PMID- 37211295
OWN - NLM
STAT- MEDLINE
DCOM- 20230703
LR  - 20230703
IS  - 1873-1597 (Electronic)
IS  - 1572-1000 (Linking)
VI  - 42
DP  - 2023 Jun
TI  - Retinal vascular density change in patients with heart failure.
PG  - 103621
LID - S1572-1000(23)00348-4 [pii]
LID - 10.1016/j.pdpdt.2023.103621 [doi]
AB  - PURPOSE: The aim of this study is to assess choroid thickness, retinal vessel 
      density in the superficial capillary plexus layer and deep capillary plexus layer 
      in heart failure (HF) using optical coherence tomography angiography (OCT-A). 
      METHODS: 36 healthy participants (group 1), 33 patients with HF were assessed for 
      this study. HF patients had a left ventricular ejection fraction (LVEF) <50%. HF 
      patients were divided into 2 groups according to the New York Heart Association 
      (NYHA). 15 patients were evaluated as group 2 according to NYHA and 18 patients 
      as group 3 according to NYHA. Choroid thickness, superficial and deep capillary 
      plexus perfusion were analyzed between groups using OCT-A. RESULTS: Choroid 
      thicknesses were found to be significantly decrease in the HF groups. Superficial 
      capillary plexus density was compared with the control group, no statistically 
      significant difference was found between the HF groups. But among the HF groups, 
      a statistically significant decrease was found in group 3 patients. Deep 
      capillary plexus density was compared with the control group, a statistically 
      significant decrease was found in group 3. In addition, deep capillary plexus 
      density a statistically significant difference was found between the groups HF. 
      CONCLUSIONS: Patients with HF showed decreased flow density compared with healthy 
      controls. In addition, significant changes were found in flow densities among the 
      HF groups. Retinal perfusion measured using OCT-A may give an idea about the 
      hemodynamic status and microperfusion of HF patients.
CI  - Copyright (c) 2023 Elsevier B.V. All rights reserved.
FAU - Topaloglu, Caner
AU  - Topaloglu C
AD  - Department of Cardiology, Izmir University of Economics, Izmir, Turkey. 
      Electronic address: topalolu@gmail.com.
FAU - Bekmez, Sinan
AU  - Bekmez S
AD  - Department of Ophthalmology, University of Health Sciences Dr. Behcet Uz Child 
      Disease and Pediatric Surgery Training and Research Hospital, Izmir, Turkey.
LA  - eng
PT  - Journal Article
DEP - 20230519
PL  - Netherlands
TA  - Photodiagnosis Photodyn Ther
JT  - Photodiagnosis and photodynamic therapy
JID - 101226123
RN  - 0 (Photosensitizing Agents)
SB  - IM
MH  - Humans
MH  - Microvascular Density
MH  - Stroke Volume
MH  - Fluorescein Angiography/methods
MH  - Ventricular Function, Left
MH  - *Photochemotherapy/methods
MH  - Photosensitizing Agents
MH  - Tomography, Optical Coherence/methods
MH  - *Heart Failure/diagnostic imaging
OTO - NOTNLM
OT  - Heart failure
OT  - Microvascular changes
OT  - Optical coherence tomography angiography
COIS- Declaration of Competing Interest The following authors have no financial 
      disclosures: CT, SB.
EDAT- 2023/05/22 00:41
MHDA- 2023/07/03 06:41
CRDT- 2023/05/21 19:27
PHST- 2023/01/30 00:00 [received]
PHST- 2023/05/12 00:00 [revised]
PHST- 2023/05/16 00:00 [accepted]
PHST- 2023/07/03 06:41 [medline]
PHST- 2023/05/22 00:41 [pubmed]
PHST- 2023/05/21 19:27 [entrez]
AID - S1572-1000(23)00348-4 [pii]
AID - 10.1016/j.pdpdt.2023.103621 [doi]
PST - ppublish
SO  - Photodiagnosis Photodyn Ther. 2023 Jun;42:103621. doi: 
      10.1016/j.pdpdt.2023.103621. Epub 2023 May 19.