PMID- 37192551 OWN - NLM STAT- MEDLINE DCOM- 20230616 LR - 20230616 IS - 1878-1705 (Electronic) IS - 1567-5769 (Linking) VI - 120 DP - 2023 Jul TI - Maresin1: A multifunctional regulator in inflammatory bone diseases. PG - 110308 LID - S1567-5769(23)00631-8 [pii] LID - 10.1016/j.intimp.2023.110308 [doi] AB - Inflammation plays a crucial role in the physical response to danger signals, the elimination of toxic stimuli, and the restoration of homeostasis. However, dysregulated inflammatory responses lead to tissue damage, and chronic inflammation can disrupt osteogenic-osteoclastic homeostasis, ultimately leading to bone loss. Maresin1 (MaR1), a member of the specialized pro-resolving mediators (SPMs) family, has been found to possess significant anti-inflammatory, anti-allergic, pro-hemolytic, pro-healing, and pain-relieving properties. MaR1 is synthesized by macrophages (Mphis) and omega-3 fatty acids, and it may have the potential to promote bone homeostasis and treat inflammatory bone diseases. MaR1 has been found to stimulate osteoblast proliferation through leucine-rich repeat G protein-coupled receptor 6 (LGR6). It also activates Mphi phagocytosis and M2-type polarization, which helps to control the immune system. MaR1 can regulate T cells to exert anti-inflammatory effects and inhibit neutrophil infiltration and recruitment. In addition, MaR1 is involved in antioxidant signaling, including nuclear factor erythroid 2-related factor 2 (NRF2). It has also been found to promote the autophagic behavior of periodontal ligament stem cells, stimulate Mphis against pathogenic bacteria, and regulate tissue regeneration and repair. In summary, this review provides new information and a comprehensive overview of the critical roles of MaR1 in inflammatory bone diseases, indicating its potential as a therapeutic approach for managing skeletal metabolism and inflammatory bone diseases. CI - Copyright (c) 2023. Published by Elsevier B.V. FAU - Zhang, Zhanwei AU - Zhang Z AD - Department of Implantology, School and Hospital of Stomatology, Cheeloo College of Medicine, Shandong University, Jinan, China; Shandong Key Laboratory of Oral Tissue Regeneration, Jinan, China; Shandong Engineering Laboratory for Dental Materials and Oral Tissue Regeneration, Jinan, China; Shandong Provincial Clinical Research Center for Oral Diseases, Jinan, China. FAU - Ji, Chonghao AU - Ji C AD - Department of Implantology, School and Hospital of Stomatology, Cheeloo College of Medicine, Shandong University, Jinan, China; Shandong Key Laboratory of Oral Tissue Regeneration, Jinan, China; Shandong Engineering Laboratory for Dental Materials and Oral Tissue Regeneration, Jinan, China; Shandong Provincial Clinical Research Center for Oral Diseases, Jinan, China. FAU - Wang, Daobin AU - Wang D AD - Taian Municipal Hospital, Tai'an, China. FAU - Wang, Maoshan AU - Wang M AD - Department of Implantology, School and Hospital of Stomatology, Cheeloo College of Medicine, Shandong University, Jinan, China; Shandong Key Laboratory of Oral Tissue Regeneration, Jinan, China; Shandong Engineering Laboratory for Dental Materials and Oral Tissue Regeneration, Jinan, China; Shandong Provincial Clinical Research Center for Oral Diseases, Jinan, China. FAU - She, Xiao AU - She X AD - Department of Implantology, School and Hospital of Stomatology, Cheeloo College of Medicine, Shandong University, Jinan, China; Shandong Key Laboratory of Oral Tissue Regeneration, Jinan, China; Shandong Engineering Laboratory for Dental Materials and Oral Tissue Regeneration, Jinan, China; Shandong Provincial Clinical Research Center for Oral Diseases, Jinan, China. FAU - Song, Dawei AU - Song D AD - School of Stomatology, Shandong First Medical University & Shandong Academy of Medical Sciences, Jinan, China. FAU - Xu, Xin AU - Xu X AD - Department of Implantology, School and Hospital of Stomatology, Cheeloo College of Medicine, Shandong University, Jinan, China; Shandong Key Laboratory of Oral Tissue Regeneration, Jinan, China; Shandong Engineering Laboratory for Dental Materials and Oral Tissue Regeneration, Jinan, China; Shandong Provincial Clinical Research Center for Oral Diseases, Jinan, China. Electronic address: xinxu@sdu.edu.cn. FAU - Zhang, Dongjiao AU - Zhang D AD - Department of Implantology, School and Hospital of Stomatology, Cheeloo College of Medicine, Shandong University, Jinan, China; Shandong Key Laboratory of Oral Tissue Regeneration, Jinan, China; Shandong Engineering Laboratory for Dental Materials and Oral Tissue Regeneration, Jinan, China; Shandong Provincial Clinical Research Center for Oral Diseases, Jinan, China. Electronic address: djzhang1109@163.com. LA - eng PT - Journal Article PT - Review DEP - 20230514 PL - Netherlands TA - Int Immunopharmacol JT - International immunopharmacology JID - 100965259 RN - 0 (Anti-Inflammatory Agents) RN - 25167-62-8 (Docosahexaenoic Acids) SB - IM MH - Humans MH - *Inflammation/drug therapy MH - Macrophages MH - Phagocytosis MH - Anti-Inflammatory Agents/pharmacology MH - *Bone Diseases/drug therapy MH - Docosahexaenoic Acids/pharmacology/therapeutic use/metabolism OTO - NOTNLM OT - Bone OT - Inflammation OT - Maresin1 OT - Omega-3 fatty acid OT - Specialized pro-resolving mediators COIS- Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. EDAT- 2023/05/16 19:10 MHDA- 2023/06/16 06:42 CRDT- 2023/05/16 17:59 PHST- 2023/03/19 00:00 [received] PHST- 2023/04/26 00:00 [revised] PHST- 2023/05/05 00:00 [accepted] PHST- 2023/06/16 06:42 [medline] PHST- 2023/05/16 19:10 [pubmed] PHST- 2023/05/16 17:59 [entrez] AID - S1567-5769(23)00631-8 [pii] AID - 10.1016/j.intimp.2023.110308 [doi] PST - ppublish SO - Int Immunopharmacol. 2023 Jul;120:110308. doi: 10.1016/j.intimp.2023.110308. Epub 2023 May 14.