PMID- 37205890
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20231031
IS  - 0972-0707 (Print)
IS  - 0974-5203 (Electronic)
IS  - 0972-0707 (Linking)
VI  - 26
IP  - 2
DP  - 2023 Mar-Apr
TI  - Regenerative biomineralization potential of commercially available remineralizing 
      agents as a preventive treatment approach for tooth erosion - An in vitro 
      laser-induced breakdown spectroscopy analysis.
PG  - 165-169
LID - 10.4103/jcd.jcd_483_22 [doi]
AB  - CONTEXT: In today's era, erosion is the most prevalent type of tooth wear. The 
      prevention of demineralization with biomineralization is the most desired 
      treatment. AIM: The aim of this study is to evaluate and compare the surface 
      remineralization potential of two remineralizing agents - self-assembling peptide 
      P11-4 (SAP P11-4) and calcium silicate plus sodium phosphate (CSSP) salts on 
      intact and demineralized enamel using laser-induced breakdown spectroscopy 
      (LIBS). SUBJECTS AND METHODS: Sixteen maxillary premolars were decoronated and 
      split into buccal and palatal halves embedded in acrylic resin with a total 
      sample size of 32 designated into Group 1 (intact teeth) and Group 2 
      (demineralized teeth). Further subdivision into Groups 1a and 2a (SAP P11-4 group 
      [n = 8]); Groups 1b and 2b (CSSP group [n = 8]), Group 2 was first exposed to 
      Coca-Cola. Then, all groups were subjected to experimental LIBS. Groups 1a and 2a 
      were treated with SAP P11-4 based product, i.e., CURODONT PROTECT gel. Groups 1b 
      and 2b were treated with CSSP-based products regimen, i.e., REGENERATE Enamel 
      Science Advanced Toothpaste and Advanced Enamel Serum. The LIBS assessment was 
      redone for all groups to attain a change in Ca and P values. STATISTICAL ANALYSIS 
      USED: Inferential statistics were done using Wilcoxon signed-rank test 
      (Before-After product application) and Mann-Whitney U-test (between the groups). 
      RESULTS: According to the statistical evaluation there was a statistically 
      significant difference (P < 0.05), in Ca and P values in demineralized teeth when 
      both SAP P11-4 and CSSP groups were evaluated. Although Ca values exhibited a 
      significant difference in intact teeth, P did not exhibit a significant 
      difference on the application of both remineralizing agents. The remineralizing 
      potential between the two agents, SAP P11-4 and CSSP groups. There was no 
      statistically significant difference ( P <0.05) observed between the two agent's 
      remineralization potential for intact and demineralized teeth. CONCLUSION: SAP 
      P11-4 and CSSP have the potential to remineralize both intact and demineralized 
      enamel. There was increased remineralization in demineralized samples subjected 
      to erosion.
CI  - Copyright: (c) 2023 Journal of Conservative Dentistry.
FAU - Moras, Carol Gloria
AU  - Moras CG
AD  - Department of Conservative Dentistry and Endodontics, Manipal College of Dental 
      Sciences, Manipal Academy of Higher Education, Manipal, Karnataka, India.
FAU - Acharya, Shashi Rashmi
AU  - Acharya SR
AD  - Department of Conservative Dentistry and Endodontics, Manipal College of Dental 
      Sciences, Manipal Academy of Higher Education, Manipal, Karnataka, India.
FAU - Adarsh, U K
AU  - Adarsh UK
AD  - Department of Atomic and Molecular Physics, Manipal Institute of Technology, 
      Manipal Academy of Higher Education, Manipal, Karnataka, India.
FAU - Unnikrishnan, V K
AU  - Unnikrishnan VK
AD  - Department of Atomic and Molecular Physics, Manipal Institute of Technology, 
      Manipal Academy of Higher Education, Manipal, Karnataka, India.
AD  - Centre of Excellence for Biophotonics, Manipal Academy of Higher Education, 
      Manipal, Karnataka, India.
LA  - eng
PT  - Journal Article
DEP - 20230316
PL  - India
TA  - J Conserv Dent
JT  - Journal of conservative dentistry : JCD
JID - 101147009
PMC - PMC10190084
OTO - NOTNLM
OT  - Calcium silicate
OT  - curodont
OT  - oligopeptide
OT  - tooth demineralization
OT  - tooth erosions
OT  - tooth remineralization
COIS- There are no conflicts of interest.
EDAT- 2023/05/19 19:14
MHDA- 2023/05/19 19:15
PMCR- 2023/03/01
CRDT- 2023/05/19 15:33
PHST- 2022/09/03 00:00 [received]
PHST- 2022/11/12 00:00 [revised]
PHST- 2022/11/28 00:00 [accepted]
PHST- 2023/05/19 19:15 [medline]
PHST- 2023/05/19 19:14 [pubmed]
PHST- 2023/05/19 15:33 [entrez]
PHST- 2023/03/01 00:00 [pmc-release]
AID - JCD-26-165 [pii]
AID - 10.4103/jcd.jcd_483_22 [doi]
PST - ppublish
SO  - J Conserv Dent. 2023 Mar-Apr;26(2):165-169. doi: 10.4103/jcd.jcd_483_22. Epub 
      2023 Mar 16.