PMID- 37196824 OWN - NLM STAT- MEDLINE DCOM- 20230619 LR - 20240121 IS - 1873-6815 (Electronic) IS - 0531-5565 (Linking) VI - 178 DP - 2023 Jul TI - Device-measured physical activity behaviours, and physical function, in people with type 2 diabetes mellitus and peripheral artery disease: A cross-sectional study. PG - 112207 LID - S0531-5565(23)00128-6 [pii] LID - 10.1016/j.exger.2023.112207 [doi] AB - AIM: To quantify differences in device-measured physical activity (PA) behaviours, and physical function (PF), in people with type 2 diabetes mellitus (T2DM) with and without peripheral artery disease (PAD). MATERIALS AND METHODS: Participants from the Chronotype of Patients with T2DM and Effect on Glycaemic Control cross-sectional study wore accelerometers on their non-dominant wrist for up to 8-days to quantify: volume and intensity distribution of PA, time spent inactive, time in light PA, moderate-to-vigorous PA in at least 1-minute bouts (MVPA1min), and the average intensity achieved during the most active continuous 2, 5, 10, 30, and 60-minute periods of the 24-h day. PF was assessed using the short physical performance battery (SPPB), the Duke Activity Status Index (DASI), sit-to-stand repetitions in 60 s (STS-60); hand-grip strength was also assessed. Differences between subjects with and without PAD were estimated using regressions adjusted for possible confounders. RESULTS: 736 participants with T2DM (without diabetic foot ulcers) were included in the analysis, 689 had no PAD. People with T2DM and PAD undertake less PA (MVPA1min: -9.2 min [95 % CI: -15.3 to -3.0; p = 0.004]) (light intensity PA: -18.7 min [-36.4 to -1.0; p = 0.039]), spend more time inactive (49.2 min [12.1 to 86.2; p = 0.009]), and have reduced PF (SPPB score: -1.6 [-2.5 to -0.8; p = 0.001]) (DASI score: -14.8 [-19.8 to -9.8; p = 0.001]) (STS-60 repetitions: -7.1 [-10.5 to -3.8; p = 0.001]) compared to people without; some differences in PA were attenuated by confounders. Reduced intensity of activity for the most active continuous 2-30 min in the 24-h day, and reduced PF, persisted after accounting for confounders. There were no significant differences in hand-grip strength. CONCLUSIONS: Findings from this cross-sectional study suggest that, the presence of PAD in T2DM may have been associated with lower PA levels and PF. CI - Copyright (c) 2023 The Authors. Published by Elsevier Inc. All rights reserved. FAU - Perks, Jemma AU - Perks J AD - Department of Cardiovascular Sciences, University of Leicester, Leicester, UK. Electronic address: jperksphd@gmail.com. FAU - Zaccardi, Francesco AU - Zaccardi F AD - Diabetes Research Centre, University Hospitals of Leicester NHS Trust, Leicester, UK. FAU - Rayt, Harjeet AU - Rayt H AD - Department of Cardiovascular Sciences, University of Leicester, Leicester, UK. FAU - Sayers, Robert AU - Sayers R AD - Department of Cardiovascular Sciences, University of Leicester, Leicester, UK. FAU - Brady, Emer M AU - Brady EM AD - Department of Cardiovascular Sciences, University of Leicester, Leicester, UK. FAU - Davies, Melanie J AU - Davies MJ AD - Diabetes Research Centre, University Hospitals of Leicester NHS Trust, Leicester, UK; NIHR Leicester Biomedical Research Centre and Diabetes Research Centre, College of Life Sciences, University of Leicester, Leicester, UK. FAU - Rowlands, Alex V AU - Rowlands AV AD - Diabetes Research Centre, University Hospitals of Leicester NHS Trust, Leicester, UK; NIHR Leicester Biomedical Research Centre and Diabetes Research Centre, College of Life Sciences, University of Leicester, Leicester, UK. FAU - Edwardson, Charlotte L AU - Edwardson CL AD - Diabetes Research Centre, University Hospitals of Leicester NHS Trust, Leicester, UK; NIHR Leicester Biomedical Research Centre and Diabetes Research Centre, College of Life Sciences, University of Leicester, Leicester, UK. FAU - Hall, Andrew AU - Hall A AD - The Hanning Sleep Laboratory, University Hospitals of Leicester NHS Trust, Leicester, UK. FAU - Yates, Thomas AU - Yates T AD - Diabetes Research Centre, University Hospitals of Leicester NHS Trust, Leicester, UK; NIHR Leicester Biomedical Research Centre and Diabetes Research Centre, College of Life Sciences, University of Leicester, Leicester, UK. FAU - Henson, Joseph AU - Henson J AD - Diabetes Research Centre, University Hospitals of Leicester NHS Trust, Leicester, UK; NIHR Leicester Biomedical Research Centre and Diabetes Research Centre, College of Life Sciences, University of Leicester, Leicester, UK. LA - eng PT - Journal Article DEP - 20230524 PL - England TA - Exp Gerontol JT - Experimental gerontology JID - 0047061 SB - IM MH - Humans MH - *Diabetes Mellitus, Type 2 MH - Cross-Sectional Studies MH - Exercise MH - Sedentary Behavior MH - *Peripheral Arterial Disease/complications OTO - NOTNLM OT - Peripheral artery disease OT - Physical activity COIS- Conflict of interest J.P. is funded and R.S. part-funded, by a charitable donation from the George Davies Charitable Trust. M.D. has acted as consultant, advisory board member and speaker for Boehringer Ingelheim, Lilly, Novo Nordisk and Sanofi, an advisory board member and speaker for AstraZeneca, an advisory board member for Janssen, Lexicon, Pfizer and ShouTi Pharma Inc. and as a speaker for Napp Pharmaceuticals, Novartis and Takeda Pharmaceuticals International Inc.; and has received grants in support of investigator and investigator initiated trials from Novo Nordisk, Sanofi-Aventis, Lilly, Boehringer Ingelheim, Astrazeneca and Janssen. All other authors declare no support from any organisation for the submitted work, no financial relationships with any organisations that might have an interest in the submitted work in the previous three years, no other relationships or activities that could appear to have influenced the submitted work. EDAT- 2023/05/18 01:07 MHDA- 2023/06/19 13:08 CRDT- 2023/05/17 19:25 PHST- 2023/03/28 00:00 [received] PHST- 2023/05/11 00:00 [revised] PHST- 2023/05/14 00:00 [accepted] PHST- 2023/06/19 13:08 [medline] PHST- 2023/05/18 01:07 [pubmed] PHST- 2023/05/17 19:25 [entrez] AID - S0531-5565(23)00128-6 [pii] AID - 10.1016/j.exger.2023.112207 [doi] PST - ppublish SO - Exp Gerontol. 2023 Jul;178:112207. doi: 10.1016/j.exger.2023.112207. Epub 2023 May 24.