PMID- 37196470
OWN - NLM
STAT- MEDLINE
DCOM- 20230525
LR  - 20230525
IS  - 1618-0631 (Electronic)
IS  - 0344-0338 (Linking)
VI  - 246
DP  - 2023 Jun
TI  - The interplay of signaling pathways and miRNAs in the pathogenesis and targeted 
      therapy of esophageal cancer.
PG  - 154529
LID - S0344-0338(23)00229-7 [pii]
LID - 10.1016/j.prp.2023.154529 [doi]
AB  - Globally, esophageal cancer (EC) is the 6th leading cause of cancer-related 
      deaths and the second deadliest gastrointestinal cancer. Multiple genetic and 
      epigenetic factors, such as microRNAs (miRNAs), influence its onset and 
      progression. miRNAs are short nucleic acid molecules that can regulate multiple 
      cellular processes by regulating gene expression. Therefore, EC initiation, 
      progression, apoptosis evasions, invasion capacity, promotion, angiogenesis, and 
      epithelial-mesenchymal transition (EMT) enhancement are associated with miRNA 
      expression dysregulation. Wnt/-catenin signaling, Mammalian target of rapamycin 
      (mTOR)/P-gp, phosphoinositide-3-kinase (PI3K)/AKT/c-Myc, epidermal growth factor 
      receptor (EGFR), and transforming growth factor (TGF)-beta signaling are crucial 
      pathways in EC that are controlled by miRNAs. This review was conducted to 
      provide an up-to-date assessment of the role of microRNAs in EC pathogenesis and 
      their modulatory effects on responses to various EC treatment modalities.
CI  - Copyright (c) 2023 Elsevier GmbH. All rights reserved.
FAU - Doghish, Ahmed S
AU  - Doghish AS
AD  - Department of Biochemistry, Faculty of Pharmacy, Badr University in Cairo (BUC), 
      Badr City, Cairo 11829, Egypt; Biochemistry and Molecular Biology Department, 
      Faculty of Pharmacy (Boys), Al-Azhar University, Nasr City 11231, Cairo, Egypt. 
      Electronic address: ahmed_doghish@azhar.edu.eg.
FAU - El-Husseiny, Ahmed A
AU  - El-Husseiny AA
AD  - Biochemistry and Molecular Biology Department, Faculty of Pharmacy (Boys), 
      Al-Azhar University, Nasr City 11231, Cairo, Egypt; Department of Biochemistry, 
      Faculty of Pharmacy, Egyptian Russian University, Badr City 11829, Cairo, Egypt.
FAU - Abdelmaksoud, Nourhan M
AU  - Abdelmaksoud NM
AD  - Department of Biochemistry and Biotechnology, Faculty of Pharmacy, Heliopolis 
      University, Cairo 11785, Egypt.
FAU - El-Mahdy, Hesham A
AU  - El-Mahdy HA
AD  - Biochemistry and Molecular Biology Department, Faculty of Pharmacy (Boys), 
      Al-Azhar University, Nasr City 11231, Cairo, Egypt. Electronic address: 
      heshamabbas@azhar.edu.eg.
FAU - Elsakka, Elsayed G E
AU  - Elsakka EGE
AD  - Biochemistry and Molecular Biology Department, Faculty of Pharmacy (Boys), 
      Al-Azhar University, Nasr City 11231, Cairo, Egypt.
FAU - Abdel Mageed, Sherif S
AU  - Abdel Mageed SS
AD  - Pharmacology and Toxicology Department, Faculty of Pharmacy, Badr University in 
      Cairo (BUC), Badr City, Cairo 11829, Egypt.
FAU - Mahmoud, Abdulla M A
AU  - Mahmoud AMA
AD  - Pharmacology and Toxicology Department, Faculty of Pharmacy, Badr University in 
      Cairo (BUC), Badr City, Cairo 11829, Egypt.
FAU - Raouf, Ahmed Amr
AU  - Raouf AA
AD  - Pharmacology and Toxicology Department, Faculty of Pharmacy, Badr University in 
      Cairo (BUC), Badr City, Cairo 11829, Egypt.
FAU - Elballal, Mohammed S
AU  - Elballal MS
AD  - Department of Biochemistry, Faculty of Pharmacy, Badr University in Cairo (BUC), 
      Badr City, Cairo 11829, Egypt.
FAU - El-Dakroury, Walaa A
AU  - El-Dakroury WA
AD  - Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, Badr 
      University in Cairo (BUC), Badr City, Cairo 11829, Egypt.
FAU - AbdelRazek, Mohamed M M
AU  - AbdelRazek MMM
AD  - Department of Pharmacognosy, Faculty of Pharmacy, Badr University in Cairo (BUC), 
      Badr City, Cairo 11829, Egypt.
FAU - Noshy, Mina
AU  - Noshy M
AD  - Clinical Pharmacy Department, Faculty of Pharmacy, King Salman International 
      University (KSIU), SouthSinai, Ras Sudr 46612, Egypt.
FAU - El-Husseiny, Hussein M
AU  - El-Husseiny HM
AD  - Cooperative Department of Veterinary Medicine, Faculty of Agriculture, Tokyo 
      University of Agriculture and Technology, 3-5-8 Saiwai Cho, Fuchu-shi, Tokyo 
      183-8509, Japan; Department of Surgery, Anesthesiology, and Radiology, Faculty of 
      Veterinary Medicine, Benha University, Moshtohor, Toukh, Elqaliobiya 13736, 
      Egypt.
FAU - Abulsoud, Ahmed I
AU  - Abulsoud AI
AD  - Biochemistry and Molecular Biology Department, Faculty of Pharmacy (Boys), 
      Al-Azhar University, Nasr City 11231, Cairo, Egypt; Department of Biochemistry 
      and Biotechnology, Faculty of Pharmacy, Heliopolis University, Cairo 11785, 
      Egypt.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20230511
PL  - Germany
TA  - Pathol Res Pract
JT  - Pathology, research and practice
JID - 7806109
RN  - 0 (MicroRNAs)
RN  - 0 (Transforming Growth Factor beta)
SB  - IM
MH  - Humans
MH  - *MicroRNAs/genetics
MH  - *Esophageal Neoplasms/pathology
MH  - Wnt Signaling Pathway/genetics
MH  - Transforming Growth Factor beta/metabolism
MH  - Epithelial-Mesenchymal Transition/genetics
MH  - Gene Expression Regulation, Neoplastic
OTO - NOTNLM
OT  - Chemoresistance
OT  - Epithelial- mesenchymal transition
OT  - Esophageal cancer
OT  - Oncogenic miRNA
OT  - Tumor suppressor miRNA
COIS- Declaration of Competing Interest The authors declare that they have no known 
      competing financial interests or personal relationships that could have appeared 
      to influence the work reported in this paper. The authors have declared that no 
      competing interests exist.
EDAT- 2023/05/18 01:07
MHDA- 2023/05/25 06:42
CRDT- 2023/05/17 18:05
PHST- 2023/04/14 00:00 [received]
PHST- 2023/05/06 00:00 [revised]
PHST- 2023/05/08 00:00 [accepted]
PHST- 2023/05/25 06:42 [medline]
PHST- 2023/05/18 01:07 [pubmed]
PHST- 2023/05/17 18:05 [entrez]
AID - S0344-0338(23)00229-7 [pii]
AID - 10.1016/j.prp.2023.154529 [doi]
PST - ppublish
SO  - Pathol Res Pract. 2023 Jun;246:154529. doi: 10.1016/j.prp.2023.154529. Epub 2023 
      May 11.