PMID- 37190899 OWN - NLM STAT- MEDLINE DCOM- 20230705 LR - 20230705 IS - 1447-0756 (Electronic) IS - 1341-8076 (Linking) VI - 49 IP - 7 DP - 2023 Jul TI - Normative change with gestation in fetal intraventricular pressure difference with color M-mode Doppler echocardiography. PG - 1743-1749 LID - 10.1111/jog.15672 [doi] AB - AIM: The intraventricular pressure difference (IVPD) is the pressure difference in early diastole from the base to the apex of the ventricle. It is a useful marker for evaluating diastolic function because of its role as a suction force. This study investigated the changes in total and segmental IVPDs in normal fetuses throughout gestation to obtain normative data equations. METHODS: One hundred thirty-seven healthy pregnant women at 12-40 weeks of gestation were prospectively enrolled to evaluate IVPD. The color M mode was performed, and the image was evaluated using our own code to calculate the IVPD. Segmental IVPD was divided into mid to apex and base. Pearson's correlation coefficient was used to evaluate this relationship. RESULTS: There was a significant, positive relationship between IVPD and gestational age in both ventricles (right ventricle [RV]: r = 0.800, left ventricle [LV]: r = 0.818). As for segmental IVPD, basal and mid-apical IVPD also increased with gestation in both ventricles (RV: basal, r = 0.627; mid-apical, r = 0.705; LV: basal r = 0.758; mid-apical, r = 0.756). IVPG, which was calculated as IVPD/ventricular length, also showed a weak, positive relationship with gestation in both ventricles (RV r = 0.351, p < 0.001; LV r = 0.373, p < 0.001). CONCLUSION: The total and segmental IVPDs significantly increased linearly through time. CI - (c) 2023 Japan Society of Obstetrics and Gynecology. FAU - Yamamoto, Yuka AU - Yamamoto Y AUID- ORCID: 0000-0001-8991-4551 AD - Department of Obstetrics and Gynecology, Juntendo University Faculty of Medicine, Tokyo, Japan. FAU - Takahashi, Ken AU - Takahashi K AD - Department of Pediatrics, Juntendo University Urayasu Hospital, Chiba, Japan. FAU - Takamizu, Ai AU - Takamizu A AD - Department Obstetrics and Gynecology, Juntendo University Urayasu Hospital, Chiba, Japan. FAU - Ogawa, Takahisa AU - Ogawa T AD - Department of Global Health Promotion, Tokyo Medical and Dental University Graduate School of Medicine, Tokyo, Japan. FAU - Yoshida, Koyo AU - Yoshida K AD - Department Obstetrics and Gynecology, Juntendo University Urayasu Hospital, Chiba, Japan. FAU - Itakura, Atsuo AU - Itakura A AUID- ORCID: 0000-0002-4554-164X AD - Department of Obstetrics and Gynecology, Juntendo University Faculty of Medicine, Tokyo, Japan. LA - eng PT - Journal Article DEP - 20230515 PL - Australia TA - J Obstet Gynaecol Res JT - The journal of obstetrics and gynaecology research JID - 9612761 SB - IM MH - Humans MH - Female MH - Pregnancy MH - Ventricular Pressure MH - *Heart Ventricles/diagnostic imaging MH - *Echocardiography, Doppler, Color/methods MH - Fetus MH - Echocardiography OTO - NOTNLM OT - Doppler OT - IVPD OT - diastolic function OT - fetal cardiac function OT - z-score EDAT- 2023/05/16 06:42 MHDA- 2023/07/05 06:42 CRDT- 2023/05/16 03:49 PHST- 2022/11/25 00:00 [received] PHST- 2023/04/28 00:00 [accepted] PHST- 2023/07/05 06:42 [medline] PHST- 2023/05/16 06:42 [pubmed] PHST- 2023/05/16 03:49 [entrez] AID - 10.1111/jog.15672 [doi] PST - ppublish SO - J Obstet Gynaecol Res. 2023 Jul;49(7):1743-1749. doi: 10.1111/jog.15672. Epub 2023 May 15.