PMID- 37206552
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20230522
IS  - 1792-1015 (Electronic)
IS  - 1792-0981 (Print)
IS  - 1792-0981 (Linking)
VI  - 25
IP  - 6
DP  - 2023 Jun
TI  - Changes in the balance of Th17/Treg cells and oxidative stress markers in 
      patients with HIV‑associated pulmonary tuberculosis who develop IRIS.
PG  - 271
LID - 10.3892/etm.2023.11970 [doi]
LID - 271
AB  - Tuberculosis (TB) is the most common opportunistic infection in patients with 
      acquired immunodeficiency syndrome (AIDS) caused by human immunodeficiency virus 
      (HIV) infection and is one of the primary causes of death from AIDS. The 
      increased accessibility to highly active antiretroviral therapy (HAART) has 
      significantly improved the clinical outcome of patients with HIV infection. 
      However, following ART, rapid restoration of the immune system leads to immune 
      reconstitution inflammatory syndrome (IRIS). Oxidative stress and innate immunity 
      play a role in TB-associated IRIS (TB-IRIS). The present study investigated the 
      changes that occur in oxidative stress markers and T helper (Th)17/regulatory T 
      (Treg) cell balance and their significance in IRIS patients with HIV-associated 
      pulmonary TB. A total of 316 patients with HIV-associated pulmonary TB were 
      treated with HAART and followed up regularly for 12 weeks. Those who developed 
      IRIS were included in the IRIS group (n=60), while the remaining patients were 
      included in the non-IRIS group (n=256). The changes in plasma oxidative stress 
      markers superoxide dismutase (SOD) and malondialdehyde (MDA) were detected with 
      the ELISA, and the ratio of Th17 to Treg cells in whole blood were analyzed 
      before and after treatment through the flow cytometric assay. Following 
      treatment, MDA and Th17 cells levels were significantly increased while SOD and 
      Treg cells levels were decreased in the IRIS group (P<0.05) compared with before 
      treatment. In the non-IRIS group, a non-significant decrease was observed in SOD 
      levels (P>0.05), while the MDA levels significantly decreased compared with 
      before treatment (P<0.05) and the Th17 and Treg cells levels were both 
      significantly increased (P<0.05). After treatment, compared with the non-IRIS 
      group, the IRIS group showed a significant increase in MDA and Th17 cells and 
      decrease in SOD and Treg cells levels (P<0.05). In addition, Th17 cells levels 
      were positively correlated with MDA but negatively correlated with SOD levels. 
      Treg levels were negatively correlated with MDA and positively correlated with 
      SOD levels (P<0.05). The area under the curve values of serum MDA and SOD, Th17 
      and Treg levels predicting the occurrence of IRIS were 0.738, 0.883, 0.722 and 
      0.719, respectively (P<0.05). These results indicated that the above parameters 
      have certain diagnostic value for the occurrence of IRIS. The occurrence of IRIS 
      in patients with HIV-associated pulmonary TB may be associated with oxidative 
      stress and Th17/Treg cell imbalance.
CI  - Copyright: (c) Wen et al.
FAU - Wen, Long
AU  - Wen L
AD  - Department of Respiratory and Critical Care Medicine, The Affiliated Changsha 
      Hospital of Xiangya School of Medicine, Central South University, The First 
      Hospital of Changsha, Changsha, Hunan 410000, P.R. China.
FAU - Shi, Lei
AU  - Shi L
AD  - Department of Nursing, The Fourth Hospital of Changsha, Changsha, Hunan 410000, 
      P.R. China.
FAU - Wan, Shan-Shan
AU  - Wan SS
AD  - Department of Respiratory and Critical Care Medicine, The Affiliated Changsha 
      Hospital of Xiangya School of Medicine, Central South University, The First 
      Hospital of Changsha, Changsha, Hunan 410000, P.R. China.
FAU - Xu, Tao
AU  - Xu T
AD  - Department of Respiratory and Critical Care Medicine, The Affiliated Changsha 
      Hospital of Xiangya School of Medicine, Central South University, The First 
      Hospital of Changsha, Changsha, Hunan 410000, P.R. China.
FAU - Zhang, Lei
AU  - Zhang L
AD  - Department of Respiratory Medicine, Yicheng People's Hospital of Shandong, 
      Zaozhuang, Shandong 277300, P.R. China.
FAU - Zhou, Zhi-Guo
AU  - Zhou ZG
AD  - Department of Respiratory and Critical Care Medicine, The Affiliated Changsha 
      Hospital of Xiangya School of Medicine, Central South University, The First 
      Hospital of Changsha, Changsha, Hunan 410000, P.R. China.
LA  - eng
PT  - Journal Article
DEP - 20230421
PL  - Greece
TA  - Exp Ther Med
JT  - Experimental and therapeutic medicine
JID - 101531947
PMC - PMC10189753
OTO - NOTNLM
OT  - T helper cell 17
OT  - immune reconstitution inflammatory syndrome
OT  - oxidative stress
OT  - regulatory T cell
COIS- The authors declare that they have no competing interests.
EDAT- 2023/05/19 19:15
MHDA- 2023/05/19 19:16
PMCR- 2023/04/21
CRDT- 2023/05/19 15:42
PHST- 2022/07/01 00:00 [received]
PHST- 2023/02/23 00:00 [accepted]
PHST- 2023/05/19 19:16 [medline]
PHST- 2023/05/19 19:15 [pubmed]
PHST- 2023/05/19 15:42 [entrez]
PHST- 2023/04/21 00:00 [pmc-release]
AID - ETM-25-6-11970 [pii]
AID - 10.3892/etm.2023.11970 [doi]
PST - epublish
SO  - Exp Ther Med. 2023 Apr 21;25(6):271. doi: 10.3892/etm.2023.11970. eCollection 
      2023 Jun.