PMID- 37206170
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20230522
IS  - 2222-3959 (Print)
IS  - 2227-4898 (Electronic)
IS  - 2222-3959 (Linking)
VI  - 16
IP  - 5
DP  - 2023
TI  - Analysis of retinal arteriolar and venular parameters in primary open angle 
      glaucoma.
PG  - 671-679
LID - 10.18240/ijo.2023.05.01 [doi]
AB  - AIM: To measure the retinal vessels of primary open angle glaucoma (POAG) 
      patients on spectral domain optical coherence tomography (SD-OCT) with a 
      full-width at half-maximum (FWHM) algorithm to better explore their structural 
      changes in the pathogenesis of POAG. METHODS: In this retrospective case-control 
      study, the right eyes of 32 patients with POAG and 30 healthy individuals were 
      routinely selected. Images of the supratemporal and infratemporal retinal vessels 
      in the B zones were obtained by SD-OCT, and the edges of the vessels were 
      identified by the FWHM method. The internal and external diameters, wall 
      thickness (WT), wall cross-sectional area (WCSA) and wall-to-lumen ratio (WLR) of 
      the blood vessels were studied. RESULTS: Compared with the healthy control group, 
      the POAG group showed a significantly reduced retinal arteriolar outer diameter 
      (RAOD), retinal arteriolar lumen diameter (RALD) and WSCA in the supratemporal 
      (124.22+/-12.42 vs 138.32+/-10.73 microm, 96.09+/-11.09 vs 108.53+/-9.89 microm, and 
      4762.02+/-913.51 vs 5785.75+/-1148.28 microm(2), respectively, all P<0.05) and 
      infratemporal regions (125.01+/-15.55 vs 141.57+/-10.77 microm, 96.27+/-13.29 vs 
      110.83+/-10.99 microm, and 4925.56+/-1302.88 vs 6087.78+/-1061.55 microm(2), all P<0.05). The 
      arteriolar WT and WLR were not significantly different between the POAG and 
      control groups, nor were the retinal venular outer diameter (RVOD), retinal 
      venular lumen diameter (RVLD) or venular WT in the supratemporal or infratemporal 
      region. There was a positive correlation between the arteriolar parameters and 
      visual function. CONCLUSION: In POAG, narrowing of the supratemporal and 
      infratemporal arterioles and a significant reduction in the WSCA is observed, 
      while the arteriolar WT and WLR do not change. Among the venular parameters, the 
      external diameter, internal diameter, WT, WLR, and WSCA of the venules are not 
      affected.
CI  - International Journal of Ophthalmology Press.
FAU - Wang, Jia-Peng
AU  - Wang JP
AD  - Zhejiang University School of Medicine, Hang Zhou 310030, Zhejiang Province, 
      China.
FAU - Yu, Mei-Ting
AU  - Yu MT
AD  - Quzhou Central Hospital of Zhejiang Chinese Medical University, Quzhou People's 
      Hospital, Quzhou 324000, Zhejiang Province, China.
FAU - Xu, Bo-Lun
AU  - Xu BL
AD  - Quzhou Central Hospital of Zhejiang Chinese Medical University, Quzhou People's 
      Hospital, Quzhou 324000, Zhejiang Province, China.
FAU - Hua, Jin-Ping
AU  - Hua JP
AD  - Quzhou Central Hospital of Zhejiang Chinese Medical University, Quzhou People's 
      Hospital, Quzhou 324000, Zhejiang Province, China.
FAU - Jiang, Li-Gang
AU  - Jiang LG
AD  - Quzhou Central Hospital of Zhejiang Chinese Medical University, Quzhou People's 
      Hospital, Quzhou 324000, Zhejiang Province, China.
FAU - Wang, Jian-Tao
AU  - Wang JT
AD  - Shenzhen Eye Hospital, Jinan University, Shenzhen 518040, Guangdong Province, 
      China.
FAU - Yang, Wei-Hua
AU  - Yang WH
AD  - Shenzhen Eye Hospital, Jinan University, Shenzhen 518040, Guangdong Province, 
      China.
FAU - Tong, Yu-Hua
AU  - Tong YH
AD  - Quzhou Central Hospital of Zhejiang Chinese Medical University, Quzhou People's 
      Hospital, Quzhou 324000, Zhejiang Province, China.
LA  - eng
PT  - Journal Article
DEP - 20230518
PL  - China
TA  - Int J Ophthalmol
JT  - International journal of ophthalmology
JID - 101553860
PMC - PMC10172105
OTO - NOTNLM
OT  - full-width at half-maximum algorithm
OT  - glaucoma
OT  - image segmentation
OT  - retinal vessels
OT  - vascular risk factors
EDAT- 2023/05/19 19:14
MHDA- 2023/05/19 19:15
PMCR- 2023/05/18
CRDT- 2023/05/19 15:37
PHST- 2023/03/01 00:00 [received]
PHST- 2023/03/20 00:00 [accepted]
PHST- 2023/05/19 19:15 [medline]
PHST- 2023/05/19 19:14 [pubmed]
PHST- 2023/05/19 15:37 [entrez]
PHST- 2023/05/18 00:00 [pmc-release]
AID - ijo-16-05-671 [pii]
AID - 10.18240/ijo.2023.05.01 [doi]
PST - epublish
SO  - Int J Ophthalmol. 2023 May 18;16(5):671-679. doi: 10.18240/ijo.2023.05.01. 
      eCollection 2023.