PMID- 37195150
OWN - NLM
STAT- Publisher
LR  - 20231003
IS  - 1437-4331 (Electronic)
IS  - 1434-6621 (Linking)
VI  - 61
IP  - 11
DP  - 2023 Oct 26
TI  - Serum GFAP - pediatric reference interval in a cohort of Danish children.
PG  - 2041-2045
LID - 10.1515/cclm-2023-0280 [doi]
AB  - OBJECTIVES: Glial fibrillary acidic protein (GFAP) in blood is an emerging 
      biomarker of brain injury and neurological disease. Its clinical use in children 
      is limited by the lack of a reference interval (RI). Thus, the aim of the present 
      study was to establish an age-dependent continuous RI for serum GFAP in children. 
      METHODS: Excess serum from routine allergy testing of 391 children, 0.4-17.9 
      years of age, was measured by a single-molecule array (Simoa) assay. A continuous 
      RI was modelled using non-parametric quantile regression and presented both 
      graphically and tabulated as discrete one-year RIs based on point estimates from 
      the model. RESULTS: Serum GFAP showed a strong age-dependency with declining 
      levels and variability from infants to adolescents. The estimated median level 
      decreased 66 % from four months to five years of age and another 65 % from five 
      years to 17.9 years of age. No gender difference was observed. CONCLUSIONS: The 
      study establishes an age-dependent RI for serum GFAP in children showing high 
      levels and variability in the first years of life.
CI  - (c) 2023 Walter de Gruyter GmbH, Berlin/Boston.
FAU - Tybirk, Lea
AU  - Tybirk L
AUID- ORCID: 0000-0003-4642-3079
AD  - Department of Clinical Biochemistry, Aarhus University Hospital, Aarhus, Denmark.
FAU - Hviid, Claus Vinter Bodker
AU  - Hviid CVB
AD  - Department of Clinical Biochemistry, Aarhus University Hospital, Aarhus, Denmark.
AD  - Department of Clinical Biochemistry, Aalborg University Hospital, Aalborg, 
      Denmark.
AD  - Department of Clinical Medicine, Aarhus University, Aarhus, Denmark.
AD  - Department of Clinical Medicine, Aalborg University, Aalborg, Denmark.
FAU - Knudsen, Cindy Soendersoe
AU  - Knudsen CS
AD  - Department of Clinical Biochemistry, Aarhus University Hospital, Aarhus, Denmark.
FAU - Parkner, Tina
AU  - Parkner T
AD  - Department of Clinical Biochemistry, Aarhus University Hospital, Aarhus, Denmark.
AD  - Department of Clinical Medicine, Aarhus University, Aarhus, Denmark.
LA  - eng
PT  - Journal Article
DEP - 20230518
PL  - Germany
TA  - Clin Chem Lab Med
JT  - Clinical chemistry and laboratory medicine
JID - 9806306
SB  - IM
OTO - NOTNLM
OT  - children
OT  - glial fibrillary acidic protein (GFAP)
OT  - reference interval
OT  - serum
EDAT- 2023/05/17 13:10
MHDA- 2023/05/17 13:10
CRDT- 2023/05/17 09:54
PHST- 2023/03/17 00:00 [received]
PHST- 2023/05/09 00:00 [accepted]
PHST- 2023/05/17 13:10 [pubmed]
PHST- 2023/05/17 13:10 [medline]
PHST- 2023/05/17 09:54 [entrez]
AID - cclm-2023-0280 [pii]
AID - 10.1515/cclm-2023-0280 [doi]
PST - epublish
SO  - Clin Chem Lab Med. 2023 May 18;61(11):2041-2045. doi: 10.1515/cclm-2023-0280. 
      Print 2023 Oct 26.