PMID- 37198280
OWN - NLM
STAT- MEDLINE
DCOM- 20230519
LR  - 20230606
IS  - 2045-2322 (Electronic)
IS  - 2045-2322 (Linking)
VI  - 13
IP  - 1
DP  - 2023 May 17
TI  - Effects of folic acid supplementation in pregnant mice on glucose metabolism 
      disorders in male offspring induced by lipopolysaccharide exposure during 
      pregnancy.
PG  - 7984
LID - 10.1038/s41598-023-31690-w [doi]
LID - 7984
AB  - The DOHaD theory suggests that adverse environmental factors in early life may 
      lead to the development of metabolic diseases including diabetes and hypertension 
      in adult offspring through epigenetic mechanisms such as DNA methylation. Folic 
      acid (FA) is an important methyl donor in vivo and participates in DNA 
      replication and methylation. The preliminary experimental results of our group 
      demonstrated that lipopolysaccharide (LPS, 50 microg/kg/d) exposure during pregnancy 
      could lead to glucose metabolism disorders in male offspring, but not female 
      offspring; however, the effect of folic acid supplementation on glucose 
      metabolism disorders in male offspring induced by LPS exposure remains unclear. 
      Therefore, in this study, pregnant mice were exposed to LPS on gestational day 
      (GD) 15-17 and were given three doses of FA supplementation (2 mg/kg, 5 mg/kg, or 
      40 mg/kg) from mating to lactation to explore its effect on glucose metabolism in 
      male offspring and the potential mechanism. This study confirmed that FA 
      supplementation of 5 mg/kg in pregnant mice improved glucose metabolism in 
      LPS-exposed offspring during pregnancy by regulating gene expression.
CI  - (c) 2023. The Author(s).
FAU - Sun, Wan-Xiao
AU  - Sun WX
AD  - Department of Basic Nursing, School of Nursing, Anhui Medical University, 81 
      Meishan Road, Hefei, 230032, Anhui, China.
AD  - Anhui Medical College, Hefei, 230601, Anhui, China.
FAU - Shu, Yi-Ping
AU  - Shu YP
AD  - Department of Basic Nursing, School of Nursing, Anhui Medical University, 81 
      Meishan Road, Hefei, 230032, Anhui, China.
AD  - The First Affiliated Hospital of Anhui Medical University, Hefei, 230601, Anhui, 
      China.
FAU - Yang, Xin-Yu
AU  - Yang XY
AD  - Department of Basic Nursing, School of Nursing, Anhui Medical University, 81 
      Meishan Road, Hefei, 230032, Anhui, China.
FAU - Huang, Wei
AU  - Huang W
AD  - Department of Basic Nursing, School of Nursing, Anhui Medical University, 81 
      Meishan Road, Hefei, 230032, Anhui, China.
FAU - Chen, Jing
AU  - Chen J
AD  - Department of Basic Nursing, School of Nursing, Anhui Medical University, 81 
      Meishan Road, Hefei, 230032, Anhui, China.
AD  - Anhui Provincial Hospital, Hefei, 230022, Anhui, China.
FAU - Yu, Ning-Ning
AU  - Yu NN
AD  - Department of Basic Nursing, School of Nursing, Anhui Medical University, 81 
      Meishan Road, Hefei, 230032, Anhui, China.
AD  - The First Affiliated Hospital of Anhui Medical University, Hefei, 230601, Anhui, 
      China.
FAU - Zhao, Mei
AU  - Zhao M
AD  - Department of Basic Nursing, School of Nursing, Anhui Medical University, 81 
      Meishan Road, Hefei, 230032, Anhui, China. zhaomei@ahmu.edu.cn.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20230517
PL  - England
TA  - Sci Rep
JT  - Scientific reports
JID - 101563288
RN  - 0 (Lipopolysaccharides)
RN  - 935E97BOY8 (Folic Acid)
RN  - IY9XDZ35W2 (Glucose)
SB  - IM
MH  - Pregnancy
MH  - Female
MH  - Humans
MH  - Animals
MH  - Mice
MH  - Male
MH  - Lipopolysaccharides/adverse effects
MH  - *Prenatal Exposure Delayed Effects/chemically induced
MH  - Folic Acid/adverse effects
MH  - *Glucose Metabolism Disorders
MH  - Dietary Supplements
MH  - Glucose/metabolism
PMC - PMC10192134
COIS- The authors declare no competing interests.
EDAT- 2023/05/18 01:07
MHDA- 2023/05/19 06:42
PMCR- 2023/05/17
CRDT- 2023/05/17 23:22
PHST- 2022/06/30 00:00 [received]
PHST- 2023/03/15 00:00 [accepted]
PHST- 2023/05/19 06:42 [medline]
PHST- 2023/05/18 01:07 [pubmed]
PHST- 2023/05/17 23:22 [entrez]
PHST- 2023/05/17 00:00 [pmc-release]
AID - 10.1038/s41598-023-31690-w [pii]
AID - 31690 [pii]
AID - 10.1038/s41598-023-31690-w [doi]
PST - epublish
SO  - Sci Rep. 2023 May 17;13(1):7984. doi: 10.1038/s41598-023-31690-w.