PMID- 37199148
OWN - NLM
STAT- MEDLINE
DCOM- 20231116
LR  - 20231116
IS  - 0392-856X (Print)
IS  - 0392-856X (Linking)
VI  - 41
IP  - 11
DP  - 2023 Nov
TI  - Association of polycyclic aromatic hydrocarbons with osteoarthritis among adults: 
      an analysis of the NHANES 2001-2016.
PG  - 2239-2248
LID - 10.55563/clinexprheumatol/6xjdfn [doi]
AB  - OBJECTIVES: Polycyclic aromatic hydrocarbons (PAHs) are environmental 
      endocrine-disrupting compounds, which have been widely recognised as a risk 
      factor for human health. However, the relationship between PAHs exposure and the 
      risk of osteoarthritis has rarely been reported. This study aimed to investigate 
      the association between individual and mixed exposure to PAHs and osteoarthritis. 
      METHODS: In this cross-sectional study, participants aged >/=20 years with data on 
      urinary PAHs and osteoarthritis were extracted from the National Health and 
      Nutrition Examination Survey (NHANES) between 2001 and 2016. Logistic regression 
      analysis was utilised to assess the relationship between individual PAHs exposure 
      and osteoarthritis. The quantile-based g computation (qgcomp) analysis and 
      Bayesian kernel machine regression (BKMR) analysis were performed to assess the 
      effect of mixed exposure to PAHs on osteoarthritis, respectively. RESULTS: A 
      total of 10,613 participants were enrolled, 980 (9.23%) of whom had 
      osteoarthritis. Exposure to high levels of 1-hydroxynaphthalene (1-NAP) [odds 
      ratio (OR)=1.06, 95% confidence interval (CI): 1.01-1.10], 3-hydroxyfluorene 
      (3-FLU) (OR=1.09, 95%CI: 1.02-1.17), and 2-hydroxyfluorene (2-FLU) (OR=1.06, 
      95%CI: 1.01-1.13) were all associated with greater odds of osteoarthritis after 
      adjusting for age, sex, body mass index, drinking alcohol, and hypertension. The 
      qgcomp analysis showed that the joint weighted value of mixed PAHs exposure 
      (OR=1.11, 95%CI: 1.02-1.22; p=0.017) was significantly related to higher odds of 
      osteoarthritis. The BKMR analysis demonstrated that mixed exposure to PAHs was 
      positively correlated with the risk of osteoarthritis. CONCLUSIONS: Both 
      individual and mixed exposure to PAHs were positively correlated with the risk of 
      osteoarthritis.
FAU - Lu, Zhihua
AU  - Lu Z
AD  - School of Medicine, Yangzhou Polytechnic College, Yangzhou, China.
FAU - Chen, Yonghua
AU  - Chen Y
AD  - Department of Orthopaedics, Huzhou Traditional Chinese Medicine Hospital 
      Affiliated to Zhejiang Chinese Medical University, Huzhou, China. 
      cyonghuadct@outlook.com.
LA  - eng
PT  - Journal Article
DEP - 20230515
PL  - Italy
TA  - Clin Exp Rheumatol
JT  - Clinical and experimental rheumatology
JID - 8308521
RN  - 0 (Polycyclic Aromatic Hydrocarbons)
RN  - 0 (Biomarkers)
SB  - IM
MH  - Adult
MH  - Humans
MH  - *Polycyclic Aromatic Hydrocarbons/adverse effects
MH  - Nutrition Surveys
MH  - Cross-Sectional Studies
MH  - Bayes Theorem
MH  - Biomarkers
MH  - *Osteoarthritis/chemically induced/epidemiology
EDAT- 2023/05/18 06:42
MHDA- 2023/11/16 06:45
CRDT- 2023/05/18 05:32
PHST- 2023/02/07 00:00 [received]
PHST- 2023/04/17 00:00 [accepted]
PHST- 2023/11/16 06:45 [medline]
PHST- 2023/05/18 06:42 [pubmed]
PHST- 2023/05/18 05:32 [entrez]
AID - 19628 [pii]
AID - 10.55563/clinexprheumatol/6xjdfn [doi]
PST - ppublish
SO  - Clin Exp Rheumatol. 2023 Nov;41(11):2239-2248. doi: 
      10.55563/clinexprheumatol/6xjdfn. Epub 2023 May 15.