switzerland. FAU - Gadermaier, Gabriele AU - Gadermaier G AUID- ORCID: 0000-0002-4886-417X AD - Department of Biosciences and Medical Biology, Paris Lodron University Salzburg, Salzburg, Austria. FAU - Giovannini, Mattia AU - Giovannini M AUID- ORCID: 0000-0001-9568-6882 AD - Allergy Unit, Department of Pediatrics, Meyer Children's University Hospital, Florence, Italy. FAU - Gomez, Francisca AU - Gomez F AUID- ORCID: 0000-0003-1607-6686 AD - Allergy Unit IBIMA-Hospital Regional Universitario de Malaga, Malaga, Spain. AD - Spanish Network for Allergy research RETIC ARADyAL, Malaga, Spain. FAU - Grohman, Rebecca AU - Grohman R AD - NYU Langone Health, Department of Internal Medicine, New York, New York, USA. FAU - Guillet, Carole AU - Guillet C AUID- ORCID: 0000-0003-3809-0526 AD - Department of Dermatology, University Hospital Zurich, Zurich, Switzerland. AD - Faculty of Medicine, University of Zurich, Zurich, Switzerland. FAU - Hafner, Christine AU - Hafner C AUID- ORCID: 0000-0003-3745-1414 AD - Department of Dermatology, University Hospital St. Poelten, Karl Landsteiner University of Health Sciences, St. Poelten, Austria. FAU - Hamilton, Robert G AU - Hamilton RG AD - Johns Hopkins University School of Medicine, Baltimore, Maryland, USA. FAU - Hauser, Michael AU - Hauser M AUID- ORCID: 0000-0001-6558-755X AD - Department of Biosciences and Medical Biology, Paris Lodron University Salzburg, Salzburg, Austria. FAU - Hawranek, Thomas AU - Hawranek T AD - Department of Dermatology and Allergology, Paracelsus Private Medical University, Salzburg, Austria. FAU - Hoffmann, Hans Jurgen AU - Hoffmann HJ AUID- ORCID: 0000-0002-6743-7931 AD - Institute for Clinical Medicine, Faculty of Health, Aarhus University, Aarhus, Denmark. AD - Department of Respiratory Diseases and Allergy, Aarhus University Hospital, Aarhus, Denmark. FAU - Holzhauser, Thomas AU - Holzhauser T AUID- ORCID: 0000-0002-7818-7261 AD - Division of Allergology, Paul-Ehrlich-Institut, Langen, Germany. FAU - Iizuka, Tomona AU - Iizuka T AUID- ORCID: 0000-0002-1946-277X AD - Laboratory of Protein Science, Graduate School of Life Science, Hokkaido University, Sapporo, Japan. FAU - Jacquet, Alain AU - Jacquet A AUID- ORCID: 0000-0002-0980-9741 AD - Department of Biochemistry, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand. FAU - Jakob, Thilo AU - Jakob T AUID- ORCID: 0000-0002-3124-9998 AD - Department of Dermatology and Allergology, University Medical Center, Justus Liebig University Giessen, Giessen, Germany. FAU - Janssen-Weets, Bente AU - Janssen-Weets B AUID- ORCID: 0000-0003-3379-7792 AD - Department of Infection and Immunity, Luxembourg Institute of Health, Esch-sur-Alzette, Luxembourg. AD - Odense Research Center for Anaphylaxis, University of Southern Denmark, Odense, Denmark. FAU - Jappe, Uta AU - Jappe U AUID- ORCID: 0000-0001-5602-3672 AD - Division of Clinical and Molecular Allergology, Priority Research Area Asthma and Allergy, Research Center Borstel, Borstel, Germany. AD - Leibniz Lung Center, Airway Research Center North (ARCN), Member of the German Center for Lung Research, Germany. AD - Interdisciplinary Allergy Outpatient Clinic, Dept. of Pneumology, University of Lubeck, Lubeck, Germany. FAU - Jutel, Marek AU - Jutel M AD - Department of Clinical Immunology, Wroclaw Medical University, Wroclaw, Poland. FAU - Kalic, Tanja AU - Kalic T AUID- ORCID: 0000-0002-9641-0244 AD - Department of Pathophysiology and Allergy Research, Medical University of Vienna, Vienna, Austria. AD - Department of Dermatology, University Hospital St. Poelten, Karl Landsteiner University of Health Sciences, St. Poelten, Austria. FAU - Kamath, Sandip AU - Kamath S AUID- ORCID: 0000-0002-5956-8552 AD - Australian Institute of Tropical Health and Medicine, James Cook University, Townsville, Queensland, Australia. AD - Molecular Allergy Research Laboratory, College of Public Health, Medical and Veterinary Sciences, James Cook University, Townsville, Queensland, Australia. FAU - Kespohl, Sabine AU - Kespohl S AUID- ORCID: 0000-0001-7571-1323 AD - Institute for Prevention and Occupational Medicine of the German Social Accident Insurance, Institute of the Ruhr- Universitat Bochum, Bochum, Germany. FAU - Kleine-Tebbe, Jorg AU - Kleine-Tebbe J AD - Allergy & Asthma Center Westend, Outpatient Clinic and Clinical Research Center, Berlin, Germany. FAU - Knol, Edward AU - Knol E AUID- ORCID: 0000-0001-7368-9820 AD - Department of Immunology and Dermatology/ Allergology, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands. FAU - Knulst, Andre AU - Knulst A AUID- ORCID: 0000-0002-1056-3179 AD - Department of Immunology and Dermatology/ Allergology, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands. FAU - Konradsen, Jon R AU - Konradsen JR AUID- ORCID: 0000-0001-7745-8624 AD - Department of Women's and Children's Health, Karolinska Institutet, Stockholm, Sweden. AD - Pediatric Allergy and Pulmonology Unit at Astrid Lindgren Children's Hospital, Karolinska University Hospital, Stockholm, Sweden. FAU - Korosec, Peter AU - Korosec P AUID- ORCID: 0000-0002-0835-1599 AD - University Clinic of Respiratory and Allergic Diseases Golnik, Golnik, Slovenia. AD - Faculty of Pharmacy, University of Ljubljana, Ljubljana, Slovenia. FAU - Kuehn, Annette AU - Kuehn A AUID- ORCID: 0000-0003-0474-2135 AD - Department of Infection and Immunity, Luxembourg Institute of Health, Esch-sur-Alzette, Luxembourg. FAU - Lack, Gideon AU - Lack G AUID- ORCID: 0000-0001-7350-4021 AD - Department of Women and Children's Health (Pediatric Allergy), School of Life Course Sciences, Faculty of Life Sciences and Medicine, King's College London, London, United Kingdom. AD - Peter Gorer Department of Immunobiology, School of Immunology and Microbial Sciences, King's College London, London, United Kingdom. AD - Children's Allergy Service, Evelina London, Guy's and St Thomas' Hospital, London, United Kingdom. FAU - Le, Thuy-My AU - Le TM AUID- ORCID: 0000-0001-6571-220X AD - Center for Translational Immunology, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands. AD - Department of Immunology and Dermatology/ Allergology, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands. FAU - Lopata, Andreas AU - Lopata A AUID- ORCID: 0000-0002-2940-9235 AD - Australian Institute of Tropical Health and Medicine, James Cook University, Townsville, Queensland, Australia. AD - Molecular Allergy Research Laboratory, College of Public Health, Medical and Veterinary Sciences, James Cook University, Townsville, Queensland, Australia. FAU - Luengo, Olga AU - Luengo O AUID- ORCID: 0000-0002-8905-2776 AD - RETIC ARADyAL and RICORS Enfermedades Inflamatorias (REI), Madrid, Spain. AD - Allergy Section, Internal Medicine Department, Vall d'Hebron University Hospital, Vall d'Hebron Research Institute (VHIR), Universitat Autonoma de Barcelona, Barcelona, Spain. FAU - Makela, Mika AU - Makela M AD - Division of Allergy, Helsinki University Hospital and University of Helsinki, Helsinki, Finland. AD - Pediatric Department, Skin and Allergy Hospital, Helsinki University Central Hospital, Helsinki, Finland. FAU - Marra, Alessandro Maria AU - Marra AM AD - ASST Rhodense, Ospedale di Garbagnate Milanese, Milan, Italy. FAU - Mills, Clare AU - Mills C AUID- ORCID: 0000-0001-7433-1740 AD - Division of Infection, Immunity and Respiratory Medicine, School of Biological Sciences, Manchester Institute of Biotechnology, The University of Manchester, Manchester, UK. FAU - Morisset, Martine AU - Morisset M AUID- ORCID: 0000-0002-4028-703X AD - Allergy Unit, Angers University Hospital, Angers, France. FAU - Muraro, Antonella AU - Muraro A AUID- ORCID: 0000-0002-5026-5862 AD - Food Allergy Referral Centre, Department of Woman and Child Health, Padua University Hospital, Padua, Italy. FAU - Nowak-Wegrzyn, Anna AU - Nowak-Wegrzyn A AUID- ORCID: 0000-0002-0960-9854 AD - Division of Pediatric Allergy and Immunology, NYU Grossman School of Medicine, Hassenfeld Children's Hospital, New York, New York, USA. AD - Department of Pediatrics, Gastroenterology and Nutrition, Collegium Medicum, University of Warmia and Mazury, Olsztyn, Poland. FAU - Nugraha, Roni AU - Nugraha R AUID- ORCID: 0000-0001-5935-5867 AD - Molecular Allergy Research Laboratory, College of Public Health, Medical and Veterinary Sciences, James Cook University, Townsville, Queensland, Australia. AD - Department of Aquatic Product Technology, Faculty of Fisheries and Marine Science, IPB University, Bogor, Indonesia. FAU - Ollert, Markus AU - Ollert M AUID- ORCID: 0000-0002-8055-0103 AD - Department of Infection and Immunity, Luxembourg Institute of Health, Esch-sur-Alzette, Luxembourg. AD - Odense Research Center for Anaphylaxis, University of Southern Denmark, Odense, Denmark. FAU - Palosuo, Kati AU - Palosuo K AUID- ORCID: 0000-0002-4357-0439 AD - Department of Allergology, Helsinki University Hospital and University of Helsinki, Helsinki, Finland. FAU - Pastorello, Elide Anna AU - Pastorello EA AUID- ORCID: 0000-0002-3753-1783 AD - Centro di Allergologia, Casa di Cura Ambrosiana Cesano Boscone, Milan, Italy. FAU - Patil, Sarita Ulhas AU - Patil SU AUID- ORCID: 0000-0002-2172-2286 AD - Division of Rheumatology, Allergy and Immunology, Departments of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA. AD - Division of Allergy and Immunology, Department of Pediatrics, Massachusetts General Hospital, Boston, Massachusetts, USA. FAU - Platts-Mills, Thomas AU - Platts-Mills T AUID- ORCID: 0000-0002-1263-329X AD - Division of Allergy and Clinical Immunology, University of Virginia, Charlottesville, Virginia, USA. FAU - Pomes, Anna AU - Pomes A AUID- ORCID: 0000-0002-8729-1829 AD - InBio, Charlottesville, Virginia, USA. FAU - Poncet, Pascal AU - Poncet P AUID- ORCID: 0000-0003-0757-5424 AD - Institut Pasteur, Immunology Department, Paris, France. AD - Allergy & Environment Research Team Armand Trousseau Children Hospital, APHP, Paris, France. FAU - Potapova, Ekaterina AU - Potapova E AUID- ORCID: 0000-0003-4427-6335 AD - Department of Pediatric Respiratory Medicine, Immunology and Critical Care Medicine, Charite Universitatsmedizin Berlin, Berlin, Germany. FAU - Poulsen, Lars K AU - Poulsen LK AUID- ORCID: 0000-0002-1730-847X AD - Allergy Clinic, Department of Dermatology and Allergy, Copenhagen University Hospital-Herlev and Gentofte, Copenhagen, Denmark. FAU - Radauer, Christian AU - Radauer C AUID- ORCID: 0000-0001-9920-4449 AD - Department of Pathophysiology and Allergy Research, Medical University of Vienna, Vienna, Austria. FAU - Radulovic, Suzana AU - Radulovic S AUID- ORCID: 0000-0003-1154-8365 AD - Department of Women and Children's Health (Pediatric Allergy), School of Life Course Sciences, Faculty of Life Sciences and Medicine, King's College London, London, United Kingdom. AD - Children's Allergy Service, Evelina London, Guy's and St Thomas' Hospital, London, United Kingdom. FAU - Raulf, Monika AU - Raulf M AUID- ORCID: 0000-0001-6315-120X AD - Institute for Prevention and Occupational Medicine of the German Social Accident Insurance, Institute of the Ruhr- Universitat Bochum, Bochum, Germany. FAU - Rouge, Pierre AU - Rouge P AUID- ORCID: 0000-0002-9936-7843 AD - UMR 152 PharmaDev, IRD, Universite Paul Sabatier, Faculte de Pharmacie, Toulouse, France. FAU - Sastre, Joaquin AU - Sastre J AUID- ORCID: 0000-0003-4689-6837 AD - Allergy Service, Fundacion Jimenez Diaz; CIBER de Enfermedades Respiratorias (CIBERES); Faculty of Medicine, Universidad Autonoma de Madrid, Madrid, Spain. FAU - Sato, Sakura AU - Sato S AUID- ORCID: 0000-0003-3674-0759 AD - Allergy Department, 2nd Paediatric Clinic, National and Kapodistrian University of Athens, Athens, Greece. FAU - Scala, Enrico AU - Scala E AUID- ORCID: 0000-0002-9391-9168 AD - Clinical and Laboratory Molecular Allergy Unit - IDI- IRCCS, Fondazione L M Monti Rome, Rome, Italy. FAU - Schmid, Johannes M AU - Schmid JM AUID- ORCID: 0000-0002-4558-2943 AD - Department of Respiratory Diseases and Allergy, Aarhus University Hospital, Aarhus, Denmark. FAU - Schmid-Grendelmeier, Peter AU - Schmid-Grendelmeier P AUID- ORCID: 0000-0003-3215-3370 AD - Department of Dermatology, University Hospital Zurich, Zurich, Switzerland. AD - Christine Kuhne Center for Allergy Research and Education CK-CARE, Davos, Switzerland. FAU - Schrama, Denise AU - Schrama D AUID- ORCID: 0000-0003-0274-5957 AD - Centre of Marine Sciences (CCMAR), Universidade do Algarve, Faro, Portugal. FAU - Senechal, Helene AU - Senechal H AUID- ORCID: 0000-0002-8415-8803 AD - Allergy & Environment Research Team Armand Trousseau Children Hospital, APHP, Paris, France. FAU - Traidl-Hoffmann, Claudia AU - Traidl-Hoffmann C AUID- ORCID: 0000-0001-5085-5179 AD - Christine Kuhne Center for Allergy Research and Education CK-CARE, Davos, Switzerland. AD - Department of Environmental Medicine, Faculty of Medicine, University of Augsburg, Augsburg, Germany. FAU - Valverde-Monge, Marcela AU - Valverde-Monge M AUID- ORCID: 0000-0002-0172-3951 AD - Allergy Service, Fundacion Jimenez Diaz; CIBER de Enfermedades Respiratorias (CIBERES); Faculty of Medicine, Universidad Autonoma de Madrid, Madrid, Spain. FAU - van Hage, Marianne AU - van Hage M AUID- ORCID: 0000-0003-3091-1596 AD - Department of Medicine Solna, Division of Immunology and Allergy, Karolinska Institutet, Stockholm, Sweden. AD - Department of Clinical Immunology and Transfusion Medicine, Karolinska University Hospital, Stockholm, Sweden. FAU - van Ree, Ronald AU - van Ree R AUID- ORCID: 0000-0003-0767-0894 AD - Department of Experimental Immunology and Department of Otorhinolaryngology, Amsterdam University Medical Centers, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands. FAU - Verhoeckx, Kitty AU - Verhoeckx K AUID- ORCID: 0000-0002-6557-3198 AD - Department of Immunology and Dermatology/ Allergology, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands. FAU - Vieths, Stefan AU - Vieths S AUID- ORCID: 0000-0003-3826-6704 AD - Division of Allergology, Paul-Ehrlich-Institut, Langen, Germany. FAU - Wickman, Magnus AU - Wickman M AUID- ORCID: 0000-0003-2710-8620 AD - Department of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden. FAU - Zakzuk, Josefina AU - Zakzuk J AUID- ORCID: 0000-0002-6007-5376 AD - Institute for Immunological Research, University of Cartagena, Cartagena de Indias, Colombia, Colombia. FAU - Matricardi, Paolo M AU - Matricardi PM AUID- ORCID: 0000-0001-5485-0324 AD - Department of Pediatric Respiratory Medicine, Immunology and Critical Care Medicine, Charite Universitatsmedizin Berlin, Berlin, Germany. FAU - Hoffmann-Sommergruber, Karin AU - Hoffmann-Sommergruber K AUID- ORCID: 0000-0002-8830-058X AD - Department of Pathophysiology and Allergy Research, Medical University of Vienna, Vienna, Austria. LA - eng GR - MR/K002449/1/MRC_/Medical Research Council/United Kingdom GR - WT_/Wellcome Trust/United Kingdom GR - R01 AI077653/AI/NIAID NIH HHS/United States GR - MR/M008517/1/MRC_/Medical Research Council/United Kingdom GR - G0902018/MRC_/Medical Research Council/United Kingdom GR - MR/W028352/1/MRC_/Medical Research Council/United Kingdom GR - MR/S002359/1/MRC_/Medical Research Council/United Kingdom GR - MR/S025340/1/MRC_/Medical Research Council/United Kingdom GR - BB_/Biotechnology and Biological Sciences Research Council/United Kingdom GR - MR/T031565/1/MRC_/Medical Research Council/United Kingdom GR - MC_PC_18052/MRC_/Medical Research Council/United Kingdom GR - MR/K002449/2/MRC_/Medical Research Council/United Kingdom GR - M 3295/FWF_/Austrian Science Fund FWF/Austria GR - MR/T032081/1/MRC_/Medical Research Council/United Kingdom PT - Journal Article PT - Research Support, N.I.H., Extramural PT - Research Support, Non-U.S. Gov't PL - England TA - Pediatr Allergy Immunol JT - Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology JID - 9106718 RN - 0 (Allergens) RN - 37341-29-0 (Immunoglobulin E) SB - IM MH - Humans MH - *Hypersensitivity/diagnosis/therapy MH - Allergens MH - Immunoglobulin E OTO - NOTNLM OT - IgE OT - IgE cross-reactivity OT - allergy OT - allergy diagnosis OT - anaphylaxis OT - asthma OT - atopic dermatitis OT - basophil activation test OT - component-resolved diagnosis OT - cross-reactive carbohydrates OT - diagnostic algorithms OT - food allergy OT - gibberellin-regulated proteins OT - lipocalins OT - microarray OT - molecular allergology OT - non-specific lipid transfer proteins OT - oleosins OT - pan-allergens OT - parvalbumins OT - pathogenesis-related protein family 10 OT - polcalcins OT - pollen allergy OT - precision medicine OT - profilins OT - seed storage proteins OT - serum albumins OT - tropomyosins EDAT- 2023/05/15 19:12 MHDA- 2023/05/17 06:42 CRDT- 2023/05/15 14:23 PHST- 2022/08/29 00:00 [received] PHST- 2022/09/05 00:00 [accepted] PHST- 2023/05/17 06:42 [medline] PHST- 2023/05/15 19:12 [pubmed] PHST- 2023/05/15 14:23 [entrez] AID - 10.1111/pai.13854 [doi] PST - ppublish SO - Pediatr Allergy Immunol. 2023 Mar;34 Suppl 28:e13854. doi: 10.1111/pai.13854.