PMID- 37190213
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20230519
IS  - 2072-6694 (Print)
IS  - 2072-6694 (Electronic)
IS  - 2072-6694 (Linking)
VI  - 15
IP  - 8
DP  - 2023 Apr 13
TI  - Large B-Cell Lymphomas in the 5th Edition of the WHO-Classification of 
      Haematolymphoid Neoplasms-Updated Classification and New Concepts.
LID - 10.3390/cancers15082285 [doi]
LID - 2285
AB  - The family/class of the large B-cell lymphomas (LBCL) in the 5th edition of the 
      World Health Organization (WHO) classification of haematolymphoid tumors 
      (WHO-HAEM5) features only a few major changes as compared to the 4th edition. In 
      most entities, there are only subtle changes, many of them only representing some 
      minor modifications in diagnostic terms. Major changes have been made in the 
      diffuse large B-cell lymphomas (DLBCL)/high-grade B-cell lymphomas (HGBL) 
      associated with MYC and BCL2 and/or BCL6 rearrangements. This category now 
      consists of MYC and BCL2 rearranged cases exclusively, while the MYC/BCL6 double 
      hit lymphomas now constitute genetic subtypes of DLBCL, not otherwise specified 
      (NOS) or of HGBL, NOS. Other major changes are the conceptual merger of lymphomas 
      arising in immune-privileged sites and the description of LBCL arising in the 
      setting of immune dysregulation/deficiency. In addition, novel findings 
      concerning underlying biological mechanisms in the pathogenesis of the different 
      entities are provided.
FAU - Kurz, Katrin S
AU  - Kurz KS
AD  - Department of Clinical Pathology, Robert-Bosch-Krankenhaus, 70376 Stuttgart, 
      Germany.
FAU - Ott, Michaela
AU  - Ott M
AD  - Department of Pathology, Marienhospital, 70199 Stuttgart, Germany.
FAU - Kalmbach, Sabrina
AU  - Kalmbach S
AD  - Department of Clinical Pathology, Robert-Bosch-Krankenhaus, 70376 Stuttgart, 
      Germany.
AD  - Dr. Margarete Fischer-Bosch-Institute of Clinical Pharmacology, 70376 Stuttgart, 
      Germany.
FAU - Steinlein, Sophia
AU  - Steinlein S
AD  - Department of Clinical Pathology, Robert-Bosch-Krankenhaus, 70376 Stuttgart, 
      Germany.
AD  - Dr. Margarete Fischer-Bosch-Institute of Clinical Pharmacology, 70376 Stuttgart, 
      Germany.
FAU - Kalla, Claudia
AU  - Kalla C
AD  - Department of Clinical Pathology, Robert-Bosch-Krankenhaus, 70376 Stuttgart, 
      Germany.
AD  - Dr. Margarete Fischer-Bosch-Institute of Clinical Pharmacology, 70376 Stuttgart, 
      Germany.
FAU - Horn, Heike
AU  - Horn H
AD  - Department of Clinical Pathology, Robert-Bosch-Krankenhaus, 70376 Stuttgart, 
      Germany.
AD  - Dr. Margarete Fischer-Bosch-Institute of Clinical Pharmacology, 70376 Stuttgart, 
      Germany.
FAU - Ott, German
AU  - Ott G
AD  - Department of Clinical Pathology, Robert-Bosch-Krankenhaus, 70376 Stuttgart, 
      Germany.
FAU - Staiger, Annette M
AU  - Staiger AM
AUID- ORCID: 0000-0002-5896-3200
AD  - Department of Clinical Pathology, Robert-Bosch-Krankenhaus, 70376 Stuttgart, 
      Germany.
AD  - Dr. Margarete Fischer-Bosch-Institute of Clinical Pharmacology, 70376 Stuttgart, 
      Germany.
LA  - eng
GR  - 3.2.4./Robert-Bosch-Stiftung (project O3), Stuttgart, Germany. Project 3.2.4./
GR  - DJCLS 03 FN/2020/Forschungsstipendium der Jose Carreras Leukamie Stiftung/
PT  - Journal Article
PT  - Review
DEP - 20230413
PL  - Switzerland
TA  - Cancers (Basel)
JT  - Cancers
JID - 101526829
PMC - PMC10137297
OTO - NOTNLM
OT  - WHO-HAEM5
OT  - classification
OT  - diffuse large B-cell lymphoma
OT  - genetics
OT  - large B-cell lymphoma
COIS- The authors declare no conflict of interest.
EDAT- 2023/05/16 06:42
MHDA- 2023/05/16 06:43
PMCR- 2023/04/13
CRDT- 2023/05/16 01:13
PHST- 2023/01/31 00:00 [received]
PHST- 2023/04/05 00:00 [revised]
PHST- 2023/04/06 00:00 [accepted]
PHST- 2023/05/16 06:43 [medline]
PHST- 2023/05/16 06:42 [pubmed]
PHST- 2023/05/16 01:13 [entrez]
PHST- 2023/04/13 00:00 [pmc-release]
AID - cancers15082285 [pii]
AID - cancers-15-02285 [pii]
AID - 10.3390/cancers15082285 [doi]
PST - epublish
SO  - Cancers (Basel). 2023 Apr 13;15(8):2285. doi: 10.3390/cancers15082285.