PMID- 37187663
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20230517
IS  - 2168-8184 (Print)
IS  - 2168-8184 (Electronic)
IS  - 2168-8184 (Linking)
VI  - 15
IP  - 4
DP  - 2023 Apr
TI  - Maternal Hyperhomocysteinemia as a Predictor of Placenta-Mediated Pregnancy 
      Complications: A Two-Year Novel Study.
PG  - e37461
LID - 10.7759/cureus.37461 [doi]
LID - e37461
AB  - Background Placenta-mediated pregnancy complications (PMPCs) are a significant 
      contributor to adverse maternal and fetal outcomes. Though the exact cause of the 
      array of pregnancy-related vascular disorders is still unknown, increased 
      maternal serum homocysteine (Hct) levels have been linked to the pathophysiology. 
      Hyperhomocysteinemia (HHct) has been strongly linked with the risk of developing 
      PMPCs such as preeclampsia (PE), fetal growth restriction (FGR), intrauterine 
      fetal death (IUFD), preterm births and placental abruption. Methodology The 
      present observational study was carried out on 810 low-risk antenatal women in 
      their early second trimester (13-20 weeks gestation age) in the department of 
      obstetrics and gynecology of a tertiary care rural hospital to identify the 
      significance of abnormally raised maternal serum Hct level in developing PMPCs. 
      Results Of the 810 participants studied, 224 (27.65%) had raised Hct 
      levels whereas the rest of the 586 (72.35%) participants had normal Hct levels. 
      The mean Hct level of raised homocysteine group (18.59 +/- 2.46 micromol/L) was 
      substantially raised than the normal Hct group (8.64 +/- 3.1 micromol/L). It was 
      observed that women with elevated serum Hct levels developed PMPCs significantly 
      more than women with normal serum Hct levels (p-value <0.05). Among HHct 
      subjects, 65.18% developed PE, 34.38% had FGR, 28.13% had a preterm delivery, 
      4.02% had abruptio placentae and 3.57% had IUFD. Conclusions The focus of the 
      current study is on an easy and quick intervention such as assessing the 
      often-ignored levels of Hct during pregnancy that can help predict and prevent 
      PMPCs. It also highlights the necessity for well-thought-out large-scale studies 
      and trials to further examine the phenomena, as pregnancy may be the only time 
      when rural women will have the opportunity to receive advice and to be tested for 
      HHct.
CI  - Copyright (c) 2023, Memon et al.
FAU - Memon, Sharmeen I
AU  - Memon SI
AD  - Obstetrics and Gynaecology, Jawaharlal Nehru Medical College, Datta Meghe 
      Institute of Higher Education and Research, Wardha, IND.
FAU - Acharya, Neema S
AU  - Acharya NS
AD  - Obstetrics and Gynaecology, Jawaharlal Nehru Medical College, Datta Meghe 
      Institute of Higher Education and Research, Wardha, IND.
FAU - Acharya, Sourya
AU  - Acharya S
AD  - General Medicine, Jawaharlal Nehru Medical College, Datta Meghe Institute of 
      Higher Education and Research, Wardha, IND.
FAU - Potdar, Jyotsana
AU  - Potdar J
AD  - Obstetrics and Gynaecology, Jawaharlal Nehru Medical College, Datta Meghe 
      Institute of Higher Education and Research, Wardha, IND.
FAU - Karnik, Megha
AU  - Karnik M
AD  - Obstetrics and Gynaecology, Jawaharlal Nehru Medical College, Datta Meghe 
      Institute of Higher Education and Research, Wardha, IND.
FAU - Mohammad, Shazia
AU  - Mohammad S
AD  - Obstetrics and Gynaecology, Jawaharlal Nehru Medical College, Datta Meghe 
      Institute of Higher Education and Research, Wardha, IND.
LA  - eng
PT  - Journal Article
DEP - 20230411
PL  - United States
TA  - Cureus
JT  - Cureus
JID - 101596737
PMC - PMC10175711
OTO - NOTNLM
OT  - fetal growth restriction
OT  - hyperhomocysteinemia
OT  - placenta mediated pregnancy complications
OT  - placental abruption
OT  - preeclampsia
COIS- The authors have declared that no competing interests exist.
EDAT- 2023/05/16 01:09
MHDA- 2023/05/16 01:10
PMCR- 2023/04/11
CRDT- 2023/05/15 19:29
PHST- 2023/03/07 00:00 [received]
PHST- 2023/04/11 00:00 [accepted]
PHST- 2023/05/16 01:10 [medline]
PHST- 2023/05/16 01:09 [pubmed]
PHST- 2023/05/15 19:29 [entrez]
PHST- 2023/04/11 00:00 [pmc-release]
AID - 10.7759/cureus.37461 [doi]
PST - epublish
SO  - Cureus. 2023 Apr 11;15(4):e37461. doi: 10.7759/cureus.37461. eCollection 2023 
      Apr.