PMID- 37200343
OWN - NLM
STAT- MEDLINE
DCOM- 20230522
LR  - 20230605
IS  - 1932-6203 (Electronic)
IS  - 1932-6203 (Linking)
VI  - 18
IP  - 5
DP  - 2023
TI  - Ultrasound evaluation of vagus nerve cross-sectional area in a community-dwelling 
      elderly Japanese cohort.
PG  - e0280661
LID - 10.1371/journal.pone.0280661 [doi]
LID - e0280661
AB  - OBJECTIVES: Although the vagus nerve (VN) is easily observed by ultrasonography, 
      few studies have evaluated the cross-sectional area (CSA) of the VN in healthy 
      older individuals from East Asia. In this study, we aimed to report reference 
      values for the CSA of the VN in community-dwelling elderly Japanese individuals 
      and to identify any associated medical history and/or lifestyle factors. METHODS: 
      The present study included 336 participants aged >/= 70 years from a prospective 
      cohort study conducted in Yahaba, Japan from October 2021 to February 2022. The 
      CSA of the VN was measured bilaterally at the level of the thyroid gland by 
      ultrasonography. Simple linear regression analysis and generalized estimating 
      equation were conducted to identify the associations between clinical and 
      background factors and the CSA of the VN. RESULTS: In our cohort, the median CSA 
      of the VN was 1.3 mm2 (interquartile range [IQR] 1.1-1.6) on the right side and 
      1.2 mm2 (IQR 1.0-1.4) on the left side. Generalized estimating equation showed 
      that history of head injury (beta = 0.19, p < .01), current smoking habit (beta = 
      -0.09, p = .03), and BMI (beta = 0.02, p < .01) were independently associated with 
      the CSA of the VN. CONCLUSION: We have reported reference VN CSA values for 
      community-dwelling elderly Japanese individuals. In addition, we showed that the 
      CSA of the VN was positively associated with a history of head injury and BMI and 
      inversely associated with current smoking habit.
CI  - Copyright: (c) 2023 Oura et al. This is an open access article distributed under 
      the terms of the Creative Commons Attribution License, which permits unrestricted 
      use, distribution, and reproduction in any medium, provided the original author 
      and source are credited.
FAU - Oura, Kazumasa
AU  - Oura K
AUID- ORCID: 0000-0002-2693-7585
AD  - Division of Neurology and Gerontology, Department of Internal Medicine, School of 
      Medicine, Iwate Medical University, Shiwa-Gun, Yahaba-Cho, Iwate, Japan.
FAU - Akasaka, Hiroshi
AU  - Akasaka H
AD  - Division of Neurology and Gerontology, Department of Internal Medicine, School of 
      Medicine, Iwate Medical University, Shiwa-Gun, Yahaba-Cho, Iwate, Japan.
FAU - Ishizuka, Naoki
AU  - Ishizuka N
AD  - Division of Neurology and Gerontology, Department of Internal Medicine, School of 
      Medicine, Iwate Medical University, Shiwa-Gun, Yahaba-Cho, Iwate, Japan.
FAU - Sato, Yuriko
AU  - Sato Y
AD  - Division of Neurology and Gerontology, Department of Internal Medicine, School of 
      Medicine, Iwate Medical University, Shiwa-Gun, Yahaba-Cho, Iwate, Japan.
FAU - Kudo, Masahiro
AU  - Kudo M
AD  - Division of Neurology and Gerontology, Department of Internal Medicine, School of 
      Medicine, Iwate Medical University, Shiwa-Gun, Yahaba-Cho, Iwate, Japan.
FAU - Yamaguchi, Takashi
AU  - Yamaguchi T
AD  - Division of Neurology and Gerontology, Department of Internal Medicine, School of 
      Medicine, Iwate Medical University, Shiwa-Gun, Yahaba-Cho, Iwate, Japan.
FAU - Oura, Mao Yamaguchi
AU  - Oura MY
AD  - Division of Neurology and Gerontology, Department of Internal Medicine, School of 
      Medicine, Iwate Medical University, Shiwa-Gun, Yahaba-Cho, Iwate, Japan.
FAU - Itabashi, Ryo
AU  - Itabashi R
AD  - Division of Neurology and Gerontology, Department of Internal Medicine, School of 
      Medicine, Iwate Medical University, Shiwa-Gun, Yahaba-Cho, Iwate, Japan.
FAU - Maeda, Tetsuya
AU  - Maeda T
AD  - Division of Neurology and Gerontology, Department of Internal Medicine, School of 
      Medicine, Iwate Medical University, Shiwa-Gun, Yahaba-Cho, Iwate, Japan.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20230518
PL  - United States
TA  - PLoS One
JT  - PloS one
JID - 101285081
SB  - IM
MH  - Aged
MH  - Humans
MH  - *East Asian People
MH  - Independent Living
MH  - Prospective Studies
MH  - Ultrasonography
MH  - *Vagus Nerve/anatomy & histology/diagnostic imaging
MH  - Reference Values
PMC - PMC10194966
COIS- The authors have declared that no competing interests exist.
EDAT- 2023/05/18 19:12
MHDA- 2023/05/22 06:42
PMCR- 2023/05/18
CRDT- 2023/05/18 13:44
PHST- 2023/01/11 00:00 [received]
PHST- 2023/05/09 00:00 [accepted]
PHST- 2023/05/22 06:42 [medline]
PHST- 2023/05/18 19:12 [pubmed]
PHST- 2023/05/18 13:44 [entrez]
PHST- 2023/05/18 00:00 [pmc-release]
AID - PONE-D-23-00238 [pii]
AID - 10.1371/journal.pone.0280661 [doi]
PST - epublish
SO  - PLoS One. 2023 May 18;18(5):e0280661. doi: 10.1371/journal.pone.0280661. 
      eCollection 2023.