PMID- 37206286
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20230522
IS  - 2688-6146 (Electronic)
IS  - 2688-6146 (Linking)
VI  - 4
IP  - 2
DP  - 2023 May
TI  - Refining eligibility criteria of unit selection for myeloablative cord blood 
      transplantation in acute leukemia: Real-world experience of a referral center.
PG  - 470-475
LID - 10.1002/jha2.703 [doi]
AB  - The algorithm for cord blood (CB) unit selection is still somewhat ambiguous. We 
      retrospectively analyzed 620 cases of acute leukemia between 2015 and 2020, who 
      were treated with myeloablative single-unit umbilical CB transplantation (UCBT). 
      We found that, when human leukocyte antigen (HLA) mismatch was </=3/10, CD34(+) 
      cell dosage <0.83 x 10(5)/kg-considerably lower than prevalent guidelines-was 
      permissible without affecting survival. Moreover, synergy between donor 
      killer-cell immunoglobulin-like receptors (KIR) haplotypes-B and donor-recipient 
      HLA-C mismatch protected against relapse-related mortality. We submit that 
      minimum required CD34(+) cell dosage can possibly be relaxed to broaden access to 
      UCBT, and donor KIR genotyping should be considered during unit selection.
CI  - (c) 2023 The Authors. eJHaem published by British Society for Haematology and John 
      Wiley & Sons Ltd.
FAU - Sun, Zimin
AU  - Sun Z
AUID- ORCID: 0000-0002-4541-1845
AD  - Department of Hematology The First Affiliated Hospital of University of Science 
      and Technology of China Hefei China.
AD  - Blood and Cell Therapy Institute Division of Life Sciences and Medicine Anhui 
      Provincial Key Laboratory of Blood Research and Applications University of 
      Science and Technology of China Hefei China.
FAU - Hu, Yu
AU  - Hu Y
AD  - State Key Laboratory of Experimental Hematology National Clinical Research Center 
      for Blood Diseases Haihe Laboratory of Cell Ecosystem Institute of Hematology and 
      Blood Diseases Hospital Chinese Academy of Medical Sciences and Peking Union 
      Medical College Tianjin China.
AD  - Tianjin Institutes of Health Science Tianjin China.
FAU - Ji, Yanping
AU  - Ji Y
AUID- ORCID: 0000-0003-4342-8464
AD  - School of Clinical Medicine Anhui Medical University Hefei China.
AD  - Department of Hematology Affiliated Hospital of Jiangsu University Zhenjiang 
      China.
FAU - Liu, Xueou
AU  - Liu X
AD  - State Key Laboratory of Experimental Hematology National Clinical Research Center 
      for Blood Diseases Haihe Laboratory of Cell Ecosystem Institute of Hematology and 
      Blood Diseases Hospital Chinese Academy of Medical Sciences and Peking Union 
      Medical College Tianjin China.
AD  - Tianjin Institutes of Health Science Tianjin China.
FAU - Gong, Xiaowen
AU  - Gong X
AD  - State Key Laboratory of Experimental Hematology National Clinical Research Center 
      for Blood Diseases Haihe Laboratory of Cell Ecosystem Institute of Hematology and 
      Blood Diseases Hospital Chinese Academy of Medical Sciences and Peking Union 
      Medical College Tianjin China.
AD  - Tianjin Institutes of Health Science Tianjin China.
FAU - Feng, Yahui
AU  - Feng Y
AD  - State Key Laboratory of Experimental Hematology National Clinical Research Center 
      for Blood Diseases Haihe Laboratory of Cell Ecosystem Institute of Hematology and 
      Blood Diseases Hospital Chinese Academy of Medical Sciences and Peking Union 
      Medical College Tianjin China.
AD  - Tianjin Institutes of Health Science Tianjin China.
FAU - Liu, Huilan
AU  - Liu H
AD  - Department of Hematology The First Affiliated Hospital of University of Science 
      and Technology of China Hefei China.
AD  - Blood and Cell Therapy Institute Division of Life Sciences and Medicine Anhui 
      Provincial Key Laboratory of Blood Research and Applications University of 
      Science and Technology of China Hefei China.
FAU - Zhang, Wei
AU  - Zhang W
AD  - State Key Laboratory of Experimental Hematology National Clinical Research Center 
      for Blood Diseases Haihe Laboratory of Cell Ecosystem Institute of Hematology and 
      Blood Diseases Hospital Chinese Academy of Medical Sciences and Peking Union 
      Medical College Tianjin China.
AD  - Tianjin Institutes of Health Science Tianjin China.
FAU - Qi, Saibing
AU  - Qi S
AD  - State Key Laboratory of Experimental Hematology National Clinical Research Center 
      for Blood Diseases Haihe Laboratory of Cell Ecosystem Institute of Hematology and 
      Blood Diseases Hospital Chinese Academy of Medical Sciences and Peking Union 
      Medical College Tianjin China.
AD  - Tianjin Institutes of Health Science Tianjin China.
FAU - Shen, Qiujin
AU  - Shen Q
AD  - State Key Laboratory of Experimental Hematology National Clinical Research Center 
      for Blood Diseases Haihe Laboratory of Cell Ecosystem Institute of Hematology and 
      Blood Diseases Hospital Chinese Academy of Medical Sciences and Peking Union 
      Medical College Tianjin China.
AD  - Tianjin Institutes of Health Science Tianjin China.
FAU - Song, Kaidi
AU  - Song K
AD  - Department of Hematology The First Affiliated Hospital of University of Science 
      and Technology of China Hefei China.
AD  - Blood and Cell Therapy Institute Division of Life Sciences and Medicine Anhui 
      Provincial Key Laboratory of Blood Research and Applications University of 
      Science and Technology of China Hefei China.
FAU - Geng, Liangquan
AU  - Geng L
AD  - Department of Hematology The First Affiliated Hospital of University of Science 
      and Technology of China Hefei China.
AD  - Blood and Cell Therapy Institute Division of Life Sciences and Medicine Anhui 
      Provincial Key Laboratory of Blood Research and Applications University of 
      Science and Technology of China Hefei China.
FAU - Yao, Wen
AU  - Yao W
AD  - Department of Hematology The First Affiliated Hospital of University of Science 
      and Technology of China Hefei China.
AD  - Blood and Cell Therapy Institute Division of Life Sciences and Medicine Anhui 
      Provincial Key Laboratory of Blood Research and Applications University of 
      Science and Technology of China Hefei China.
FAU - Wan, Xiang
AU  - Wan X
AD  - Department of Hematology The First Affiliated Hospital of University of Science 
      and Technology of China Hefei China.
AD  - Blood and Cell Therapy Institute Division of Life Sciences and Medicine Anhui 
      Provincial Key Laboratory of Blood Research and Applications University of 
      Science and Technology of China Hefei China.
FAU - Tang, Baolin
AU  - Tang B
AD  - Department of Hematology The First Affiliated Hospital of University of Science 
      and Technology of China Hefei China.
AD  - Blood and Cell Therapy Institute Division of Life Sciences and Medicine Anhui 
      Provincial Key Laboratory of Blood Research and Applications University of 
      Science and Technology of China Hefei China.
FAU - Zhu, Xiaoyu
AU  - Zhu X
AD  - Department of Hematology The First Affiliated Hospital of University of Science 
      and Technology of China Hefei China.
AD  - Blood and Cell Therapy Institute Division of Life Sciences and Medicine Anhui 
      Provincial Key Laboratory of Blood Research and Applications University of 
      Science and Technology of China Hefei China.
FAU - Sun, Guangyu
AU  - Sun G
AD  - Department of Hematology The First Affiliated Hospital of University of Science 
      and Technology of China Hefei China.
AD  - Blood and Cell Therapy Institute Division of Life Sciences and Medicine Anhui 
      Provincial Key Laboratory of Blood Research and Applications University of 
      Science and Technology of China Hefei China.
FAU - Qiang, Ping
AU  - Qiang P
AUID- ORCID: 0000-0003-0857-7843
AD  - Department of Hematology The First Affiliated Hospital of University of Science 
      and Technology of China Hefei China.
AD  - Blood and Cell Therapy Institute Division of Life Sciences and Medicine Anhui 
      Provincial Key Laboratory of Blood Research and Applications University of 
      Science and Technology of China Hefei China.
FAU - Song, Zhen
AU  - Song Z
AD  - State Key Laboratory of Experimental Hematology National Clinical Research Center 
      for Blood Diseases Haihe Laboratory of Cell Ecosystem Institute of Hematology and 
      Blood Diseases Hospital Chinese Academy of Medical Sciences and Peking Union 
      Medical College Tianjin China.
AD  - Tianjin Institutes of Health Science Tianjin China.
FAU - Chen, Junren
AU  - Chen J
AUID- ORCID: 0000-0003-3691-4931
AD  - State Key Laboratory of Experimental Hematology National Clinical Research Center 
      for Blood Diseases Haihe Laboratory of Cell Ecosystem Institute of Hematology and 
      Blood Diseases Hospital Chinese Academy of Medical Sciences and Peking Union 
      Medical College Tianjin China.
AD  - Tianjin Institutes of Health Science Tianjin China.
LA  - eng
PT  - Journal Article
DEP - 20230425
PL  - United States
TA  - EJHaem
JT  - EJHaem
JID - 101761942
PMC - PMC10188464
OTO - NOTNLM
OT  - alternative donors
OT  - umbilical cord blood transplantation
COIS- The authors declare that there is no conflict of interest that could be perceived 
      as prejudicing the impartiality of the research reported.
EDAT- 2023/05/19 19:14
MHDA- 2023/05/19 19:15
PMCR- 2023/04/25
CRDT- 2023/05/19 15:38
PHST- 2023/04/04 00:00 [received]
PHST- 2023/04/14 00:00 [revised]
PHST- 2023/04/18 00:00 [accepted]
PHST- 2023/05/19 19:15 [medline]
PHST- 2023/05/19 19:14 [pubmed]
PHST- 2023/05/19 15:38 [entrez]
PHST- 2023/04/25 00:00 [pmc-release]
AID - JHA2703 [pii]
AID - 10.1002/jha2.703 [doi]
PST - epublish
SO  - EJHaem. 2023 Apr 25;4(2):470-475. doi: 10.1002/jha2.703. eCollection 2023 May.