PMID- 37214173
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20231208
IS  - 1939-4551 (Print)
IS  - 1939-4551 (Electronic)
IS  - 1939-4551 (Linking)
VI  - 16
IP  - 5
DP  - 2023 May
TI  - Multi-omics profiling approach in food allergy.
PG  - 100777
LID - 10.1016/j.waojou.2023.100777 [doi]
LID - 100777
AB  - The prevalence of food allergy (FA) among children is increasing, affecting 
      nearly 8% of children, and FA is the most common cause of anaphylaxis and 
      anaphylaxis-related emergency department visits in children. Importantly, FA is a 
      complex, multi-system, multifactorial disease mediated by food-specific 
      immunoglobulin E (IgE) and type 2 immune responses and involving environmental 
      and genetic factors and gene-environment interactions. Early exposure to external 
      and internal environmental factors largely influences the development of immune 
      responses to allergens. Genetic factors and gene-environment interactions have 
      established roles in the FA pathophysiology. To improve diagnosis and 
      identification of FA therapeutic targets, high-throughput omics approaches have 
      emerged and been applied over the past decades to screen for potential FA 
      biomarkers, such as genes, transcripts, proteins, and metabolites. In this 
      article, we provide an overview of the current status of FA omics studies, namely 
      genomic, transcriptomic, epigenomic, proteomic, exposomic, and metabolomic. The 
      current development of multi-omics integration of FA studies is also briefly 
      discussed. As individual omics technologies only provide limited information on 
      the multi-system biological processes of FA, integration of population-based 
      multi-omics data and clinical data may lead to robust biomarker discovery that 
      could translate into advances in disease management and clinical care and 
      ultimately lead to precision medicine approaches.
CI  - (c) 2023 The Authors.
FAU - Devonshire, Ashley
AU  - Devonshire A
AD  - Division of Allergy and Immunology, Cincinnati Children's Hospital Medical 
      Center, Department of Pediatrics, University of Cincinnati College of Medicine, 
      Cincinnati, OH, USA.
FAU - Gautam, Yadu
AU  - Gautam Y
AD  - Division of Asthma Research, Cincinnati Children's Hospital Medical Center, 
      Department of Pediatrics, University of Cincinnati College of Medicine, 
      Cincinnati, OH, USA.
FAU - Johansson, Elisabet
AU  - Johansson E
AD  - Division of Asthma Research, Cincinnati Children's Hospital Medical Center, 
      Department of Pediatrics, University of Cincinnati College of Medicine, 
      Cincinnati, OH, USA.
FAU - Mersha, Tesfaye B
AU  - Mersha TB
AD  - Division of Asthma Research, Cincinnati Children's Hospital Medical Center, 
      Department of Pediatrics, University of Cincinnati College of Medicine, 
      Cincinnati, OH, USA.
LA  - eng
GR  - KL2 TR001426/TR/NCATS NIH HHS/United States
PT  - Journal Article
PT  - Review
DEP - 20230515
PL  - United States
TA  - World Allergy Organ J
JT  - The World Allergy Organization journal
JID - 101481283
PMC - PMC10199264
OTO - NOTNLM
OT  - Food allergy
OT  - Genomics
OT  - Immunoglobulin E
OT  - Multi-omics
OT  - Oral food challenge
OT  - Skin prick test
EDAT- 2023/05/22 19:11
MHDA- 2023/05/22 19:12
PMCR- 2023/05/15
CRDT- 2023/05/22 12:07
PHST- 2022/11/30 00:00 [received]
PHST- 2023/04/05 00:00 [revised]
PHST- 2023/04/05 00:00 [accepted]
PHST- 2023/05/22 19:12 [medline]
PHST- 2023/05/22 19:11 [pubmed]
PHST- 2023/05/22 12:07 [entrez]
PHST- 2023/05/15 00:00 [pmc-release]
AID - S1939-4551(23)00037-6 [pii]
AID - 100777 [pii]
AID - 10.1016/j.waojou.2023.100777 [doi]
PST - epublish
SO  - World Allergy Organ J. 2023 May 15;16(5):100777. doi: 
      10.1016/j.waojou.2023.100777. eCollection 2023 May.