PMID- 37212092
OWN - NLM
STAT- MEDLINE
DCOM- 20230620
LR  - 20230620
IS  - 1875-8908 (Electronic)
IS  - 1387-2877 (Linking)
VI  - 93
IP  - 4
DP  - 2023
TI  - Association of Type 2 Diabetes Mellitus with Cognitive Function in Adults: A 
      Prospective Cohort Study.
PG  - 1509-1520
LID - 10.3233/JAD-220822 [doi]
AB  - BACKGROUND: The Cognitive role of untreated type 2 diabetes mellitus (T2DM) has 
      been less well substantiated. OBJECTIVE: We sought to explore the prospective 
      association of T2DM and untreated T2DM with cognitive function among middle-aged 
      and older Chinese adults. METHODS: Data of 7,230 participants without baseline 
      brain damage/mental retardation, or memory-related diseases in China Health and 
      Retirement Longitudinal Study (CHARLS) from 2011- 2012 to 2015, were analyzed. 
      Fasting plasma glucose and self-reported information on T2DM diagnosis and 
      treatment were assessed. Participants were categorized into normoglycemia, 
      impaired fasting glucose (IFG), and T2DM (including untreated and treated T2DM) 
      groups. Episodic memory and executive function were assessed by modified 
      Telephone Interview for Cognitive Status every two years. We used generalized 
      estimating equation model to examine the association of baseline T2DM status with 
      cognitive function in succeedingyears. RESULTS: Compared to those with 
      normoglycemia, T2DM was associated with worse overall cognitive function after 
      controlling for demographic variables, lifestyles, follow-up time, major clinical 
      factors, and baseline cognitive function, although the associations were 
      statistically non-significant (beta= -0.19, 95% CI: -0.39, 0.00). However, a 
      significant association was mainly observed for those with untreated T2DM 
      (beta= -0.26, 95% CI: -0.47, -0.04), especially in the domain of executive function 
      (beta= -0.19, 95% CI: -0.35, -0.03). In general, IFG and treated T2DM individuals 
      had similar levels of cognitive function with normoglycemia participants. 
      CONCLUSION: Our findings supported a detrimental role of untreated T2DM on 
      cognitive function among middle-aged and older adults. Screening and early 
      treatment for T2DM are warranted for maintaining better cognitive function in 
      later life.
FAU - Chen, Xiao
AU  - Chen X
AD  - School of Public Health, the Second Affiliated Hospital, Zhejiang University 
      School of Medicine, Hangzhou, Zhejiang, China.
FAU - Li, Wanlu
AU  - Li W
AD  - School of Public Health, the Second Affiliated Hospital, Zhejiang University 
      School of Medicine, Hangzhou, Zhejiang, China.
FAU - Huang, Yuhui
AU  - Huang Y
AD  - School of Public Health, the Second Affiliated Hospital, Zhejiang University 
      School of Medicine, Hangzhou, Zhejiang, China.
FAU - Yang, Jiaxi
AU  - Yang J
AD  - Bia-Echo Asia Centre for Reproductive Longevity & Equality (ACRLE), Yong Loo Lin 
      School of Medicine, National University of Singapore, Singapore.
AD  - Department of Obstetrics and Gynaecology, Yong Loo Lin School of Medicine, 
      National University of Singapore, Singapore.
FAU - Tao, Yang
AU  - Tao Y
AD  - School of Public Health, the Second Affiliated Hospital, Zhejiang University 
      School of Medicine, Hangzhou, Zhejiang, China.
FAU - Huang, Liyan
AU  - Huang L
AD  - School of Public Health, the Second Affiliated Hospital, Zhejiang University 
      School of Medicine, Hangzhou, Zhejiang, China.
FAU - Shen, Jiadong
AU  - Shen J
AD  - School of Public Health, the Second Affiliated Hospital, Zhejiang University 
      School of Medicine, Hangzhou, Zhejiang, China.
FAU - Ma, Yanan
AU  - Ma Y
AD  - Department of Biostatistics and Epidemiology, School of Public Health, China 
      Medical University, Shenyang, Liaoning, China.
FAU - Liu, Zuyun
AU  - Liu Z
AD  - School of Public Health, the Second Affiliated Hospital, Zhejiang University 
      School of Medicine, Hangzhou, Zhejiang, China.
FAU - Xu, Xin
AU  - Xu X
AD  - School of Public Health, the Second Affiliated Hospital, Zhejiang University 
      School of Medicine, Hangzhou, Zhejiang, China.
FAU - Xu, Xiaolin
AU  - Xu X
AD  - School of Public Health, the Second Affiliated Hospital, Zhejiang University 
      School of Medicine, Hangzhou, Zhejiang, China.
FAU - Zong, Geng
AU  - Zong G
AD  - CAS Key Laboratory of Nutrition, Metabolism and Food Safety, Shanghai Institute 
      of Nutrition and Health, University of Chinese Academy of Sciences, Chinese 
      Academy of Sciences, Shanghai, China.
FAU - Yuan, Changzheng
AU  - Yuan C
AD  - School of Public Health, the Second Affiliated Hospital, Zhejiang University 
      School of Medicine, Hangzhou, Zhejiang, China.
AD  - Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA, 
      USA.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Netherlands
TA  - J Alzheimers Dis
JT  - Journal of Alzheimer's disease : JAD
JID - 9814863
SB  - IM
MH  - Humans
MH  - Middle Aged
MH  - Aged
MH  - *Diabetes Mellitus, Type 2/complications/epidemiology
MH  - Longitudinal Studies
MH  - Prospective Studies
MH  - *Prediabetic State
MH  - Cognition
OTO - NOTNLM
OT  - Alzheimer's disease
OT  - cognitive function
OT  - prospective study
OT  - type 2 diabetes mellitus
OT  - untreated T2DM
EDAT- 2023/05/22 06:42
MHDA- 2023/06/20 06:42
CRDT- 2023/05/22 04:43
PHST- 2023/06/20 06:42 [medline]
PHST- 2023/05/22 06:42 [pubmed]
PHST- 2023/05/22 04:43 [entrez]
AID - JAD220822 [pii]
AID - 10.3233/JAD-220822 [doi]
PST - ppublish
SO  - J Alzheimers Dis. 2023;93(4):1509-1520. doi: 10.3233/JAD-220822.