PMID- 37200753
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20230521
IS  - 2277-9175 (Print)
IS  - 2277-9175 (Electronic)
IS  - 2277-9175 (Linking)
VI  - 12
DP  - 2023
TI  - Vitamin E Prevented Hepatic and Renal Tissue Damage in Hypothyroid Rats.
PG  - 75
LID - 10.4103/abr.abr_275_21 [doi]
LID - 75
AB  - BACKGROUND: Considering antioxidant effects of vitamin E (Vit E), in the present 
      study, the effect of Vit E on liver and kidney functions and oxidative stress 
      parameters in tissues of these organs of hypothyroid (Hypo) rats were reported. 
      MATERIALS AND METHODS: The animals were included in three groups:(1) control, (2) 
      hypo, and (3) hypo-hypo-Vit E. Hypothyroidism was induced in rats by giving 0.05% 
      propylthiouracil (PTU) in drinking water. Besides PTU, the rats in group 3 were 
      daily injected with Vit E (20 mg/kg) for 42 days. The animals were deeply 
      anesthetized and sacrificed, and the serum of the rats was immediately removed to 
      measure thyroxin level and subsequent analysis. The liver and kidney tissues were 
      also immediately removed for biochemical oxidative stress criteria. RESULTS: PTU 
      administration reduced serum thyroxin level and also thiol content, superoxide 
      dismutase (SOD), and catalase (CAT) activities in the liver and kidney tissues 
      while increasing malondialdehyde (MDA). Hypothyroidism also increased alanine 
      aminotransferase (ALT), blood urea nitrogen (BUN), and creatinine while 
      decreasing albumin. Vit E increased thiol, SOD, and CAT in the liver and kidney 
      tissues while diminished MDA. Vit E also decreased ALT, BUN, and creatinine while 
      increased albumin. CONCLUSION: The results of this study showed that Vit E 
      prevented liver and renal tissue damage in hypothyroid rats.
CI  - Copyright: (c) 2023 Advanced Biomedical Research.
FAU - Hedayati-Moghadam, Mahdiyeh
AU  - Hedayati-Moghadam M
AD  - Department of Physiology, School of Medicine, Jiroft University of Medical 
      Sciences, Jiroft, Iran.
FAU - Baghcheghi, Yousef
AU  - Baghcheghi Y
AD  - Student Research Committee, Jiroft University of Medical Sciences, Jiroft, Iran.
FAU - Beheshti, Farimah
AU  - Beheshti F
AD  - Neuroscience Research Center, Torbat Heydariyeh University of Medical Sciences, 
      Torbat Heydariyeh, Iran.
AD  - Department of Physiology, School of Paramedical Sciences, Torbat Heydariyeh 
      University of Medical Sciences, Torbat Heydariyeh, Iran.
FAU - Shabgah, Arezoo G
AU  - Shabgah AG
AD  - School of Medicine, Bam University of Medical Sciences, Bam, Iran.
FAU - Salmani, Hossein
AU  - Salmani H
AD  - Student Research Committee, Jiroft University of Medical Sciences, Jiroft, Iran.
FAU - Hosseini, Mahmoud
AU  - Hosseini M
AD  - Psychiatry and Behavioral Sciences Research Center, Mashhad University of Medical 
      Sciences, Mashhad, Iran.
AD  - Applied Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.
LA  - eng
PT  - Journal Article
DEP - 20230328
PL  - India
TA  - Adv Biomed Res
JT  - Advanced biomedical research
JID - 101586897
PMC - PMC10186051
OTO - NOTNLM
OT  - Hypothyroidism
OT  - kidney
OT  - liver
OT  - vitamin E
COIS- There are no conflicts of interest.
EDAT- 2023/05/18 19:12
MHDA- 2023/05/18 19:13
PMCR- 2023/03/28
CRDT- 2023/05/18 16:45
PHST- 2021/08/30 00:00 [received]
PHST- 2022/08/09 00:00 [revised]
PHST- 2022/08/21 00:00 [accepted]
PHST- 2023/05/18 19:13 [medline]
PHST- 2023/05/18 19:12 [pubmed]
PHST- 2023/05/18 16:45 [entrez]
PHST- 2023/03/28 00:00 [pmc-release]
AID - ABR-12-75 [pii]
AID - 10.4103/abr.abr_275_21 [doi]
PST - epublish
SO  - Adv Biomed Res. 2023 Mar 28;12:75. doi: 10.4103/abr.abr_275_21. eCollection 2023.