PMID- 37191997
OWN - NLM
STAT- MEDLINE
DCOM- 20230602
LR  - 20230602
IS  - 1944-8252 (Electronic)
IS  - 1944-8244 (Linking)
VI  - 15
IP  - 21
DP  - 2023 May 31
TI  - A Novel Hexokinases Inhibitor Based on Molecularly Imprinted Polymer for Combined 
      Starvation and Enhanced Photothermal Therapy of Malignant Tumors.
PG  - 25898-25908
LID - 10.1021/acsami.3c00079 [doi]
AB  - The heat tolerance of tumor cells induced by heat shock proteins (HSPs) is the 
      major factor that seriously hinders further application of PTT, as it can lead to 
      tumor inflammation, invasion, and even recurrence. Therefore, new strategies to 
      inhibit HSPs expression are essential to improve the antitumor efficacy of PTT. 
      Here, we prepared a novel nanoparticle inhibitor by synthesizing molecularly 
      imprinted polymers with a high imprinting factor (3.1) on the Prussian Blue 
      surface (PB@MIP) for combined tumor starvation and photothermal therapy. Owing to 
      using hexokinase (HK) epitopes as the template, the imprinted polymers could 
      inhibit the catalytic activity of HK to interfere with glucose metabolism by 
      specifically recognizing its active sites and then achieve starvation therapy by 
      restricting ATP supply. Meanwhile, MIP-mediated starvation downregulated the 
      ATP-dependent expression of HSPs and then sensitized tumors to hyperthermia, 
      ultimately improving the therapeutic effect of PTT. As the inhibitory effect of 
      PB@MIP on HK activity, more than 99% of the mice tumors were eliminated by 
      starvation therapy and enhanced PTT.
FAU - Zhuang, Ji
AU  - Zhuang J
AD  - State Key Laboratory of Medicinal Chemical Biology, Tianjin Key Laboratory of 
      Biosensing and Molecular Recognition, Research Center for Analytical Sciences, 
      College of Chemistry, Nankai University, Tianjin 300071, China.
FAU - Qin, Ya-Ting
AU  - Qin YT
AD  - ZJU-Hangzhou Global Scientific and Technological Innovation Center, Zhejiang 
      University, Hangzhou 311200, China.
FAU - Feng, Yu-Sheng
AU  - Feng YS
AD  - State Key Laboratory of Medicinal Chemical Biology, Tianjin Key Laboratory of 
      Biosensing and Molecular Recognition, Research Center for Analytical Sciences, 
      College of Chemistry, Nankai University, Tianjin 300071, China.
FAU - Su, Zheng-Chen
AU  - Su ZC
AD  - State Key Laboratory of Medicinal Chemical Biology, Tianjin Key Laboratory of 
      Biosensing and Molecular Recognition, Research Center for Analytical Sciences, 
      College of Chemistry, Nankai University, Tianjin 300071, China.
FAU - He, Xi-Wen
AU  - He XW
AD  - State Key Laboratory of Medicinal Chemical Biology, Tianjin Key Laboratory of 
      Biosensing and Molecular Recognition, Research Center for Analytical Sciences, 
      College of Chemistry, Nankai University, Tianjin 300071, China.
FAU - Li, Wen-You
AU  - Li WY
AUID- ORCID: 0000-0001-7445-9007
AD  - State Key Laboratory of Medicinal Chemical Biology, Tianjin Key Laboratory of 
      Biosensing and Molecular Recognition, Research Center for Analytical Sciences, 
      College of Chemistry, Nankai University, Tianjin 300071, China.
FAU - Zhang, Yu-Kui
AU  - Zhang YK
AD  - State Key Laboratory of Medicinal Chemical Biology, Tianjin Key Laboratory of 
      Biosensing and Molecular Recognition, Research Center for Analytical Sciences, 
      College of Chemistry, Nankai University, Tianjin 300071, China.
AD  - National Chromatographic Research and Analysis Center, Dalian Institute of 
      Chemical Physics, Chinese Academy of Sciences, Dalian 116023, China.
LA  - eng
PT  - Journal Article
DEP - 20230516
PL  - United States
TA  - ACS Appl Mater Interfaces
JT  - ACS applied materials & interfaces
JID - 101504991
RN  - 0 (Molecularly Imprinted Polymers)
RN  - EC 2.7.1.1 (Hexokinase)
RN  - 8L70Q75FXE (Adenosine Triphosphate)
SB  - IM
MH  - Animals
MH  - Mice
MH  - Molecularly Imprinted Polymers
MH  - Photothermal Therapy
MH  - Hexokinase
MH  - *Hyperthermia, Induced
MH  - *Neoplasms/drug therapy
MH  - *Nanoparticles/chemistry
MH  - Adenosine Triphosphate
MH  - *Molecular Imprinting
OTO - NOTNLM
OT  - Prussian Blue
OT  - enzyme inhibitor
OT  - molecular imprinted polymer
OT  - photothermal therapy
OT  - tumor starvation
EDAT- 2023/05/16 13:09
MHDA- 2023/06/02 06:42
CRDT- 2023/05/16 12:03
PHST- 2023/06/02 06:42 [medline]
PHST- 2023/05/16 13:09 [pubmed]
PHST- 2023/05/16 12:03 [entrez]
AID - 10.1021/acsami.3c00079 [doi]
PST - ppublish
SO  - ACS Appl Mater Interfaces. 2023 May 31;15(21):25898-25908. doi: 
      10.1021/acsami.3c00079. Epub 2023 May 16.