PMID- 37191270
OWN - NLM
STAT- MEDLINE
DCOM- 20230626
LR  - 20230701
IS  - 1751-875X (Electronic)
IS  - 1751-8741 (Print)
IS  - 1751-8741 (Linking)
VI  - 17
IP  - 4
DP  - 2023 Jun
TI  - Osteogenesis promotion by injectable methacryloylated gelatin containing psoralen 
      and its bacteriostatic properties.
PG  - 376-386
LID - 10.1049/nbt2.12136 [doi]
AB  - The treatment of periodontitis focuses on controlling the progression of 
      inflammation, reducing plaque accumulation, and promoting bone tissue 
      reconstruction. Among them, the reconstruction of irregular bone resorption 
      caused by periodontitis is a long-standing challenge. At present, the local drug 
      treatment of periodontitis is mainly anti-inflammatory and antibacterial drugs. 
      In this study, psoralen (Pso), a Chinese herbal medicine with anti-inflammatory, 
      antibacterial, and osteogenic effects, was selected for the local treatment of 
      periodontitis. Meanwhile, an injectable methacrylate gelatin (GelMA) platform 
      loading with Pso was constructed. Pso-GelMA had the properties of fluidity, light 
      cohesion, self-healing, and slow release, which could be better used in the deep 
      and narrow structure of the periodontal pocket, and greatly increased the 
      effectiveness of local drug delivery. The pore size of Gelma hydrogel did not 
      change after loading Pso by SEM. In vitro, Pso-GelMA effectively upregulated the 
      expression of osteogenic genes and proteins, increased alkaline phosphatase 
      activity, promoted the mineralisation of rat bone marrow mesenchymal stem cells 
      (BMSCs) extracellular matrix, and had significant antibacterial effects on 
      Staphylococcus aureus and Fusobacterium nucleatum. Therefore, Pso-GelMA has 
      immense promise in the adjuvant treatment of periodontitis.
CI  - (c) 2023 The Authors. IET Nanobiotechnology published by John Wiley & Sons Ltd.
FAU - Zhang, Qi
AU  - Zhang Q
AUID- ORCID: 0000-0002-5661-9545
AD  - School of Stomatology, Qingdao University, Qingdao, China.
FAU - Chu, Fuhang
AU  - Chu F
AD  - Qingdao Stomatological Hospital Affiliated to Qingdao University, Qingdao, China.
FAU - Xu, Yingjie
AU  - Xu Y
AD  - Qingdao Stomatological Hospital Affiliated to Qingdao University, Qingdao, China.
FAU - Wu, Xiaonan
AU  - Wu X
AD  - Qingdao Stomatological Hospital Affiliated to Qingdao University, Qingdao, China.
FAU - Yu, Jie
AU  - Yu J
AD  - School of Stomatology, Qingdao University, Qingdao, China.
FAU - Cong, Beibei
AU  - Cong B
AD  - Qingdao Stomatological Hospital Affiliated to Qingdao University, Qingdao, China.
FAU - Wu, Yingtao
AU  - Wu Y
AD  - Qingdao Stomatological Hospital Affiliated to Qingdao University, Qingdao, China.
LA  - eng
GR  - 2021Z030/Shandong Province Chinese Medicine Science and Technology Project/
GR  - 2022-2024/Qingdao Key Health Discipline Development Fund/
GR  - 22-3-7-1czx-7-nsh/Qingdao Clinical Research Center for Oral Diseases/
GR  - 2022-zyym26/Qingdao Chinese Medicine Science and Technology Project/
PT  - Journal Article
DEP - 20230516
PL  - England
TA  - IET Nanobiotechnol
JT  - IET nanobiotechnology
JID - 101303205
RN  - KTZ7ZCN2EX (Ficusin)
RN  - 9000-70-8 (Gelatin)
RN  - 0 (Hydrogels)
RN  - 0 (Anti-Bacterial Agents)
RN  - 0 (Anti-Inflammatory Agents)
SB  - IM
MH  - Rats
MH  - Animals
MH  - *Osteogenesis
MH  - Ficusin/pharmacology
MH  - Gelatin/chemistry
MH  - Hydrogels/chemistry
MH  - *Periodontitis
MH  - Anti-Bacterial Agents/pharmacology
MH  - Anti-Inflammatory Agents/pharmacology
PMC - PMC10288355
OTO - NOTNLM
OT  - antibacterial activity
OT  - biomedical materials
OT  - dentistry
OT  - drugs
OT  - hydrogels
COIS- The authors declare that there is no conflict of interest that could be perceived 
      as prejudicing the impartiality of the research reported.
EDAT- 2023/05/16 13:09
MHDA- 2023/06/26 06:42
PMCR- 2023/05/16
CRDT- 2023/05/16 07:43
PHST- 2023/04/20 00:00 [revised]
PHST- 2023/01/29 00:00 [received]
PHST- 2023/04/21 00:00 [accepted]
PHST- 2023/06/26 06:42 [medline]
PHST- 2023/05/16 13:09 [pubmed]
PHST- 2023/05/16 07:43 [entrez]
PHST- 2023/05/16 00:00 [pmc-release]
AID - NBT212136 [pii]
AID - 10.1049/nbt2.12136 [doi]
PST - ppublish
SO  - IET Nanobiotechnol. 2023 Jun;17(4):376-386. doi: 10.1049/nbt2.12136. Epub 2023 
      May 16.