PMID- 37206178
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20230522
IS  - 2222-3959 (Print)
IS  - 2227-4898 (Electronic)
IS  - 2222-3959 (Linking)
VI  - 16
IP  - 5
DP  - 2023
TI  - Assessment of iris volume in glaucoma patients with type 2 diabetes mellitus by 
      AS-OCT.
PG  - 743-747
LID - 10.18240/ijo.2023.05.11 [doi]
AB  - AIM: To examine the change of iris volume measured by CASIA2 anterior segment 
      optical coherence tomography (AS-OCT) in glaucoma patients with or without type 2 
      diabetes mellitus (T2DM) and explore if there is a correlation between hemoglobin 
      A1c (HbA1c) level and iris volume. METHODS: In a cross-sectional study, 72 
      patients (115 eyes) were divided into two groups: primary open angle glaucoma 
      (POAG) group (55 eyes) and primary angle-closure glaucoma (PACG) group (60 eyes). 
      Patients in each group were separately classified into patients with or without 
      T2DM. Iris volume and glycosylated HbA1c level were measured and analyzed. 
      RESULTS: In the PACG group, diabetic patients' iris volume was significantly 
      lower than those of non-diabetics (P=0.02), and there was a significant 
      correlation between iris volume and HbA1c level in the PACG group (r=-0.26, 
      P=0.04). However, diabetic POAG patients' iris volume was noticeably higher than 
      those of non-diabetics (P=0.01), and there was a significant correlation between 
      HbA1c level and iris volume (r=0.32, P=0.02). CONCLUSION: Diabetes mellitus 
      impact iris volume size, as seen by increased iris volume in the POAG group and 
      decreased iris volume in the PACG group. In addition, iris volume is 
      significantly correlated with HbA1c level in glaucoma patients. These findings 
      imply that T2DM may compromise iris ultrastructure in glaucoma patients.
CI  - International Journal of Ophthalmology Press.
FAU - Su, Ying
AU  - Su Y
AD  - School of Clinical Medicine, Weifang Medical University, Weifang 261021, Shandong 
      Province, China.
AD  - Eye Institute of Shandong First Medical University, Qingdao Eye Hospital of 
      Shandong First Medical University, Qingdao 266071, Shandong Province, China.
AD  - State Key Laboratory Cultivation Base, Shandong Provincial Key Laboratory of 
      Ophthalmology, Qingdao 266071, Shandong Province, China.
AD  - School of Ophthalmology, Shandong First Medical University, Qingdao 266071, 
      Shandong Province, China.
FAU - Ge, Qing-Shu
AU  - Ge QS
AD  - Eye Institute of Shandong First Medical University, Qingdao Eye Hospital of 
      Shandong First Medical University, Qingdao 266071, Shandong Province, China.
AD  - State Key Laboratory Cultivation Base, Shandong Provincial Key Laboratory of 
      Ophthalmology, Qingdao 266071, Shandong Province, China.
AD  - School of Ophthalmology, Shandong First Medical University, Qingdao 266071, 
      Shandong Province, China.
FAU - Li, Zong-Yi
AU  - Li ZY
AD  - Eye Institute of Shandong First Medical University, Qingdao Eye Hospital of 
      Shandong First Medical University, Qingdao 266071, Shandong Province, China.
AD  - State Key Laboratory Cultivation Base, Shandong Provincial Key Laboratory of 
      Ophthalmology, Qingdao 266071, Shandong Province, China.
AD  - School of Ophthalmology, Shandong First Medical University, Qingdao 266071, 
      Shandong Province, China.
FAU - Bu, Qian-Wen
AU  - Bu QW
AD  - Eye Institute of Shandong First Medical University, Qingdao Eye Hospital of 
      Shandong First Medical University, Qingdao 266071, Shandong Province, China.
AD  - State Key Laboratory Cultivation Base, Shandong Provincial Key Laboratory of 
      Ophthalmology, Qingdao 266071, Shandong Province, China.
AD  - School of Ophthalmology, Shandong First Medical University, Qingdao 266071, 
      Shandong Province, China.
FAU - Hu, Die
AU  - Hu D
AD  - Eye Institute of Shandong First Medical University, Qingdao Eye Hospital of 
      Shandong First Medical University, Qingdao 266071, Shandong Province, China.
AD  - State Key Laboratory Cultivation Base, Shandong Provincial Key Laboratory of 
      Ophthalmology, Qingdao 266071, Shandong Province, China.
AD  - School of Ophthalmology, Shandong First Medical University, Qingdao 266071, 
      Shandong Province, China.
FAU - Zhou, Long-Fang
AU  - Zhou LF
AD  - Eye Institute of Shandong First Medical University, Qingdao Eye Hospital of 
      Shandong First Medical University, Qingdao 266071, Shandong Province, China.
AD  - State Key Laboratory Cultivation Base, Shandong Provincial Key Laboratory of 
      Ophthalmology, Qingdao 266071, Shandong Province, China.
AD  - School of Ophthalmology, Shandong First Medical University, Qingdao 266071, 
      Shandong Province, China.
FAU - Pan, Xiao-Jing
AU  - Pan XJ
AD  - Eye Institute of Shandong First Medical University, Qingdao Eye Hospital of 
      Shandong First Medical University, Qingdao 266071, Shandong Province, China.
AD  - State Key Laboratory Cultivation Base, Shandong Provincial Key Laboratory of 
      Ophthalmology, Qingdao 266071, Shandong Province, China.
AD  - School of Ophthalmology, Shandong First Medical University, Qingdao 266071, 
      Shandong Province, China.
LA  - eng
PT  - Journal Article
DEP - 20230518
PL  - China
TA  - Int J Ophthalmol
JT  - International journal of ophthalmology
JID - 101553860
PMC - PMC10172094
OTO - NOTNLM
OT  - diabetes mellitus
OT  - glaucoma
OT  - glycosylated hemoglobin
OT  - iris volume
OT  - optical coherence tomography
EDAT- 2023/05/19 19:14
MHDA- 2023/05/19 19:15
PMCR- 2023/05/18
CRDT- 2023/05/19 15:37
PHST- 2023/02/16 00:00 [received]
PHST- 2023/03/06 00:00 [accepted]
PHST- 2023/05/19 19:15 [medline]
PHST- 2023/05/19 19:14 [pubmed]
PHST- 2023/05/19 15:37 [entrez]
PHST- 2023/05/18 00:00 [pmc-release]
AID - ijo-16-05-743 [pii]
AID - 10.18240/ijo.2023.05.11 [doi]
PST - epublish
SO  - Int J Ophthalmol. 2023 May 18;16(5):743-747. doi: 10.18240/ijo.2023.05.11. 
      eCollection 2023.