PMID- 37196603
OWN - NLM
STAT- MEDLINE
DCOM- 20230529
LR  - 20230529
IS  - 1724-191X (Electronic)
IS  - 1120-1797 (Linking)
VI  - 110
DP  - 2023 Jun
TI  - Knowledge-based plan optimization for prostate SBRT delivered with CyberKnife 
      according to RTOG0938 protocol.
PG  - 102606
LID - S1120-1797(23)00083-2 [pii]
LID - 10.1016/j.ejmp.2023.102606 [doi]
AB  - PURPOSE: To extend the knowledge-based (KB) automatic planning approach to 
      CyberKnife in the case of Stereotactic Body Radiation Therapy (SBRT) for prostate 
      cancer. METHODS: Seventy-two clinical plans of patients treated according to the 
      RTOG0938 protocol (36.25 Gy/5fr) with CyberKnife were exported from the 
      CyberKnife system to Eclipse to train a KB-model using the Rapid Plan tool. The 
      KB approach provided dose-volume objectives for specific OARs only and not PTV. 
      Bladder, rectum and femoral heads were considered in the model. The KB-model was 
      successfully trained on 51 plans and then validated on 20 new patients. A 
      KB-based template was tuned in the Precision system for both sequential 
      optimization (SO) and VOLO optimization algorithms. Plans of the validation group 
      were re-optimized (KB-TP) using both algorithms without any operator intervention 
      and compared against the original plans (TP) in terms of OARs/PTV dose-volume 
      parameters. Paired Wilcoxon signed-rank tests were performed to assess 
      statistically significant differences (p < 0.05). RESULTS: Regarding SO, 
      automatic KB-TP plans were generally better than or equivalent to TP plans. PTVs 
      V95% was slightly worse while OARs sparing for KB-TP was significantly improved. 
      Regarding VOLO optimization, the PTVs coverage was significantly better for KB-TP 
      while there was a limited worsening in the rectum. A significant improvement was 
      observed in the bladder in the range of low-intermediate doses. CONCLUSIONS: An 
      extension of the KB optimization approach to the CyberKnife system has been 
      successfully developed and validated in the case of SBRT prostate cancer.
CI  - Copyright (c) 2023 Associazione Italiana di Fisica Medica e Sanitaria. Published by 
      Elsevier Ltd. All rights reserved.
FAU - Monticelli, Davide
AU  - Monticelli D
AD  - Universita degli Studi di Milano, Milano, Italy; Medical Physics Department, 
      IRCCS San Raffaele Scientific Institute, Milano, Italy.
FAU - Castriconi, Roberta
AU  - Castriconi R
AD  - Medical Physics Department, IRCCS San Raffaele Scientific Institute, Milano, 
      Italy. Electronic address: castriconi.roberta@hsr.it.
FAU - Tudda, Alessia
AU  - Tudda A
AD  - Universita degli Studi di Milano, Milano, Italy; Medical Physics Department, 
      IRCCS San Raffaele Scientific Institute, Milano, Italy.
FAU - Fodor, Andrei
AU  - Fodor A
AD  - Department of Radiation Oncology, IRCCS San Raffaele Scientific Institute, 
      Milano, Italy.
FAU - Deantoni, Chiara
AU  - Deantoni C
AD  - Department of Radiation Oncology, IRCCS San Raffaele Scientific Institute, 
      Milano, Italy.
FAU - Gisella Di Muzio, Nadia
AU  - Gisella Di Muzio N
AD  - Department of Radiation Oncology, IRCCS San Raffaele Scientific Institute, 
      Milano, Italy.
FAU - Mangili, Paola
AU  - Mangili P
AD  - Medical Physics Department, IRCCS San Raffaele Scientific Institute, Milano, 
      Italy.
FAU - Del Vecchio, Antonella
AU  - Del Vecchio A
AD  - Medical Physics Department, IRCCS San Raffaele Scientific Institute, Milano, 
      Italy.
FAU - Fiorino, Claudio
AU  - Fiorino C
AD  - Medical Physics Department, IRCCS San Raffaele Scientific Institute, Milano, 
      Italy.
FAU - Broggi, Sara
AU  - Broggi S
AD  - Medical Physics Department, IRCCS San Raffaele Scientific Institute, Milano, 
      Italy.
LA  - eng
PT  - Journal Article
DEP - 20230515
PL  - Italy
TA  - Phys Med
JT  - Physica medica : PM : an international journal devoted to the applications of 
      physics to medicine and biology : official journal of the Italian Association of 
      Biomedical Physics (AIFB)
JID - 9302888
SB  - IM
MH  - Male
MH  - Humans
MH  - Prostate
MH  - *Radiosurgery/methods
MH  - Radiotherapy Dosage
MH  - Radiotherapy Planning, Computer-Assisted/methods
MH  - *Prostatic Neoplasms/radiotherapy
MH  - *Radiotherapy, Intensity-Modulated/methods
MH  - Organs at Risk
OTO - NOTNLM
OT  - CyberKnife
OT  - Knowledge-based planning
OT  - Prostate cancer
OT  - SBRT
COIS- Declaration of Competing Interest The authors declare that they have no known 
      competing financial interests or personal relationships that could have appeared 
      to influence the work reported in this paper.
EDAT- 2023/05/18 01:07
MHDA- 2023/05/29 06:41
CRDT- 2023/05/17 18:09
PHST- 2022/12/12 00:00 [received]
PHST- 2023/05/04 00:00 [revised]
PHST- 2023/05/04 00:00 [accepted]
PHST- 2023/05/29 06:41 [medline]
PHST- 2023/05/18 01:07 [pubmed]
PHST- 2023/05/17 18:09 [entrez]
AID - S1120-1797(23)00083-2 [pii]
AID - 10.1016/j.ejmp.2023.102606 [doi]
PST - ppublish
SO  - Phys Med. 2023 Jun;110:102606. doi: 10.1016/j.ejmp.2023.102606. Epub 2023 May 15.