PMID- 37187268
OWN - NLM
STAT- MEDLINE
DCOM- 20230605
LR  - 20230605
IS  - 1872-7786 (Electronic)
IS  - 0009-2797 (Linking)
VI  - 380
DP  - 2023 Aug 1
TI  - Association of nanoparticles and Nrf2 with various oxidative stress-mediated 
      diseases.
PG  - 110535
LID - S0009-2797(23)00202-8 [pii]
LID - 10.1016/j.cbi.2023.110535 [doi]
AB  - Nuclear factor erythroid 2-related factor 2 (Nrf2) is a transcription factor that 
      regulates the cellular antioxidant defense system at the posttranscriptional 
      level. During oxidative stress, Nrf2 is released from its negative regulator 
      Kelch-like ECH-associated protein 1 (Keap1) and binds to antioxidant response 
      element (ARE) to transcribe antioxidative metabolizing/detoxifying genes. Various 
      transcription factors like aryl hydrocarbon receptor (AhR) and nuclear factor 
      kappa light chain enhancer of activated B cells (NF-kB) and epigenetic 
      modification including DNA methylation and histone methylation might also 
      regulate the expression of Nrf2. Despite its protective role, Keap1/Nrf2/ARE 
      signaling is considered as a pharmacological target due to its involvement in 
      various pathophysiological conditions such as diabetes, cardiovascular diseases, 
      cancers, neurodegenerative diseases, hepatotoxicity and kidney disorders. 
      Recently, nanomaterials have received a lot of attention due to their unique 
      physiochemical properties and are also used in various biological applications, 
      for example, biosensors, drug delivery systems, cancer therapy, etc. In this 
      review, we will be discussing the functions of nanoparticles and Nrf2 as a 
      combined therapy or sensitizing agent and their significance in various diseases 
      such as diabetes, cancers and oxidative stress-mediated diseases.
CI  - Copyright (c) 2023 Elsevier B.V. All rights reserved.
FAU - Thiruvengadam, Rekha
AU  - Thiruvengadam R
AD  - Department of Integrative Bioscience & Biotechnology, Sejong University, Seoul, 
      05006, Republic of Korea.
FAU - Venkidasamy, Baskar
AU  - Venkidasamy B
AD  - Department of Oral and Maxillofacial Surgery, Saveetha Dental College and 
      Hospital, Saveetha Institute of Medical and Technical Sciences, Chennai, 600077, 
      India.
FAU - Samynathan, Ramkumar
AU  - Samynathan R
AD  - Department of Oral and Maxillofacial Surgery, Saveetha Dental College and 
      Hospital, Saveetha Institute of Medical and Technical Sciences, Chennai, 600077, 
      India.
FAU - Govindasamy, Rajakumar
AU  - Govindasamy R
AD  - Department of Periodontics, Saveetha Dental College and Hospital, Saveetha 
      Institute of Medical and Technical Sciences, Chennai, 600077, India.
FAU - Thiruvengadam, Muthu
AU  - Thiruvengadam M
AD  - Department of Applied Bioscience, College of Life and Environmental Sciences, 
      Konkuk University, Seoul, 05029, Republic of Korea.
FAU - Kim, Jin Hee
AU  - Kim JH
AD  - Department of Integrative Bioscience & Biotechnology, Sejong University, Seoul, 
      05006, Republic of Korea. Electronic address: jhkim777@sejong.ac.kr.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20230513
PL  - Ireland
TA  - Chem Biol Interact
JT  - Chemico-biological interactions
JID - 0227276
RN  - 0 (Kelch-Like ECH-Associated Protein 1)
RN  - 0 (NF-E2-Related Factor 2)
RN  - 0 (Antioxidants)
SB  - IM
MH  - Humans
MH  - Kelch-Like ECH-Associated Protein 1/metabolism
MH  - NF-E2-Related Factor 2/metabolism
MH  - Oxidative Stress
MH  - Antioxidants/metabolism
MH  - *Neoplasms/drug therapy
MH  - *Nanoparticles
OTO - NOTNLM
OT  - Antioxidants
OT  - Detoxification
OT  - Nanoparticles
OT  - Nrf2
OT  - Oxidative stress
COIS- Declaration of competing interest The authors declare that they have no known 
      competing financial interests or personal relationships that could have appeared 
      to influence the work reported in this paper.
EDAT- 2023/05/16 01:09
MHDA- 2023/06/05 06:42
CRDT- 2023/05/15 19:21
PHST- 2023/02/07 00:00 [received]
PHST- 2023/04/18 00:00 [revised]
PHST- 2023/05/08 00:00 [accepted]
PHST- 2023/06/05 06:42 [medline]
PHST- 2023/05/16 01:09 [pubmed]
PHST- 2023/05/15 19:21 [entrez]
AID - S0009-2797(23)00202-8 [pii]
AID - 10.1016/j.cbi.2023.110535 [doi]
PST - ppublish
SO  - Chem Biol Interact. 2023 Aug 1;380:110535. doi: 10.1016/j.cbi.2023.110535. Epub 
      2023 May 13.