PMID- 37196984
OWN - NLM
STAT- MEDLINE
DCOM- 20231110
LR  - 20240312
IS  - 2451-9030 (Electronic)
IS  - 2451-9022 (Print)
IS  - 2451-9022 (Linking)
VI  - 8
IP  - 11
DP  - 2023 Nov
TI  - Replicable Patterns of Memory Impairments in Children With Autism and Their Links 
      to Hyperconnected Brain Circuits.
PG  - 1113-1123
LID - S2451-9022(23)00121-0 [pii]
LID - 10.1016/j.bpsc.2023.05.002 [doi]
AB  - BACKGROUND: Memory impairments have profound implications for social 
      communication and educational outcomes in children with autism spectrum disorder 
      (ASD). However, the precise nature of memory dysfunction in children with ASD and 
      the underlying neural circuit mechanisms remain poorly understood. The default 
      mode network (DMN) is a brain network that is associated with memory and 
      cognitive function, and DMN dysfunction is among the most replicable and robust 
      brain signatures of ASD. METHODS: We used a comprehensive battery of standardized 
      episodic memory assessments and functional circuit analyses in 25 8- to 
      12-year-old children with ASD and 29 matched typically developing control 
      children. RESULTS: Memory performance was reduced in children with ASD compared 
      with control children. General and face memory emerged as distinct dimensions of 
      memory difficulties in ASD. Importantly, findings of diminished episodic memory 
      in children with ASD were replicated in 2 independent data sets. Analysis of 
      intrinsic functional circuits associated with the DMN revealed that general and 
      face memory deficits were associated with distinct, hyperconnected circuits: 
      Aberrant hippocampal connectivity predicted diminished general memory while 
      aberrant posterior cingulate cortex connectivity predicted diminished face 
      memory. Notably, aberrant hippocampal-posterior cingulate cortex circuitry was a 
      common feature of diminished general and face memory in ASD. CONCLUSIONS: Our 
      results represent a comprehensive appraisal of episodic memory function in 
      children with ASD and identify extensive and replicable patterns of memory 
      reductions in children with ASD that are linked to dysfunction of distinct 
      DMN-related circuits. These findings highlight a role for DMN dysfunction in ASD 
      that extends beyond face memory to general memory function.
CI  - Copyright (c) 2023 Society of Biological Psychiatry. Published by Elsevier Inc. All 
      rights reserved.
FAU - Liu, Jin
AU  - Liu J
AD  - Department of Psychiatry & Behavioral Sciences, Stanford University School of 
      Medicine, Stanford, California. Electronic address: jinliu5@stanford.edu.
FAU - Chen, Lang
AU  - Chen L
AD  - Department of Psychology, Santa Clara University, Santa Clara, California.
FAU - Chang, Hyesang
AU  - Chang H
AD  - Department of Psychiatry & Behavioral Sciences, Stanford University School of 
      Medicine, Stanford, California.
FAU - Rudoler, Jeremy
AU  - Rudoler J
AD  - Department of Psychiatry & Behavioral Sciences, Stanford University School of 
      Medicine, Stanford, California.
FAU - Al-Zughoul, Ahmad Belal
AU  - Al-Zughoul AB
AD  - Department of Psychiatry & Behavioral Sciences, Stanford University School of 
      Medicine, Stanford, California.
FAU - Kang, Julia Boram
AU  - Kang JB
AD  - Department of Psychiatry & Behavioral Sciences, Stanford University School of 
      Medicine, Stanford, California.
FAU - Abrams, Daniel A
AU  - Abrams DA
AD  - Department of Psychiatry & Behavioral Sciences, Stanford University School of 
      Medicine, Stanford, California; Wu Tsai Stanford Neurosciences Institute, 
      Stanford University School of Medicine, Stanford, California.
FAU - Menon, Vinod
AU  - Menon V
AD  - Department of Psychiatry & Behavioral Sciences, Stanford University School of 
      Medicine, Stanford, California; Department of Neurology & Neurological Sciences, 
      Stanford University School of Medicine, Stanford, California; Wu Tsai Stanford 
      Neurosciences Institute, Stanford University School of Medicine, Stanford, 
      California. Electronic address: menon@stanford.edu.
LA  - eng
GR  - R01 MH121069/MH/NIMH NIH HHS/United States
GR  - R01 MH084164/MH/NIMH NIH HHS/United States
GR  - R21 DC017950/DC/NIDCD NIH HHS/United States
GR  - R37 HD094623/HD/NICHD NIH HHS/United States
GR  - R01 HD059205/HD/NICHD NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20230515
PL  - United States
TA  - Biol Psychiatry Cogn Neurosci Neuroimaging
JT  - Biological psychiatry. Cognitive neuroscience and neuroimaging
JID - 101671285
SB  - IM
MH  - Humans
MH  - Child
MH  - *Autism Spectrum Disorder
MH  - *Autistic Disorder/complications
MH  - Brain Mapping/methods
MH  - Magnetic Resonance Imaging/methods
MH  - Neural Pathways
MH  - Brain
MH  - Memory Disorders/etiology
PMC - PMC10646152
MID - NIHMS1916954
OTO - NOTNLM
OT  - Autism
OT  - Default mode network
OT  - Episodic memory
OT  - Face memory
OT  - Hippocampus
OT  - Posterior cingulate cortex
OT  - Recollection and familiarity
COIS- Competing interests The authors report no biomedical financial interests or 
      potential conflicts of interest.
EDAT- 2023/05/18 01:07
MHDA- 2023/11/10 06:45
PMCR- 2024/11/01
CRDT- 2023/05/17 19:29
PHST- 2022/10/07 00:00 [received]
PHST- 2023/04/07 00:00 [revised]
PHST- 2023/05/09 00:00 [accepted]
PHST- 2024/11/01 00:00 [pmc-release]
PHST- 2023/11/10 06:45 [medline]
PHST- 2023/05/18 01:07 [pubmed]
PHST- 2023/05/17 19:29 [entrez]
AID - S2451-9022(23)00121-0 [pii]
AID - 10.1016/j.bpsc.2023.05.002 [doi]
PST - ppublish
SO  - Biol Psychiatry Cogn Neurosci Neuroimaging. 2023 Nov;8(11):1113-1123. doi: 
      10.1016/j.bpsc.2023.05.002. Epub 2023 May 15.