PMID- 37189084
OWN - NLM
STAT- MEDLINE
DCOM- 20230517
LR  - 20230519
IS  - 1471-2482 (Electronic)
IS  - 1471-2482 (Linking)
VI  - 23
IP  - 1
DP  - 2023 May 15
TI  - Effects of preoperative bicarbonate and lactate levels on short-term outcomes and 
      prognosis in elderly patients with colorectal cancer.
PG  - 127
LID - 10.1186/s12893-023-02039-x [doi]
LID - 127
AB  - PURPOSE: The aim of this study was to analyze the effect of preoperative 
      bicarbonate and lactate levels (LL) on the short-term outcomes and prognosis in 
      elderly (>/= 65 years) patients with colorectal cancer (CRC). METHODS: We collected 
      the information of CRC patients from Jan 2011 to Jan 2020 in a single clinical 
      center. According to the results of preoperative blood gas analysis, we divided 
      patients into the higher/lower bicarbonate group and the higher/lower lactate 
      group, and compared their baseline information, surgery-related information, 
      overall survival (OS) and disease-free survival (DFS). RESULTS: A total of 1473 
      patients were included in this study. Comparing the clinical data of the 
      higher/lower bicarbonate group and the higher/lower lactate group, the lower 
      group were older (p < 0.01), had higher rates of coronary heart disease (CHD) 
      (p = 0.025), a higher proportion of colon tumors (p < 0.01), larger tumor size 
      (p < 0.01), higher rates of open surgery (p < 0.01), more intraoperative blood 
      loss (p < 0.01), higher overall complications (p < 0.01) and 30-day deaths 
      (p < 0.01). The higher LL patients had more male patients (p < 0.01), higher body 
      mass index (BMI) (p < 0.01) and drinking rates (p = 0.049), higher rates of type 
      2 diabetes mellitus (T2DM) (p < 0.01) and lower rates of open surgery (p < 0.01). 
      In multivariate analysis, age (p < 0.01), BMI (p = 0.036), T2DM (p = 0.023), and 
      surgical methods (p < 0.01) were independent risk factors of overall 
      complications. The independent risk factors for OS included age (p < 0.01), tumor 
      site (p = 0.014), tumor stage (p < 0.01), tumor size (p = 0.036), LL (p < 0.01), 
      and overall complications (p < 0.01). The independent risk factors of DFS 
      included age (p = 0.012), tumor site (p = 0.019), tumor stage (p < 0.01), LL 
      (p < 0.01), and overall complications (p < 0.01). CONCLUSION: Preoperative LL 
      significantly affected postoperative OS and DFS of CRC patients, but bicarbonate 
      might not affect the prognosis of CRC patients. Therefore, surgeons should 
      actively focus on and adjust the LL of patients before surgery.
CI  - (c) 2023. The Author(s).
FAU - Liu, Xiao-Yu
AU  - Liu XY
AD  - Department of Gastrointestinal Surgery, the First Affiliated Hospital of 
      Chongqing Medical University, Chongqing, 400016, China.
FAU - Li, Zi-Wei
AU  - Li ZW
AD  - Department of Gastrointestinal Surgery, the First Affiliated Hospital of 
      Chongqing Medical University, Chongqing, 400016, China.
FAU - Zhang, Bin
AU  - Zhang B
AD  - Department of Gastrointestinal Surgery, the First Affiliated Hospital of 
      Chongqing Medical University, Chongqing, 400016, China.
FAU - Liu, Fei
AU  - Liu F
AD  - Department of Gastrointestinal Surgery, the First Affiliated Hospital of 
      Chongqing Medical University, Chongqing, 400016, China.
FAU - Zhang, Wei
AU  - Zhang W
AD  - Department of Gastrointestinal Surgery, the First Affiliated Hospital of 
      Chongqing Medical University, Chongqing, 400016, China.
FAU - Peng, Dong
AU  - Peng D
AD  - Department of Gastrointestinal Surgery, the First Affiliated Hospital of 
      Chongqing Medical University, Chongqing, 400016, China. carry_dong@126.com.
LA  - eng
PT  - Journal Article
DEP - 20230515
PL  - England
TA  - BMC Surg
JT  - BMC surgery
JID - 100968567
RN  - 0 (Bicarbonates)
SB  - IM
MH  - Humans
MH  - Male
MH  - Aged
MH  - Bicarbonates
MH  - *Diabetes Mellitus, Type 2
MH  - *Colorectal Neoplasms/pathology
MH  - Prognosis
MH  - Disease-Free Survival
MH  - Retrospective Studies
PMC - PMC10186757
OTO - NOTNLM
OT  - Bicarbonate
OT  - Colorectal cancer
OT  - Elderly patients
OT  - Lactate levels
OT  - Prognosis
COIS- The authors declare no conflicts of interest.
EDAT- 2023/05/16 01:09
MHDA- 2023/05/17 06:42
PMCR- 2023/05/15
CRDT- 2023/05/15 23:36
PHST- 2022/11/15 00:00 [received]
PHST- 2023/05/11 00:00 [accepted]
PHST- 2023/05/17 06:42 [medline]
PHST- 2023/05/16 01:09 [pubmed]
PHST- 2023/05/15 23:36 [entrez]
PHST- 2023/05/15 00:00 [pmc-release]
AID - 10.1186/s12893-023-02039-x [pii]
AID - 2039 [pii]
AID - 10.1186/s12893-023-02039-x [doi]
PST - epublish
SO  - BMC Surg. 2023 May 15;23(1):127. doi: 10.1186/s12893-023-02039-x.