PMID- 37188155
OWN - NLM
STAT- MEDLINE
DCOM- 20230517
LR  - 20230517
IS  - 1742-1241 (Electronic)
IS  - 1368-5031 (Print)
IS  - 1368-5031 (Linking)
VI  - 2023
DP  - 2023
TI  - Serum 25-Hydroxyvitamin D Levels in Type 2 Diabetes Patients in North China: 
      Seasonality and the Association between Vitamin D Status and Glycosylated 
      Hemoglobin Levels.
PG  - 4151224
LID - 10.1155/2023/4151224 [doi]
LID - 4151224
AB  - BACKGROUND AND AIMS: Previous studies have reported a correlation between vitamin 
      D levels and seasonality in healthy populations. However, there are few studies 
      on the seasonal variation in vitamin D levels and its relationship with 
      glycosylated hemoglobin (HbA1c) in patients with type 2 diabetes mellitus (T2DM). 
      The objective of this study was to investigate seasonal changes in serum 
      25-hydroxyvitamin D [25(OH)D] levels and the associations between these vitamin D 
      concentrations and HbA1c levels in T2DM patients in Hebei, China. METHODS: A 
      cross-sectional study of 1,074 individuals with T2DM was conducted from May 2018 
      to September 2021. Levels of 25(OH)D in these patients were assessed based on 
      both sex and season, and relevant clinical or laboratory variables that could 
      impact vitamin D status were also considered. RESULTS: In the T2DM patient 
      cohort, the mean blood 25(OH)D levels were 17.05 ng/mL. A total of 698 patients 
      (65.0%) had insufficient serum 25(OH)D levels. The vitamin D deficiency rates 
      were significantly higher in the winter and spring compared to the autumn (P < 
      0.05), indicating that seasonal fluctuations can have a significant impact on 
      25(OH)D levels. The levels of vitamin D inadequacy were highest in the winter 
      (74%), and females were more likely than males to be deficient (73.4% vs. 59.5%, 
      P < 0.001). In comparison to the winter and spring, both males and females showed 
      higher 25(OH)D levels in the summer (P < 0.001). HbA1c levels were 8.9% higher in 
      those with vitamin D deficiencies than in nondeficient patients (P < 0.001). 
      HbA1c and vitamin D levels were negatively correlated (r = -0.119, P < 0.001). 
      CONCLUSION: Vitamin D deficiencies are particularly prevalent among T2DM patients 
      in Hebei, China, with exceptionally high rates in the winter and spring. Female 
      T2DM patients were at an elevated risk of vitamin D deficiency, and vitamin D 
      levels were negatively correlated with HbA1c.
CI  - Copyright (c) 2023 Chang Wang et al.
FAU - Wang, Chang
AU  - Wang C
AUID- ORCID: 0000-0002-7279-2989
AD  - Department of Endocrinology, Hebei General Hospital, Shijiazhuang 050051, China.
FAU - Li, Huan
AU  - Li H
AD  - Department of Endocrinology, Hebei General Hospital, Shijiazhuang 050051, China.
AD  - Graduate School of Hebei Medical University, Shijiazhuang 050017, China.
FAU - Huo, Lijing
AU  - Huo L
AD  - Department of Clinical Laboratory, Hebei General Hospital, Shijiazhuang 050051, 
      China.
FAU - Wang, Qing
AU  - Wang Q
AUID- ORCID: 0009-0004-6293-3022
AD  - Department of Endocrinology, Hebei General Hospital, Shijiazhuang 050051, China.
AD  - Graduate School of Hebei Medical University, Shijiazhuang 050017, China.
FAU - Zhang, Tian
AU  - Zhang T
AD  - Department of Endocrinology, Hebei General Hospital, Shijiazhuang 050051, China.
FAU - He, Xiaoyu
AU  - He X
AD  - Department of Endocrinology, Hebei General Hospital, Shijiazhuang 050051, China.
FAU - Hao, Jianan
AU  - Hao J
AD  - Department of Endocrinology, Hebei General Hospital, Shijiazhuang 050051, China.
FAU - Luo, Yu
AU  - Luo Y
AD  - Department of Endocrinology, Hebei General Hospital, Shijiazhuang 050051, China.
FAU - Ren, Luping
AU  - Ren L
AUID- ORCID: 0000-0003-3662-8847
AD  - Department of Endocrinology, Hebei General Hospital, Shijiazhuang 050051, China.
LA  - eng
PT  - Journal Article
DEP - 20230505
PL  - India
TA  - Int J Clin Pract
JT  - International journal of clinical practice
JID - 9712381
RN  - A288AR3C9H (25-hydroxyvitamin D)
RN  - 0 (Glycated Hemoglobin)
RN  - 1406-16-2 (Vitamin D)
RN  - 0 (Vitamins)
SB  - IM
MH  - Male
MH  - Humans
MH  - Female
MH  - Glycated Hemoglobin
MH  - *Diabetes Mellitus, Type 2/complications/epidemiology
MH  - Cross-Sectional Studies
MH  - Vitamin D
MH  - Vitamins
MH  - *Vitamin D Deficiency/complications/epidemiology
MH  - Seasons
PMC - PMC10181903
COIS- The authors declare that they have no conflicts of interest.
EDAT- 2023/05/16 01:09
MHDA- 2023/05/17 06:42
PMCR- 2023/05/05
CRDT- 2023/05/15 19:37
PHST- 2023/01/09 00:00 [received]
PHST- 2023/03/17 00:00 [revised]
PHST- 2023/04/17 00:00 [accepted]
PHST- 2023/05/17 06:42 [medline]
PHST- 2023/05/16 01:09 [pubmed]
PHST- 2023/05/15 19:37 [entrez]
PHST- 2023/05/05 00:00 [pmc-release]
AID - 10.1155/2023/4151224 [doi]
PST - epublish
SO  - Int J Clin Pract. 2023 May 5;2023:4151224. doi: 10.1155/2023/4151224. eCollection 
      2023.