PMID- 37206602
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20230522
IS  - 2691-171X (Electronic)
IS  - 2691-171X (Linking)
VI  - 1
IP  - 2
DP  - 2020 Nov
TI  - Chronic Recurrent Multifocal Osteomyelitis in Pediatric Crohn Disease, A 
      Paradoxical Effect to Antitumor Necrosis Factor Alpha.
PG  - e007
LID - 10.1097/PG9.0000000000000007 [doi]
AB  - Tumor necrosis factor-alpha (TNF-alpha) inhibitors have resulted in significant progress 
      in the treatment of chronic inflammatory diseases. However, these therapies can 
      lead to paradoxical immune-mediated inflammatory diseases with unknown 
      physiopathology. For the first time, we report 3 cases of paradoxical chronic 
      recurrent multifocal osteomyelitis after infliximab or adalimumab therapy during 
      the course of Crohn disease. The patients complained of bone pain without joint 
      involvement. At the time of diagnosis of paradoxical reaction, all patients were 
      in remission due to anti-TNFalpha efficiency. Trough levels of anti-TNFalpha were in the 
      expected range, and there were no anti-anti-TNFalpha antibodies. The duration of 
      treatment was between 2 and 26 months. Other causes of CRMO were excluded. All 
      patients recovered after discontinuation of infliximab (n = 2) or adalimumab (n = 
      1). The increasing use of these therapies leads to new descriptions of 
      paradoxical effects, which clinicians should be aware of.
CI  - Copyright (c) 2020 The Author(s). Published by Wolters Kluwer on behalf of European 
      Society for Pediatric Gastroenterology, Hepatology, and Nutrition and North 
      American Society for Pediatric Gastroenterology, Hepatology, and Nutrition.
FAU - Cordesse, Anne
AU  - Cordesse A
AD  - From the Service de Nutrition et Gastroenterologie Pediatriques, APHP, Hopital 
      Trousseau, France.
FAU - Ecochard-Dugelay, Emmanuelle
AU  - Ecochard-Dugelay E
AD  - Service de Gastroenterologie et Nutrition Pediatriques, APHP, Hopital Robert 
      Debre, France.
FAU - Melki, Isabelle
AU  - Melki I
AD  - Service de pediatrie generale, maladies infectieuses et medecine interne 
      pediatrique, APHP, Hopital Robert Debre, France.
FAU - Caseris, Marion
AU  - Caseris M
AD  - Service de pediatrie generale, maladies infectieuses et medecine interne 
      pediatrique, APHP, Hopital Robert Debre, France.
FAU - Belarbi, Nadia
AU  - Belarbi N
AD  - Service d'imagerie pediatrique et foetale, APHP, Hopital Robert Debre, France.
FAU - Hugot, Jean-Pierre
AU  - Hugot JP
AD  - Service de Gastroenterologie et Nutrition Pediatriques, APHP, Hopital Robert 
      Debre, France.
AD  - Universite Paris Diderot, Paris, France.
AD  - INSERM UMR 1123 (ECEVE), Paris, France.
FAU - Viala, Jerome
AU  - Viala J
AD  - Service de Gastroenterologie et Nutrition Pediatriques, APHP, Hopital Robert 
      Debre, France.
AD  - Universite Paris Diderot, Paris, France.
AD  - INSERM UMR 1123 (ECEVE), Paris, France.
FAU - Martinez-Vinson, Christine
AU  - Martinez-Vinson C
AD  - Service de Gastroenterologie et Nutrition Pediatriques, APHP, Hopital Robert 
      Debre, France.
LA  - eng
PT  - Case Reports
DEP - 20200820
PL  - United States
TA  - JPGN Rep
JT  - JPGN reports
JID - 101773885
PMC - PMC10191537
OTO - NOTNLM
OT  - Crohn disease
OT  - anti-TNF-alpha
OT  - chronic recurrent multifocal osteomyelitis
OT  - paradoxical effect
COIS- Disclosure: C.M.V. received honoraria, speaker's fees, and/or congress fees from 
      AbbVie, MSD, Nestle, Biogen, Adacyte. J.P.H. received congress fees from MSD, 
      Biogen. The remaining authors report no conflicts of interest.
EDAT- 2020/08/20 00:00
MHDA- 2020/08/20 00:01
PMCR- 2020/08/20
CRDT- 2023/05/19 15:43
PHST- 2020/06/24 00:00 [received]
PHST- 2020/07/30 00:00 [accepted]
PHST- 2020/08/20 00:01 [medline]
PHST- 2020/08/20 00:00 [pubmed]
PHST- 2023/05/19 15:43 [entrez]
PHST- 2020/08/20 00:00 [pmc-release]
AID - 10.1097/PG9.0000000000000007 [doi]
PST - epublish
SO  - JPGN Rep. 2020 Aug 20;1(2):e007. doi: 10.1097/PG9.0000000000000007. eCollection 
      2020 Nov.