PMID- 37211499
OWN - NLM
STAT- MEDLINE
DCOM- 20230905
LR  - 20230905
IS  - 1545-7214 (Electronic)
IS  - 1064-7481 (Linking)
VI  - 31
IP  - 10
DP  - 2023 Oct
TI  - Lipopolysaccharide, Immune Biomarkers and Cerebral Amyloid-Beta Deposition in 
      Older Adults With Mild Cognitive Impairment & Major Depressive Disorder.
PG  - 786-795
LID - S1064-7481(23)00288-9 [pii]
LID - 10.1016/j.jagp.2023.04.014 [doi]
AB  - OBJECTIVE: Inflammatory activation and increased immune response to 
      lipopolysaccharide occur in both depression and cognitive decline and may link 
      these two conditions. We investigated whether lipopolysaccharide (LPS), LPS 
      binding protein (LBP) and peripheral biomarkers of immune response were 
      associated with increased cerebral deposition of amyloid-beta (Abeta) in older 
      adults with mild cognitive impairment (MCI) and remitted major depressive 
      disorder (rMDD). DESIGN: Cross-sectional analysis. SETTING: Five academic health 
      centers in Toronto. PARTICIPANTS: Older adults with MCI with/without rMDD. 
      MEASUREMENTS: We investigated the associations among serum LPS, LBP, biomarkers 
      of inflammatory activation - Interleukin-6 (IL-6), C-reactive protein (CRP), 
      monocyte chemoattractant protein-1 (MCP-1), and cerebral Abeta deposition 
      quantified by positron emission tomography. RESULTS: Among 133 study participants 
      (82 with MCI and 51 with MCI+rMDD) there was no association between LPS (beta - 
      0.17, p = 0.8) or LBP (beta - 0.11, p = 0.12) and global deposition of Abeta 
      following adjustment for age, gender, and APOE genotype in multivariable 
      regression analyses. LBP was positively correlated with CRP (r = 0.5, p <0.001) 
      and IL-6 (r = 0.2, p = 0.02) but no inflammatory biomarker was associated with 
      Abeta deposition; rMDD was not associated with deposition of Abeta (beta -0.09, 
      p = 0.22). CONCLUSION: In this cross-sectional analysis, we did not find an 
      association among LPS/LBP, immune biomarkers or rMDD and global deposition of 
      Abeta. Future analyses should assess the longitudinal relationships between 
      peripheral and central biomarkers of immune activation, depression and cerebral 
      Abeta deposition.
CI  - Copyright (c) 2023 American Association for Geriatric Psychiatry. Published by 
      Elsevier Inc. All rights reserved.
FAU - Feng, Vivian
AU  - Feng V
AD  - Neuropsychopharmacology Research Group (VF, KL, NH, AK, ST, DG), Sunnybrook 
      Research Institute, Toronto, Canada.
FAU - Lanctot, Krista
AU  - Lanctot K
AD  - Neuropsychopharmacology Research Group (VF, KL, NH, AK, ST, DG), Sunnybrook 
      Research Institute, Toronto, Canada; Department of Psychiatry (KL, NH, CEF, AJF, 
      LM, BHM, BGP, TKR, NPV, AG-G, DG), Temerty Faculty of Medicine, University of 
      Toronto, Toronto, Canada.
FAU - Herrmann, Nathan
AU  - Herrmann N
AD  - Neuropsychopharmacology Research Group (VF, KL, NH, AK, ST, DG), Sunnybrook 
      Research Institute, Toronto, Canada; Department of Psychiatry (KL, NH, CEF, AJF, 
      LM, BHM, BGP, TKR, NPV, AG-G, DG), Temerty Faculty of Medicine, University of 
      Toronto, Toronto, Canada.
FAU - Kiss, Alex
AU  - Kiss A
AD  - Neuropsychopharmacology Research Group (VF, KL, NH, AK, ST, DG), Sunnybrook 
      Research Institute, Toronto, Canada; Department of Health Policy, Management and 
      Evaluation (AK), University of Toronto, Toronto, Canada.
FAU - Fischer, Corinne E
AU  - Fischer CE
AD  - Department of Psychiatry (KL, NH, CEF, AJF, LM, BHM, BGP, TKR, NPV, AG-G, DG), 
      Temerty Faculty of Medicine, University of Toronto, Toronto, Canada; Keenan 
      Research Centre for Biomedical Science (CEF), St. Michael's Hospital, Toronto, 
      Canada.
FAU - Flint, Alastair J
AU  - Flint AJ
AD  - Department of Psychiatry (KL, NH, CEF, AJF, LM, BHM, BGP, TKR, NPV, AG-G, DG), 
      Temerty Faculty of Medicine, University of Toronto, Toronto, Canada; Centre for 
      Mental Health (AJF), University Health Network and University of Toronto, 
      Toronto, Canada.
FAU - Mah, Linda
AU  - Mah L
AD  - Department of Psychiatry (KL, NH, CEF, AJF, LM, BHM, BGP, TKR, NPV, AG-G, DG), 
      Temerty Faculty of Medicine, University of Toronto, Toronto, Canada; Department 
      of Psychiatry (LM, NPV), Baycrest Health Sciences Centre, Toronto, Canada; Rotman 
      Research Institute (LM), Baycrest Health Sciences Centre, Toronto, Canada.
FAU - Mulsant, Benoit H
AU  - Mulsant BH
AD  - Department of Psychiatry (KL, NH, CEF, AJF, LM, BHM, BGP, TKR, NPV, AG-G, DG), 
      Temerty Faculty of Medicine, University of Toronto, Toronto, Canada; Adult 
      Neurodevelopment and Geriatric Psychiatry Division (BHM, BGP, TKR, AG-G), Centre 
      for Addiction and Mental Health, Toronto, Canada; Toronto Dementia Research 
      Alliance (BMH, BGP, TKR, NPV), University of Toronto, Toronto, Canada.
FAU - Pollock, Bruce G
AU  - Pollock BG
AD  - Department of Psychiatry (KL, NH, CEF, AJF, LM, BHM, BGP, TKR, NPV, AG-G, DG), 
      Temerty Faculty of Medicine, University of Toronto, Toronto, Canada; Adult 
      Neurodevelopment and Geriatric Psychiatry Division (BHM, BGP, TKR, AG-G), Centre 
      for Addiction and Mental Health, Toronto, Canada; Toronto Dementia Research 
      Alliance (BMH, BGP, TKR, NPV), University of Toronto, Toronto, Canada.
FAU - Rajji, Tarek K
AU  - Rajji TK
AD  - Department of Psychiatry (KL, NH, CEF, AJF, LM, BHM, BGP, TKR, NPV, AG-G, DG), 
      Temerty Faculty of Medicine, University of Toronto, Toronto, Canada; Adult 
      Neurodevelopment and Geriatric Psychiatry Division (BHM, BGP, TKR, AG-G), Centre 
      for Addiction and Mental Health, Toronto, Canada; Toronto Dementia Research 
      Alliance (BMH, BGP, TKR, NPV), University of Toronto, Toronto, Canada.
FAU - Tumati, Shankar
AU  - Tumati S
AD  - Neuropsychopharmacology Research Group (VF, KL, NH, AK, ST, DG), Sunnybrook 
      Research Institute, Toronto, Canada.
FAU - Verhoeff, Nicolaas Paul
AU  - Verhoeff NP
AD  - Department of Psychiatry (KL, NH, CEF, AJF, LM, BHM, BGP, TKR, NPV, AG-G, DG), 
      Temerty Faculty of Medicine, University of Toronto, Toronto, Canada; Department 
      of Psychiatry (LM, NPV), Baycrest Health Sciences Centre, Toronto, Canada; 
      Toronto Dementia Research Alliance (BMH, BGP, TKR, NPV), University of Toronto, 
      Toronto, Canada.
FAU - Graff-Guerrero, Ariel
AU  - Graff-Guerrero A
AD  - Department of Psychiatry (KL, NH, CEF, AJF, LM, BHM, BGP, TKR, NPV, AG-G, DG), 
      Temerty Faculty of Medicine, University of Toronto, Toronto, Canada; Adult 
      Neurodevelopment and Geriatric Psychiatry Division (BHM, BGP, TKR, AG-G), Centre 
      for Addiction and Mental Health, Toronto, Canada.
FAU - Gallagher, Damien
AU  - Gallagher D
AD  - Neuropsychopharmacology Research Group (VF, KL, NH, AK, ST, DG), Sunnybrook 
      Research Institute, Toronto, Canada; Department of Psychiatry (KL, NH, CEF, AJF, 
      LM, BHM, BGP, TKR, NPV, AG-G, DG), Temerty Faculty of Medicine, University of 
      Toronto, Toronto, Canada. Electronic address: Damien.gallagher@sunnybrook.ca.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20230429
PL  - England
TA  - Am J Geriatr Psychiatry
JT  - The American journal of geriatric psychiatry : official journal of the American 
      Association for Geriatric Psychiatry
JID - 9309609
RN  - 0 (Lipopolysaccharides)
RN  - 0 (Interleukin-6)
RN  - 0 (Amyloid beta-Peptides)
RN  - 0 (Biomarkers)
SB  - IM
MH  - Humans
MH  - Aged
MH  - *Depressive Disorder, Major/complications
MH  - Lipopolysaccharides
MH  - *Alzheimer Disease/psychology
MH  - Cross-Sectional Studies
MH  - Interleukin-6
MH  - Amyloid beta-Peptides/metabolism
MH  - *Cognitive Dysfunction/complications
MH  - Positron-Emission Tomography
MH  - Biomarkers
OTO - NOTNLM
OT  - Lipopolysaccharide
OT  - amyloid-beta
OT  - major depressive disorder
EDAT- 2023/05/22 00:41
MHDA- 2023/09/05 06:42
CRDT- 2023/05/21 21:59
PHST- 2023/02/10 00:00 [received]
PHST- 2023/04/21 00:00 [revised]
PHST- 2023/04/24 00:00 [accepted]
PHST- 2023/09/05 06:42 [medline]
PHST- 2023/05/22 00:41 [pubmed]
PHST- 2023/05/21 21:59 [entrez]
AID - S1064-7481(23)00288-9 [pii]
AID - 10.1016/j.jagp.2023.04.014 [doi]
PST - ppublish
SO  - Am J Geriatr Psychiatry. 2023 Oct;31(10):786-795. doi: 
      10.1016/j.jagp.2023.04.014. Epub 2023 Apr 29.