PMID- 37199797
OWN - NLM
STAT- MEDLINE
DCOM- 20230724
LR  - 20230810
IS  - 1432-5233 (Electronic)
IS  - 0940-5429 (Linking)
VI  - 60
IP  - 9
DP  - 2023 Sep
TI  - Prevalence and contributing factors of impaired awareness of hypoglycemia in 
      patients with type 2 diabetes: a meta-analysis.
PG  - 1155-1169
LID - 10.1007/s00592-023-02102-2 [doi]
AB  - AIMS: To conduct a systematic review to summarize the definition, measurement 
      tools, prevalence, and contributing factors of impaired awareness of hypoglycemia 
      (IAH) in type 2 diabetes mellitus (T2DM). METHODS: A reproducible search strategy 
      was used to identify factors affecting IAH in T2DM in PubMed, MEDLINE, EMBASE, 
      Cochrane, PsycINFO, and CINAHL from inception until 2022. Literature screening, 
      quality evaluation, and information extraction were performed independently by 2 
      investigators. A meta-analysis of prevalence was performed using Stata 17.0. 
      RESULTS: The pooled prevalence of IAH in patients with T2DM was 22% 
      (95%CI:14-29%). Measurement tools included the Gold score, Clarke's 
      questionnaire, and the Pedersen-Bjergaard scale. IAH in T2DM was associated with 
      sociodemographic factors (age, BMI, ethnicity, marital status, education level, 
      and type of pharmacy patients visited), clinical disease factors (disease 
      duration, HbAlc, complications, insulin therapy regimen, sulfonylureas use, and 
      the frequency and severity of hypoglycemia), and behavior and lifestyle (smoking 
      and medication adherence). CONCLUSION: The study found a high prevalence of IAH 
      in T2DM, with an increased risk of severe hypoglycemia, suggesting that medical 
      workers should take targeted measures to address sociodemographic factors, 
      clinical disease, and behavior and lifestyle to reduce IAH in T2DM and thus 
      reduce hypoglycemia in patients.
CI  - (c) 2023. Springer-Verlag Italia S.r.l., part of Springer Nature.
FAU - Li, Xiang-Ning
AU  - Li XN
AD  - School of Nursing, Yangzhou University, Jiangyang Road 136, Yangzhou, China.
FAU - Kan, Yin-Shi
AU  - Kan YS
AD  - School of Nursing, Yangzhou University, Jiangyang Road 136, Yangzhou, China.
FAU - Liu, Hong-Yuan
AU  - Liu HY
AD  - School of Nursing, Yangzhou University, Jiangyang Road 136, Yangzhou, China.
AD  - Jiangsu Co-Innovation Center for Prevention and Control of Important Animal 
      Infectious Diseases and Zoonoses, Jiangsu Key Laboratory of Zoonosis, Yangzhou 
      University, Yangzhou, China.
FAU - Pang, Juan
AU  - Pang J
AD  - School of Nursing, Yangzhou University, Jiangyang Road 136, Yangzhou, China.
FAU - He, Yu-Ying
AU  - He YY
AD  - School of Nursing, Yangzhou University, Jiangyang Road 136, Yangzhou, China.
FAU - Liu, Lin
AU  - Liu L
AD  - School of Nursing, Yangzhou University, Jiangyang Road 136, Yangzhou, China.
FAU - Zou, Yan
AU  - Zou Y
AD  - School of Nursing, Yangzhou University, Jiangyang Road 136, Yangzhou, China.
FAU - Zhang, Ning
AU  - Zhang N
AD  - School of Nursing, Yangzhou University, Jiangyang Road 136, Yangzhou, China.
FAU - Zhang, Yu
AU  - Zhang Y
AUID- ORCID: 0000-0002-4976-9158
AD  - School of Nursing, Yangzhou University, Jiangyang Road 136, Yangzhou, China. 
      yizhangyu@yzu.edu.cn.
AD  - Jiangsu Co-Innovation Center for Prevention and Control of Important Animal 
      Infectious Diseases and Zoonoses, Jiangsu Key Laboratory of Zoonosis, Yangzhou 
      University, Yangzhou, China. yizhangyu@yzu.edu.cn.
LA  - eng
GR  - 82100870/the National Natural Science Foundation of China/
PT  - Journal Article
PT  - Meta-Analysis
PT  - Review
PT  - Systematic Review
DEP - 20230518
PL  - Germany
TA  - Acta Diabetol
JT  - Acta diabetologica
JID - 9200299
RN  - 0 (Insulin)
RN  - 0 (Hypoglycemic Agents)
SB  - IM
MH  - Humans
MH  - *Diabetes Mellitus, Type 2/complications/drug therapy/epidemiology
MH  - *Diabetes Mellitus, Type 1/complications
MH  - Prevalence
MH  - *Hypoglycemia/epidemiology/etiology/diagnosis
MH  - Insulin/therapeutic use
MH  - Hypoglycemic Agents/adverse effects
OTO - NOTNLM
OT  - Contributing factors
OT  - Impaired awareness of hypoglycemia
OT  - Prevalence
OT  - Type 2 diabetes
EDAT- 2023/05/18 13:09
MHDA- 2023/07/24 06:42
CRDT- 2023/05/18 11:07
PHST- 2023/02/15 00:00 [received]
PHST- 2023/04/18 00:00 [accepted]
PHST- 2023/07/24 06:42 [medline]
PHST- 2023/05/18 13:09 [pubmed]
PHST- 2023/05/18 11:07 [entrez]
AID - 10.1007/s00592-023-02102-2 [pii]
AID - 10.1007/s00592-023-02102-2 [doi]
PST - ppublish
SO  - Acta Diabetol. 2023 Sep;60(9):1155-1169. doi: 10.1007/s00592-023-02102-2. Epub 
      2023 May 18.