PMID- 37198732
OWN - NLM
STAT- MEDLINE
DCOM- 20230531
LR  - 20230531
IS  - 1520-6882 (Electronic)
IS  - 0003-2700 (Linking)
VI  - 95
IP  - 21
DP  - 2023 May 30
TI  - Conformal Hydrogel-Skin Coating on a Microfluidic Channel through Microstamping 
      Transfer of the Masking Layer.
PG  - 8332-8339
LID - 10.1021/acs.analchem.3c00812 [doi]
AB  - Poly(dimethylsiloxane) (PDMS) is used in microfluidics owing to its 
      biocompatibility and simple fabrication. However, its intrinsic hydrophobicity 
      and biofouling inhibit its microfluidic applications. Conformal hydrogel-skin 
      coating for PDMS microchannels, involving the microstamping transfer of the 
      masking layer, is reported herein. A selective uniform hydrogel layer with a 
      thickness of  approximately 1 mum was coated in diverse PDMS microchannels with a resolution of 
       approximately 3 mum, maintaining its structure and hydrophilicity after 180 days (6 months). 
      The wettability transition of PDMS was demonstrated through the switched 
      emulsification in a flow-focusing device (water-in-oil [pristine PDMS] to 
      oil-in-water [hydrophilic PDMS]). A one-step bead-based immunoassay was performed 
      to detect the anti-severe acute respiratory syndrome coronavirus 2 IgG using a 
      hydrogel-skin-coated point-of-care platform.
FAU - Lee, Wonhyung
AU  - Lee W
AUID- ORCID: 0000-0002-9486-535X
AD  - Department of Mechanical Engineering, Pohang University of Science and Technology 
      (POSTECH), 77 Cheongam-ro, Nam-gu, Pohang-si 37673, Gyeongsangbuk-do, Republic of 
      Korea.
FAU - Lim, Jongkyeong
AU  - Lim J
AUID- ORCID: 0000-0003-1070-7360
AD  - Department of Mechanical Engineering, Gachon University, 1342 Seongnam-daero, 
      Sujeong-gu, Seongnam-si 13120, Gyeonggi-do, Republic of Korea.
FAU - Kim, Joonwon
AU  - Kim J
AUID- ORCID: 0000-0001-6424-7000
AD  - Department of Mechanical Engineering, Pohang University of Science and Technology 
      (POSTECH), 77 Cheongam-ro, Nam-gu, Pohang-si 37673, Gyeongsangbuk-do, Republic of 
      Korea.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20230517
PL  - United States
TA  - Anal Chem
JT  - Analytical chemistry
JID - 0370536
RN  - 0 (Hydrogels)
RN  - 0 (Dimethylpolysiloxanes)
RN  - 059QF0KO0R (Water)
SB  - IM
MH  - Humans
MH  - *Microfluidics
MH  - Hydrogels
MH  - *COVID-19
MH  - Dimethylpolysiloxanes/chemistry
MH  - Wettability
MH  - Water
EDAT- 2023/05/18 06:42
MHDA- 2023/05/31 06:41
CRDT- 2023/05/18 00:13
PHST- 2023/05/31 06:41 [medline]
PHST- 2023/05/18 06:42 [pubmed]
PHST- 2023/05/18 00:13 [entrez]
AID - 10.1021/acs.analchem.3c00812 [doi]
PST - ppublish
SO  - Anal Chem. 2023 May 30;95(21):8332-8339. doi: 10.1021/acs.analchem.3c00812. Epub 
      2023 May 17.