PMID- 37189364
OWN - NLM
STAT- MEDLINE
DCOM- 20230517
LR  - 20230530
IS  - 2218-273X (Electronic)
IS  - 2218-273X (Linking)
VI  - 13
IP  - 4
DP  - 2023 Mar 29
TI  - Correlation between Blood Lipid Level and Osteoporosis in Older Adults with Type 
      2 Diabetes Mellitus-A Retrospective Study Based on Inpatients in Beijing, China.
LID - 10.3390/biom13040616 [doi]
LID - 616
AB  - OBJECTIVE: to analyze the association between blood lipid metabolism and 
      osteoporosis (OP) in older adults with type 2 diabetes mellitus (T2DM). METHODS: 
      a total of 1158 older patients with T2DM treated by the Department of 
      Endocrinology, Peking University International Hospital, were retrospectively 
      analyzed, including 541 postmenopausal women and 617 men. RESULTS: (1) Levels of 
      low-density lipoprotein cholesterol (LDL-C) were significantly higher in the OP 
      group, while levels of high-density lipoprotein cholesterol (HDL-C) were higher 
      in the non-osteoporotic group (both p < 0.05). (2) Age, parathyroid hormone 
      (PTH), total cholesterol (TC) and LDL-C were negatively linked to the patients' 
      bone mineral density (BMD) (all p < 0.05), while the body mass index (BMI), uric 
      acid (UA) level, HDL-C level and glomerular filtration rate (eGFR) were 
      positively related to their BMD (all p < 0.05). (3) In postmenopausal women, 
      after adjustment for other indexes, raised LDL-C is an independent risk factor 
      for OP (OR = 3.38, 95% CI 1.64, 6.98, p < 0.05) while raised HDL-C is protective 
      (OR = 0.49, 95% CI 0.24, 0.96, p < 0.05). However, raised HDL-C was protective 
      against OP (OR = 0.07, 95% CI 0.01, 0.53, p < 0.05). CONCLUSION: In older T2DM 
      patients, the effect of blood lipid levels is related to sex. Our study conducted 
      a detailed sex stratification. In addition to seeing the traditional risk factors 
      of OP, such as age, sex, and BMI, we comprehensively analyzed the correlation 
      between the blood glucose level, complications, and blood lipids with OP. HDL-C 
      is a protective factor for OP in both men and women, while LDL-C independently 
      predicts OP in postmenopausal women.
FAU - Zhao, Xin
AU  - Zhao X
AD  - Department of Endocrinology, Peking University International Hospital, Beijing 
      100001, China.
FAU - Sun, Jianbin
AU  - Sun J
AD  - Department of Endocrinology, Peking University International Hospital, Beijing 
      100001, China.
FAU - Xin, Sixu
AU  - Xin S
AD  - Department of Endocrinology, Peking University International Hospital, Beijing 
      100001, China.
FAU - Zhang, Xiaomei
AU  - Zhang X
AD  - Department of Endocrinology, Peking University International Hospital, Beijing 
      100001, China.
LA  - eng
PT  - Journal Article
DEP - 20230329
PL  - Switzerland
TA  - Biomolecules
JT  - Biomolecules
JID - 101596414
RN  - 0 (Cholesterol, LDL)
RN  - 0 (Lipids)
RN  - 0 (Cholesterol, HDL)
SB  - IM
MH  - Male
MH  - Humans
MH  - Female
MH  - Aged
MH  - Retrospective Studies
MH  - *Diabetes Mellitus, Type 2/complications
MH  - Cholesterol, LDL
MH  - Inpatients
MH  - Beijing/epidemiology
MH  - *Osteoporosis
MH  - Lipids
MH  - Cholesterol, HDL
PMC - PMC10136067
OTO - NOTNLM
OT  - bone mineral density
OT  - high-density lipoprotein cholesterol
OT  - low-density lipoprotein cholesterol
OT  - osteoporosis
OT  - type 2 diabetes mellitus
COIS- The authors declare no conflict of interest.
EDAT- 2023/05/16 06:42
MHDA- 2023/05/17 06:42
PMCR- 2023/03/29
CRDT- 2023/05/16 01:09
PHST- 2022/11/29 00:00 [received]
PHST- 2023/02/12 00:00 [revised]
PHST- 2023/03/23 00:00 [accepted]
PHST- 2023/05/17 06:42 [medline]
PHST- 2023/05/16 06:42 [pubmed]
PHST- 2023/05/16 01:09 [entrez]
PHST- 2023/03/29 00:00 [pmc-release]
AID - biom13040616 [pii]
AID - biomolecules-13-00616 [pii]
AID - 10.3390/biom13040616 [doi]
PST - epublish
SO  - Biomolecules. 2023 Mar 29;13(4):616. doi: 10.3390/biom13040616.