PMID- 37190756
OWN - NLM
STAT- MEDLINE
DCOM- 20230810
LR  - 20230816
IS  - 1559-7016 (Electronic)
IS  - 0271-678X (Print)
IS  - 0271-678X (Linking)
VI  - 43
IP  - 9
DP  - 2023 Sep
TI  - The neurovascular unit in healthy and injured spinal cord.
PG  - 1437-1455
LID - 10.1177/0271678X231172008 [doi]
AB  - The neurovascular unit (NVU) reflects the close temporal and spatial link between 
      neurons and blood vessels. However, the understanding of the NVU in the spinal 
      cord is far from clear and largely based on generalized knowledge obtained from 
      the brain. Herein, we review the present knowledge of the NVU and highlight 
      candidate approaches to investigate the NVU, particularly focusing on the spinal 
      cord. Several unique features maintain the highly regulated microenvironment in 
      the NVU. Autoregulation and neurovascular coupling ensure regional blood flow 
      meets the metabolic demand according to the blood supply or local neural 
      activation. The blood-central nervous system barrier partitions the circulating 
      blood from neural parenchyma and facilitates the selective exchange of 
      substances. Furthermore, we discuss spinal cord injury (SCI) as a common injury 
      from the perspective of NVU dysfunction. Hopefully, this review will help expand 
      the understanding of the NVU in the spinal cord and inspire new insights into 
      SCI.
FAU - Zhou, Rubing
AU  - Zhou R
AD  - Department of Orthopedics, Peking University Third Hospital, Beijing, China.
AD  - Neuroscience Research Institute and Department of Neurobiology, School of Basic 
      Medical Sciences, Peking University Health Science Center, Beijing, China.
FAU - Li, Junzhao
AU  - Li J
AD  - Neuroscience Research Institute and Department of Neurobiology, School of Basic 
      Medical Sciences, Peking University Health Science Center, Beijing, China.
FAU - Wang, Ruideng
AU  - Wang R
AD  - Department of Orthopedics, Peking University Third Hospital, Beijing, China.
FAU - Chen, Zhengyang
AU  - Chen Z
AD  - Department of Orthopedics, Peking University Third Hospital, Beijing, China.
FAU - Zhou, Fang
AU  - Zhou F
AUID- ORCID: 0000-0002-7775-069X
AD  - Department of Orthopedics, Peking University Third Hospital, Beijing, China.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20230515
PL  - United States
TA  - J Cereb Blood Flow Metab
JT  - Journal of cerebral blood flow and metabolism : official journal of the 
      International Society of Cerebral Blood Flow and Metabolism
JID - 8112566
SB  - IM
MH  - Humans
MH  - *Brain/blood supply
MH  - Neurons/physiology
MH  - *Spinal Cord Injuries
MH  - Head
MH  - Blood-Brain Barrier
PMC - PMC10414016
OTO - NOTNLM
OT  - Blood-spinal cord barrier
OT  - neurovascular coupling
OT  - neurovascular unit
OT  - spinal cord
OT  - spinal cord injury
COIS- The author(s) declared no potential conflicts of interest with respect to the 
      research, authorship, and/or publication of this article.
EDAT- 2023/05/16 06:42
MHDA- 2023/08/10 06:43
PMCR- 2023/05/15
CRDT- 2023/05/16 03:41
PHST- 2023/08/10 06:43 [medline]
PHST- 2023/05/16 06:42 [pubmed]
PHST- 2023/05/16 03:41 [entrez]
PHST- 2023/05/15 00:00 [pmc-release]
AID - 10.1177_0271678X231172008 [pii]
AID - 10.1177/0271678X231172008 [doi]
PST - ppublish
SO  - J Cereb Blood Flow Metab. 2023 Sep;43(9):1437-1455. doi: 
      10.1177/0271678X231172008. Epub 2023 May 15.