PMID- 37210847
OWN - NLM
STAT- MEDLINE
DCOM- 20230619
LR  - 20231116
IS  - 1618-131X (Electronic)
IS  - 1438-4639 (Linking)
VI  - 251
DP  - 2023 Jun
TI  - Sex-specific effect of perfluoroalkyl substances exposure on liver and thyroid 
      function biomarkers: A mixture approach.
PG  - 114189
LID - S1438-4639(23)00080-9 [pii]
LID - 10.1016/j.ijheh.2023.114189 [doi]
AB  - Although studies have investigated the effects of perfluoroalkyl substances 
      (PFASs) on liver and thyroid function, little is known about its combined and 
      sex-specific effect. A total of 688 participants were interviewed and serum PFASs 
      concentration was measured using liquid chromatography/mass spectrometry. Five 
      biomarkers of liver and thyroid function (ALT, GGT, TSH, FT3 and FT4) were chosen 
      as outcomes. A restriction cubic spline function was applied to capture the 
      dose-response relationship between PFASs and liver enzymes and thyroid hormones. 
      Multivariable regression and Bayesian kernel machine regression (BKMR) models 
      were performed to assess the single and overall associations of PFASs with 
      targeted biomarkers. Single-pollutant analyses indicated that increased PFASs 
      concentrations were associated with elevated ALT and GGT levels. BKMR models 
      suggested positive dose-response relationships between PFASs mixtures and ALT and 
      GGT levels. Significant associations were only detected between several PFASs and 
      thyroid hormones, and joint effect of PFASs mixtures on FT3 levels was found at 
      higher concentrations. Meanwhile, sex differences were found in the associations 
      of PFASs with ALT and GGT levels, with significant results only in males. Our 
      findings provide epidemiological evidence for combined and sex-specific effects 
      of PFASs on ALT and GGT levels.
CI  - Copyright (c) 2023 Elsevier GmbH. All rights reserved.
FAU - Yang, Ze
AU  - Yang Z
AD  - Department of Occupational and Environmental Health, School of Public Health, 
      Tianjin Medical University, Tianjin, 300070, China; Tianjin Key Laboratory of 
      Environment, Nutrition, and Public Health, Tianjin Medical University, Tianjin, 
      300070, China; Center for International Collaborative Research on Environment, 
      Nutrition and Public Health, Tianjin, 300070, China.
FAU - Liu, Ruifang
AU  - Liu R
AD  - Department of Occupational and Environmental Health, School of Public Health, 
      Tianjin Medical University, Tianjin, 300070, China; Tianjin Key Laboratory of 
      Environment, Nutrition, and Public Health, Tianjin Medical University, Tianjin, 
      300070, China; Center for International Collaborative Research on Environment, 
      Nutrition and Public Health, Tianjin, 300070, China.
FAU - Liu, Hongbo
AU  - Liu H
AD  - Department of Occupational and Environmental Health, School of Public Health, 
      Tianjin Medical University, Tianjin, 300070, China; Tianjin Key Laboratory of 
      Environment, Nutrition, and Public Health, Tianjin Medical University, Tianjin, 
      300070, China; Center for International Collaborative Research on Environment, 
      Nutrition and Public Health, Tianjin, 300070, China.
FAU - Wei, Jiemin
AU  - Wei J
AD  - Department of Occupational and Environmental Health, School of Public Health, 
      Tianjin Medical University, Tianjin, 300070, China; Tianjin Key Laboratory of 
      Environment, Nutrition, and Public Health, Tianjin Medical University, Tianjin, 
      300070, China; Center for International Collaborative Research on Environment, 
      Nutrition and Public Health, Tianjin, 300070, China.
FAU - Lin, Xiaohui
AU  - Lin X
AD  - Sanitary Inspection Institute, Tianjin Centers for Disease Control and 
      Prevention, Tianjin, 300171, China.
FAU - Zhang, Mingyue
AU  - Zhang M
AD  - Sanitary Inspection Institute, Tianjin Centers for Disease Control and 
      Prevention, Tianjin, 300171, China.
FAU - Chen, Yu
AU  - Chen Y
AD  - Department of Endocrinology, The Second Hospital of Tianjin Medical University, 
      Tianjin, 300202, China.
FAU - Zhang, Jingyun
AU  - Zhang J
AD  - NHC Key Laboratory of Hormones and Development, Tianjin Key Laboratory of 
      Metabolic Diseases, Chu Hsien-I Memorial Hospital & Tianjin Institute of 
      Endocrinology, Tianjin Medical University, Tianjin, 300134, China.
FAU - Sun, Meiqing
AU  - Sun M
AD  - Wuqing District Center for Disease Control and Prevention, Tianjin, 301700, 
      China.
FAU - Feng, Zhe
AU  - Feng Z
AD  - Wuqing District Center for Disease Control and Prevention, Tianjin, 301700, 
      China.
FAU - Liu, Jian
AU  - Liu J
AD  - Wuqing District Center for Disease Control and Prevention, Tianjin, 301700, 
      China.
FAU - Liu, Xiangyang
AU  - Liu X
AD  - NHC Key Laboratory of Hormones and Development, Tianjin Key Laboratory of 
      Metabolic Diseases, Chu Hsien-I Memorial Hospital & Tianjin Institute of 
      Endocrinology, Tianjin Medical University, Tianjin, 300134, China.
FAU - Huo, Xiaoxu
AU  - Huo X
AD  - Department of Epidemiology and Biostatistics, School of Public Health, Tianjin 
      Medical University, Tianjin, 300070, China.
FAU - Men, Kun
AU  - Men K
AD  - Department of Laboratory, The Second Hospital of Tianjin Medical University, 
      Tianjin, 300202, China.
FAU - Yang, Qiaoyun
AU  - Yang Q
AD  - Department of Occupational and Environmental Health, School of Public Health, 
      Tianjin Medical University, Tianjin, 300070, China; Tianjin Key Laboratory of 
      Environment, Nutrition, and Public Health, Tianjin Medical University, Tianjin, 
      300070, China; Center for International Collaborative Research on Environment, 
      Nutrition and Public Health, Tianjin, 300070, China.
FAU - Chen, Xi
AU  - Chen X
AD  - Department of Occupational and Environmental Health, School of Public Health, 
      Tianjin Medical University, Tianjin, 300070, China; Tianjin Key Laboratory of 
      Environment, Nutrition, and Public Health, Tianjin Medical University, Tianjin, 
      300070, China; Center for International Collaborative Research on Environment, 
      Nutrition and Public Health, Tianjin, 300070, China.
FAU - Tang, Nai-Jun
AU  - Tang NJ
AD  - Department of Occupational and Environmental Health, School of Public Health, 
      Tianjin Medical University, Tianjin, 300070, China; Tianjin Key Laboratory of 
      Environment, Nutrition, and Public Health, Tianjin Medical University, Tianjin, 
      300070, China; Center for International Collaborative Research on Environment, 
      Nutrition and Public Health, Tianjin, 300070, China. Electronic address: 
      tangnaijun@tmu.edu.cn.
LA  - eng
PT  - Journal Article
DEP - 20230519
PL  - Germany
TA  - Int J Hyg Environ Health
JT  - International journal of hygiene and environmental health
JID - 100898843
RN  - 0 (Fluorocarbons)
RN  - 0 (Thyroid Hormones)
RN  - 0 (Biomarkers)
SB  - IM
MH  - Humans
MH  - Male
MH  - Female
MH  - *Thyroid Gland
MH  - Bayes Theorem
MH  - *Fluorocarbons
MH  - Thyroid Hormones
MH  - Liver
MH  - Biomarkers
OTO - NOTNLM
OT  - Liver function
OT  - Mixture
OT  - Perfluoroalkyl substances
OT  - Sex-specific effect
OT  - Thyroid function
COIS- Declaration of competing interest Authors declare no actual or potential 
      competing financial interests.
EDAT- 2023/05/22 00:41
MHDA- 2023/06/19 13:08
CRDT- 2023/05/21 18:05
PHST- 2022/12/21 00:00 [received]
PHST- 2023/04/26 00:00 [revised]
PHST- 2023/05/15 00:00 [accepted]
PHST- 2023/06/19 13:08 [medline]
PHST- 2023/05/22 00:41 [pubmed]
PHST- 2023/05/21 18:05 [entrez]
AID - S1438-4639(23)00080-9 [pii]
AID - 10.1016/j.ijheh.2023.114189 [doi]
PST - ppublish
SO  - Int J Hyg Environ Health. 2023 Jun;251:114189. doi: 10.1016/j.ijheh.2023.114189. 
      Epub 2023 May 19.