PMID- 37196041
OWN - NLM
STAT- MEDLINE
DCOM- 20230608
LR  - 20230919
IS  - 1751-7176 (Electronic)
IS  - 1524-6175 (Print)
IS  - 1524-6175 (Linking)
VI  - 25
IP  - 6
DP  - 2023 Jun
TI  - Deficiency of Tregs in hypertension-associated left ventricular hypertrophy.
PG  - 562-572
LID - 10.1111/jch.14660 [doi]
AB  - Left ventricular hypertrophy (LVH) is the most common target organ damage in 
      hypertension. Abnormal numbers or functions of CD4(+) CD25(+) Foxp3(+) regulatory 
      T lymphocytes (Tregs) can cause immune disorders, which participates in LVH. This 
      study aimed to explore the role of Tregs in LVH by investigating circulating 
      Tregs and associated cytokine levels in hypertensive patients with or without 
      LVH. Blood samples were collected from 83 hypertensive patients without LVH 
      (essential hypertension group, EH), 91 hypertensive patients with LVH (left 
      ventricular hypertrophy group, LVH), and 69 normotensive controls without LVH 
      (control group, CG). Tregs and cytokines were measured by flow cytometry and 
      enzyme-linked immunosorbent assays. We found that circulating Tregs were 
      significantly lower in hypertensive patients than in CG subjects. It was lower in 
      LVH than in EH patients. No correlation between blood pressure regulation and 
      Tregs was found in EH or LVH patients. Furthermore, Tregs in older females were 
      lower than those in older males among LVH patients. Additionally, serum 
      interleukin-10 (IL-10) and transforming growth factor beta 1 (TGFbeta1) decreased in 
      hypertensive patients, and interleukin-6 (IL-6) increased in LVH patients. Tregs 
      were negatively correlated with creatine kinase, low-density lipoprotein 
      cholesterol, apoprotein B, high-sensitivity C-reactive protein, and left 
      ventricular mass index (LVMI) values. In general, our study demonstrates 
      significantly decreased circulating Tregs in hypertensive LVH patients. Decreased 
      circulating Tregs in LVH is independent of blood pressure regulation. IL-6, 
      IL-10, and TGF-beta1 are related with LVH in hypertension.
CI  - (c) 2023 The Authors. The Journal of Clinical Hypertension published by Wiley 
      Periodicals LLC.
FAU - Tang, Ying
AU  - Tang Y
AD  - Department of Internal Cardiovascular Medicine, Second Xiangya Hospital, Central 
      South University, Changsha, Hunan, China.
FAU - Shen, Li
AU  - Shen L
AD  - Department of Internal Cardiovascular Medicine, Second Xiangya Hospital, Central 
      South University, Changsha, Hunan, China.
FAU - Bao, Jing-Hui
AU  - Bao JH
AD  - Department of Internal Cardiovascular Medicine, Second Xiangya Hospital, Central 
      South University, Changsha, Hunan, China.
FAU - Xu, Dan-Yan
AU  - Xu DY
AUID- ORCID: 0000-0003-2113-0800
AD  - Department of Internal Cardiovascular Medicine, Second Xiangya Hospital, Central 
      South University, Changsha, Hunan, China.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20230517
PL  - United States
TA  - J Clin Hypertens (Greenwich)
JT  - Journal of clinical hypertension (Greenwich, Conn.)
JID - 100888554
RN  - 130068-27-8 (Interleukin-10)
RN  - 0 (Interleukin-6)
RN  - 0 (Cytokines)
SB  - IM
MH  - Male
MH  - Female
MH  - Humans
MH  - Aged
MH  - *Hypertension
MH  - Hypertrophy, Left Ventricular
MH  - Interleukin-10
MH  - Interleukin-6
MH  - Blood Pressure
MH  - Cytokines
PMC - PMC10246464
OTO - NOTNLM
OT  - IL-10
OT  - IL-6
OT  - TGF-beta1
OT  - Tregs
OT  - hypertension
OT  - left ventricular hypertrophy
COIS- The authors declare no conflicts of interest.
EDAT- 2023/05/17 19:13
MHDA- 2023/06/08 06:42
PMCR- 2023/05/17
CRDT- 2023/05/17 13:45
PHST- 2023/04/04 00:00 [revised]
PHST- 2023/01/08 00:00 [received]
PHST- 2023/04/05 00:00 [accepted]
PHST- 2023/06/08 06:42 [medline]
PHST- 2023/05/17 19:13 [pubmed]
PHST- 2023/05/17 13:45 [entrez]
PHST- 2023/05/17 00:00 [pmc-release]
AID - JCH14660 [pii]
AID - 10.1111/jch.14660 [doi]
PST - ppublish
SO  - J Clin Hypertens (Greenwich). 2023 Jun;25(6):562-572. doi: 10.1111/jch.14660. 
      Epub 2023 May 17.