PMID- 37207138
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20230522
IS  - 2234-943X (Print)
IS  - 2234-943X (Electronic)
IS  - 2234-943X (Linking)
VI  - 13
DP  - 2023
TI  - Isolated splenic metastasis from primary fallopian tube carcinoma and the 
      application of laparoscopic splenectomy: a case report and literature review.
PG  - 1079044
LID - 10.3389/fonc.2023.1079044 [doi]
LID - 1079044
AB  - Metastases to the spleen from various non-hematologic malignancies are generally 
      not a common clinical event and usually indicate the late dissemination of 
      disease. Solitary splenic metastases from solid neoplasm are extremely uncommon. 
      Furthermore, solitary metastasis to the spleen from primary fallopian tube 
      carcinoma (PFTC) is extremely rare and has not been reported previously. We 
      report a case of isolated splenic metastasis in a 60-year-old woman, occurring 13 
      months after a total hysterectomy, a bilateral salpingo-oophorectomy, a pelvic 
      lymphadenectomy, a para-aortic lymphadenectomy, an omentectomy, and an 
      appendectomy were performed for PFTC. The patient's serum tumor marker CA125 was 
      elevated to 49.25 U/ml (N < 35.0 U/ml). An abdominal computed tomography (CT) 
      scan revealed a 4.0 x 3.0 cm low-density lesion in the spleen that was 
      potentially malignant, with no lymphadenectasis or distant metastasis. The 
      patient underwent a laparoscopic exploration, and one lesion was found in the 
      spleen. Then, a laparoscopic splenectomy (LS) confirmed a splenic metastasis from 
      PFTC. The histopathological diagnosis showed that the splenic lesion was a 
      high-differentiated serous carcinoma from PFTC metastasis. The patient recovered 
      for over 1 year, with no tumor recurrence. This is the first reported case of an 
      isolated splenic metastasis from PFTC. This case underlines the importance of 
      serum tumor marker assessment, medical imaging examination, and history of 
      malignancy during follow-up, and LS seems to be the optimal approach for isolated 
      splenic metastasis from PFTC.
CI  - Copyright (c) 2023 Kang, Zhao, Jiang and Li.
FAU - Kang, Dongxue
AU  - Kang D
AD  - Department of Operating Room, The Fourth Affiliated Hospital of China Medical 
      University, Shenyang, China.
FAU - Zhao, Danyang
AU  - Zhao D
AD  - Department of Emergency, The Fourth Affiliated Hospital of China Medical 
      University, Shenyang, China.
FAU - Jiang, Xiaodi
AU  - Jiang X
AD  - Department of Infectious Diseases, Shengjing Hospital of China Medical 
      University, Shenyang, China.
FAU - Li, Deming
AU  - Li D
AD  - Department of Anesthesiology, The Fourth Affiliated Hospital of China Medical 
      University, Shenyang, China.
LA  - eng
PT  - Case Reports
DEP - 20230503
PL  - Switzerland
TA  - Front Oncol
JT  - Frontiers in oncology
JID - 101568867
PMC - PMC10189115
OTO - NOTNLM
OT  - bilateral salpingo-oophorectomy
OT  - laparoscopic splenectomy
OT  - primary fallopian tube carcinoma
OT  - splenic metastasis
OT  - total hysterectomy
COIS- The authors declare that the research was conducted in the absence of any 
      commercial or financial relationships that could be construed as a potential 
      conflict of interest.
EDAT- 2023/05/19 19:14
MHDA- 2023/05/19 19:15
PMCR- 2023/01/01
CRDT- 2023/05/19 15:52
PHST- 2022/11/10 00:00 [received]
PHST- 2023/04/11 00:00 [accepted]
PHST- 2023/05/19 19:15 [medline]
PHST- 2023/05/19 19:14 [pubmed]
PHST- 2023/05/19 15:52 [entrez]
PHST- 2023/01/01 00:00 [pmc-release]
AID - 10.3389/fonc.2023.1079044 [doi]
PST - epublish
SO  - Front Oncol. 2023 May 3;13:1079044. doi: 10.3389/fonc.2023.1079044. eCollection 
      2023.