PMID- 37198158
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20230531
IS  - 1674-8301 (Print)
IS  - 2352-4685 (Electronic)
IS  - 1674-8301 (Linking)
VI  - 37
IP  - 3
DP  - 2023 Apr 15
TI  - Dysfunction of the neurovascular unit in brain aging.
PG  - 153-165
LID - 10.7555/JBR.36.20220105 [doi]
AB  - An emerging concept termed the neurovascular unit (NVU) underlines neurovascular 
      coupling. It has been reported that NVU impairment can result in 
      neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease. 
      Aging is a complex and irreversible process caused by programmed and 
      damage-related factors. Loss of biological functions and increased susceptibility 
      to additional neurodegenerative diseases are major characteristics of aging. In 
      this review, we describe the basics of the NVU and discuss the effect of aging on 
      NVU basics. Furthermore, we summarize the mechanisms that increase NVU 
      susceptibility to neurodegenerative diseases, such as Alzheimer's disease and 
      Parkinson's disease. Finally, we discuss new treatments for neurodegenerative 
      diseases and methods of maintaining an intact NVU that may delay or diminish 
      aging.
FAU - Liu, Shu
AU  - Liu S
AD  - Chongqing Medical University, Chongqing 400042, China.
AD  - Chongqing Institute Green and Intelligent Technology, Chinese Academy of 
      Sciences, Chongqing 400714, China.
AD  - Chongqing School, University of Chinese Academy of Sciences, Chongqing 400714, 
      China.
AD  - Department of Neurology, Chongqing General Hospital, Chongqing 400013, China.
AD  - Chongqing Key Laboratory of Neurodegenerative Diseases, Chongqing 400013, China.
FAU - Yang, Xu
AU  - Yang X
AD  - Department of Neurology, Chongqing General Hospital, Chongqing 400013, China.
AD  - Chongqing Key Laboratory of Neurodegenerative Diseases, Chongqing 400013, China.
FAU - Chen, Fei
AU  - Chen F
AD  - Chongqing Medical University, Chongqing 400042, China.
AD  - Chongqing Institute Green and Intelligent Technology, Chinese Academy of 
      Sciences, Chongqing 400714, China.
FAU - Cai, Zhiyou
AU  - Cai Z
AD  - Chongqing Medical University, Chongqing 400042, China.
AD  - Chongqing Institute Green and Intelligent Technology, Chinese Academy of 
      Sciences, Chongqing 400714, China.
AD  - Chongqing School, University of Chinese Academy of Sciences, Chongqing 400714, 
      China.
AD  - Department of Neurology, Chongqing General Hospital, Chongqing 400013, China.
AD  - Chongqing Key Laboratory of Neurodegenerative Diseases, Chongqing 400013, China.
LA  - eng
PT  - Journal Article
PL  - China
TA  - J Biomed Res
JT  - Journal of biomedical research
JID - 101551157
PMC - PMC10226086
OTO - NOTNLM
OT  - Alzheimer's disease
OT  - Parkinson's disease
OT  - aging
OT  - neurovascular unit
COIS- The authors reported no conflict of interests.
EDAT- 2023/05/18 01:07
MHDA- 2023/05/18 01:08
PMCR- 2023/05/01
CRDT- 2023/05/17 23:14
PHST- 2023/05/18 01:08 [medline]
PHST- 2023/05/18 01:07 [pubmed]
PHST- 2023/05/17 23:14 [entrez]
PHST- 2023/05/01 00:00 [pmc-release]
AID - jbr-37-3-153 [pii]
AID - 10.7555/JBR.36.20220105 [doi]
PST - ppublish
SO  - J Biomed Res. 2023 Apr 15;37(3):153-165. doi: 10.7555/JBR.36.20220105.